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Showing 3 results for Noroozi
Khatere Seylani, Masoome Aghamohammadi, Khlil Rostami, Vadood Noroozi,
Volume 5, Issue 3 (Autumn 2005)
Abstract
Background & Objective: Postoperative nausea and vomiting is the most common complication of anesthesia with an approximate prevalence of 30% up to 70% (in high risk patients). In recent years several articles have investigated the effects of antiemetic and anesthetic drugs on postoperative nausea and vomiting, but the nonpharmacological methods, which are cost-effective and have no side effects, are rare. Since it is essential for patients to be on fast before surgeries which require general anesthesia, occurrence of dehydration and extra cellular fluid volume deficit and subsequently nausea and vomiting are expected and anticipated. Thus in this study the effect of preoperative intravenous fluid on postoperative nausea and vomiting was explored. Methods: This clinical trial study was performed in two experimental and control groups, with 30 subjects in each. Experimental group were given a 1- liter bolus of intravenous normal saline preoperatively in addition to routine IV fluid. Finally the incidence of postoperative nausea and vomiting was observed and compared between two groups. Results : According to statistical tests, the differences between age, preoperative and postoperative NPO duration, use of antiemetics and the duration of hospitalization in two groups were statistically significant but the differences between other demographic variables and the volume of intraoperative intravenous fluid received during the surgery were not. Results showed that experimental group had significantly lower incidence of nausea and vomiting (20% and 10% respectively) in comparison with control group (50%). According to chi-square test, the rate of postoperative nausea and vomiting was significantly different in two groups. (p=0.015 and p=0.001 respectively) Also, preoperative NPO duration had significant relationship with postoperative vomiting (p= 0.05). Conclusion: Regarding the positive effect of intravenous fluid therapy on postoperative nausea and vomiting as a cost effective and harmless method in surgery, its use is recommended.
Masoud Noroozianavval , Peghah Veisi, Mohammad Aghaeishahsavari , Hasan Argani, Nadere Rashtchizadeh, Amir Ghorbanihaghjo,
Volume 7, Issue 3 (Autumn 2007)
Abstract
Background & Objectives : Panel-reactive antibody (PRA) is a routine test to evaluate for sensitized human leukocyte antigens (HLA) before kidney transplantation. The present study evaluates the correlation of renin-angiotensin system (RAS) polymorphisms with the level of PRA in renal transplant candidates. Methods: This study included 108 renal transplant candidates. The current patients sera were screened by standard complement-dependent microlymphocytotoxicity technique. RAS polymorphisms were determined by polymerase chain reaction. PRA<10, 10-29, 30-49, and ≥50 considered as negative, mild, moderate, and highly positive PRA, respectively. Results: Twelve (11.1%) patients had positive PRA, among them 10 (83.3%) had mild and 2 (16.7%) of them had moderate PRA levels we had no highly positive PRA. Ninety-six of cases (88.9%) were negative for PRA. There was no significant correlation between discrete RAS polymorphisms (alone or together) and the degree of panel antibody reactivity (P>0.05). Conclusion: We suggest that none of the RAS polymorphisms could predict the positivity degree of PRA level.
Mohammad Aghaeishahsavari , Masoud Noroozianavval, Peghah Veisi , Hasan Argani , Nadereh Rashtchizadeh , Amir Ghorbanihaghjo, Sima Abedi-Azar, Amirmansoor Vatankah,
Volume 8, Issue 2 (Summer 2008)
Abstract
Background & Objective: As renin-angiotensin system (RAS) activity could affect the severity of oxidative stress and inflammatory markers the effect of enalapril and losartan on these markers in renal transplant recipients (RTRs) with RAS polymorphisms was assessed. Methods: After determination of RAS genotypes including angiotensin converting enzyme (ACE I/D), Angiotensinogen (AGT M235T) and angiotensin II type 1 receptor (ATR1 A1166C) by PCR, seventy-six RTRs recruited to four groups randomly: first group (17 patients) and second group (24 patients) were treated with E (E+: 10mg/daily) and L (L+: 50 mg/daily) alone, respectively. The third group (17 patients as positive control) received E+L (E+L+: 10mg/daily + 50 mg/daily) and the 4th group (18 patients as negative control) received no medication (E-L-). Hs-CRP and total anti-oxidant (TA) as inflammatory and anti-oxidative markers were measured after 2 months. After 2 weeks as washout period, E group changed to L and vice versa as a cross-over design. They were followed for another 8 weeks and hs-CRP and TA were retested. Results: Following up the patients (after 2, 4 months of treatment) in treated groups revealed that hs-CRP and TA levels were significantly decreased and increased (consequently) in E+L+, L+, E+ groups (P<0.05). On analyzing the relationship between RAS polymorphisms with baseline hs-CRP and TA levels, CC genotype of ATR1 had lower hs-CRP levels (P=0.04). But none of the RAS polymorphisms could predict the anti-oxidative and anti-inflammatory response rate to the drugs (P>0.05). Conclusion: E and/or L reduce hs-CRP and increase TA regardless of the RAS genotypes.
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