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Showing 4 results for Nourazar
Mohammad Reza Nasirzadeh , Alireza Nourazar, Mir Hadi Khayat Nouri, Leila Roshangar,
Volume 12, Issue 1 (spring 2012)
Abstract
Background & Objectives: Following to estrogen depletion in postmenopausal womens, its cardioprotective effect decreases. Stroke usually occurs in women during the menopause years. Estrogen hormone therapy is still controversial. Epidemiological data suggest that phytoestrogens have a preventive effect on various estrogen-related diseases/symptoms such as menopausal symptoms, cardiovascular diseases. Some studies suggest that genistein as an important component of soy have cardioprotection effects but its role on inflammation and cardiomyocte injury remained to be elucidated. So, this study was goaled to investigate the cardioprotective effect of methanolic soy extract on heart tissue injures. Method: In this study 40 female rats were randomly allocated into 4 groups: 1) Control (intact animals), 2) sham surgery (without ovarictomy), 3) ovariectomized (ovx), and 4) treatment (ovx and soy gavage) group that received 60mg/kg per day soy extract in drinking water for 28days (4 weeks). At the end of experiments, the rat heart tissue was processed histologically and the sections were stained with hematoxylin and eosin to examine under light microscope. Statistical analysis was performed using the wilcoxon test. Results: The results showed that ovariectomy significantly increased inflammation and cardiomyocte injury and soy extract significantly promoted heart tissue recovery (p<0.05). Conclosions: This study indicated that oral administration of soy extract has a positive effect on attenuation of inflammation and myocyte injury in ovariectomized rat.
Mohammad Reza Nasirzadeh , Mohammad Heykalabadi , Alireza Nourazar ,
Volume 14, Issue 2 (summer 2014)
Abstract
Background & Objectives: Diabetes is a chronic disease characterized by derangement in protein, fat and carbohydrate metabolism. Most of hypoglycemic agent used in medicine for diabetes treatment are reported to have side effects for long run. On the other hand, increase in oxidative stress is effective in the genesis of diabetes. Therefore, the purpose of this study was to assess the effect of alcoholic extract of Euphorbia cyparissias on serum glucose and antioxidant enzymes level in diabetic male rats. Methods : In this study, 40 adult male Wistar rats weighting 250±20 grams divided into four groups randomly: control, diabetic animals, treatment 1 and treatment 2 which received 500 and 250 mg/kg of E.cyparissias extract for 21 days by gastric gavage, respectively. At the end of the treatment, level of antioxidant enzymes including TAC, MDA, SOD and GPX and also blood glucose were determined in animal's serum. Results : The blood glucose levels were significantly lowered in the group of treatment 1 compared to diabetic group (p<0.05). Results showed that MDA level of serum was increased significantly in diabetic group in comparison with control group (p<0.05). Furthermore, the TAC, SOD and GPX level were increased significantly in the group of treatment 1 compared to diabetic group (p<0.05). Conclusion : This study showed that oral administration of E.cyparissias extract has antidiabetic and antioxidant activity in streptozotocin induced diabetic rats.
Behrouz Shademan, Amir Ajoolabady, Alireza Nourazarian,
Volume 21, Issue 3 (Autumn 2021)
Abstract
Background & objectives: Stroke is one of the most common causes of death worldwide and has distinctive features. Moreover, the different types of strokes are characterized by different physiopathological mechanisms. In the present study, we aimed to investigate the serum levels of ATG5 and apo B-48 and their diagnostic value in patients with ischemic stroke.
Methods: We selected 100 participants, including 50 ischemic stroke patients (22 women and 28 men) as the case group and 50 healthy individuals (23 women and 27 men) as the control group. Then, we conducted a case-control study in Imam Reza Hospital (Tabriz, Iran) from March 2016 to April 2016. Serum levels of ATG 5 and Apo B-48 were measured in both groups. We also evaluated the additional diagnostic value of these factors in both groups using receptor-related power analysis (ROC).
Results: The mean serum levels of ATG 5 and apo B-48 were significantly higher in the case group than in the control group (p<0.0001). The values under the ROC curve (AUC) for ATG5 and apo B-48 were 0.96 and 0.91, respectively. The area under the ROC curve indicates that ATG 5 and apo B 48 are appropriate biomarkers for diagnosing ischemic stroke.
Conclusion: Serum levels of ATG 5 and apo B -48 are significantly higher in patients with ischemic stroke than in healthy individuals and may be considered diagnostic biomarkers in patients with ischemic stroke.
Behrouz Shademan, Masoud Nikanfar, Jafar Rezaei, Mehdi Hassanpour, Mohammad Nouri, Alireza Nourazarian,
Volume 22, Issue 2 (Summer 2022)
Abstract
Background & objectives: Evidence suggests that microRNAs (miRNAs) are essential for immune cell differentiation and function. In addition, miRNAs play an essential role in regulating the expression of pro-inflammatory genes in neurons. Therefore, we investigated the relationship between miRNA expression and inflammatory markers in the CSF of patients with multiple sclerosis.
Methods: RT-PCR analysis was performed on CSF samples from patients with multiple sclerosis (MS) and a control group to measure the expression level of miRNA-21, miRNA-155, miRNA-182, and miRNA-437. In addition, the levels of the inflammatory cytokines including IL-1β, IL-6, and TNF-α in CSF were measured using ELISA. A quantitative turbidimetric method was also used to measure high-sensitivity C-reactive protein (hs-CRP).
Results: A significant difference was found in the expression level of miRNAs and inflammatory factors in the CSF of patients with MS compared with the control group (p<0.05). The results of receiver operating characteristic (ROC) analysis showed the area under the curve for miRNA-21 (AUC=0.97, p<0.0001), miRNA-182 (AUC=0.97, p<0.0001), and miRNA-155 (AUC=0.96, p<0.0001). The miRNA-155 level in CSF played a very important role in the accurate diagnosis of MS. Significant correlations were found between inflammatory cytokines and miRNA-21, miRNA-155, and miRNA-182, as well as an indirect and moderate correlation between miRNA-437 and hs-CRP.
Conclusion: In MS patients, CSF levels of IL-1, IL-6, TNF-α, hs-CRP, and selected miRNAs can be used as biomarkers of CNS inflammation and neurodegenerative processes.
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