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  Background & Objectives: Low dose aspirin has been widely used in the prevention and treatment of cardiovascular disease. The bimodel action of aspirin on serum uric acid showed that aspirin at a high dosage promoted uricusuria while intermediate doses were (1-2gr/day) caused uric acid retention. The main goal of this study was to survey the effect of low dose aspirin on serum level of uric acid in patients with ischemic heart disease.

  Methods: The study design was cross-sectional and analytical type. In this study we selected 60 patients who used low dose aspirin among the patients of Imam Khomeini hospital's heart clinic (2008-9) and their information was registered in special questionnaires including serum level of uric acid and creatinine before and after prescription of aspirin. Data was then statistically analyzed using Paired t test and Willcoxon.

  Results: Of 60 patients 11 ( 18.3 % ) were under 50 years and 49 ( 81.7%) were above 50 years. The male to female ratio was 1.72 (38: 63.3% versus 22: 36.7%). 53.3 % of patients showed an increase in serum uric acid, but 46.7% did not. No significant differences in uric acid levels was found in patients under 50 years before and after administration of aspirin. Serum uric acid levels were increased after administration of 0.1unit of aspirin.

  Conclusion: Low -dose aspirin (80 mg/ day) caused a slight but significant increase in serum uric acid and creatinine levels in patients over 50 years of age.

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  Background & Objectives: Hypertension is one of the most important and common health problems in societies. Hypertension is often asymptomatic and can be simply treated. Many of drugs are available for treatment of hypertension i ncluding d iuretics, beta blockers, blockers of calcium channel, angiotensin-converting enzyme inhibitors, angiotensin receptor antagonists, alpha blockers and arterial dilators. This research was performed to evaluate the efficacy of some of these drugs on the hypertension. This may help to choose an appropriate medication for the treatment of stage 2 hypertension.

  Methods: A total of 150 patients with hypertension who were not under antihypertensive treatment and didn’t have contraindications for using hydrochlorothiazide , enalapril and atenolol were randomly allocated into three groups. These groups received atenolol 50 mg daily, hydrochlorothiazide 50 mg daily and enalapril 5 mg twice daily, respectively . After three weeks blood pressure of patients was measured and results were analyzed using SPSS.

  Results: Atenolol reduced systolic blood pressure (26.7±6.7 mm Hg 16.1%), diastolic blood pressure (10.3±1.2 mm Hg 10.4%) and mean arterial blood pressure (16.1±6.4 mm Hg 13.1%). Enalapril reduced systolic blood pressure (30.6±8.8 mm Hg 17.4%), diastolic blood pressure (11.5±4.4 mm Hg 11.4%) and mean arterial blood pressure (17.9±7.0 mm Hg 14.2%). Hydrochlorothiazide reduced systolic blood pressure (25.1±5.8 mm Hg 14.6%), diastolic blood pressure (9.2±2.3 mm Hg 9.3%) and mean arterial blood pressure (14.5±6.4 mm Hg 11.8%).

  Conclusion: Despite recommendations the use of hydrochlorothiazidein the treatment of hypertension, seems lower effect only use of this drug groups in comparison with other groups, and maybe add this category to other drugs and combined treatment is better than monotherapy with these groups .

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  Background & Objectives: Coronary bifurcation lesions are important, complex lesions with different therapeutic strategies. In this study, patients with Coronary bifurcation lesions were treated and clinical results in these patients were followed during the nine-month period.

  Methods: This descriptive analytical study was performed between January 2007 to December 2008 at Tabriz Shahid Madani Cardiovascular Center. We have studied 96 patients (83 male and 13 female). Patients on the basis of one or two stents were placed in one group and the other groups were divided based on the use of Drug Eluting Stent and Bare Metal Stent. After diagnostic angiography if coronary bifurcation lesions were present based on Medina classification, appropriate angioplasty treatment was carried out. In a situations including chest pain, electrocardiographic changes or the objective evidence of ischemia and indication of angiography, appropriate diagnostic tests during follow up period were done. Clinical outcomes including acute coronary events were recorded. And result analyzed using SPSS version 16 . Chi-square ، Fisher and T tests were used to compare the relationship between variables.

  Results: In this study 86.5% was male and 13.5% female. The mean age of these patients was 56±9.9 years old. The most prevalent risk factor was HTN with 41.7% incidence and 55.2% of patient had chronic stable angina and 26% of them had history of acute myocardial infarction, 7.2% with history of PCI and 5.2% with history Of CABGS. Most prevalent site of bifurcation was ALD/diagonal with 65.5% incidence. The most prevalent complication was mild bleeding from puncture site with 10.4% and 5.2% of patients had mild hematoma. Among patients with two stents versus one stent presence of AMI presentation with CSA, ST Elevation in ECG was statistically significant. Also involvement of SB (side branch) lesions lengths at SB, kissing ballooning after implantation of two stents were statistically significant. Among patients with DES versus BMS usage of stent in RCA, LAD, lesion lengths at PMB (proximal main branch), DMP (distal main branch) and SB, procedure time, radiation dose, fluoroscopy time were statistically significant. Among two groups MACE (major acute coronary event) in two stents patient between 1-3 month and total MACE at first 6 month were statistically significant

  Conclusion: The age of patients treated with CBL was low, also more usage of BMS and stenting of BFLs with two BMS had weak results in this study but surprisingly total results of BMS and DES did not have significant difference after 9 months follow up between two groups.

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Background & objectives: Parasitic infections are among important health problems all over the world especially in developing countries. Considering the epidemiological importance of parasitological diseases and necessity to evaluation the parasites prevalence in different areas and populations, current study aimed to determine the prevalence of intestinal parasites in patients admitted to the laboratories of Baqiyatallah Hospital in Tehran.

Methods: This is a retrospective cross sectional study in which stool examination reports of all referred patients (70978) to central and emergency laboratories of Baqiyatallah hospital were evaluated during 2010-2014. In this course, at least one stool sample of patients was assessed by direct smear and formalin-ethyl acetate methods. The data were analyzed using descriptive statistics in SPSS 16. Chi-square test was used for comparison of the prevalence.

Results: From 70978 patients, 42421(59.77%) and 28557(40.23%) were male and female, respectively. From 2617 infected individuals, 1841(70.3%) and 776 (29.7%) were males and females, respectively. The prevalence of pathogen and non-pathogen intestinal parasites was 2283(87.23%) and 334(12.76%) respectively. Also the prevalence of intestinal helminthes and protozoa in infected population was 0.42% and 99.57%, respectively. Blastocystis hominis and then Giardia lamblia were the prevalent parasites.

Conclusion: In current study the prevalence of parasites is lower than those reported in other investigations. Differences in geographical location, sample size, duration and type of study (prospective or retrospective) and study population may be effective agents. The higher prevalence of "Blastocystis hominis" in comparison with other parasites can attract more attention to improve the quality of laboratory and clinical diagnosis of this protozoa

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Background & objectives: Cardiac arrhythmia after CABG surgery is a common complication which results in other side effects. Therapeutic effect of prophylactic magnesium administration is controversial and there are many different ideas in this case. The aim of this study was to evaluate the therapeutic effects of magnesium in reducing cardiac arrhythmia after CABG.

Methods: The clinical trial enrolled 140 patients undergoing CABG. Based on the initial blood levels of magnesium, patients were divided into two groups, one group with low serum magnesium and the other group with normal one. The low serum magnesium group treated with magnesium preoperatively and had normal serum magnesium level before operation. Postoperatively, both groups were randomly divided into two sub-groups, one receiving 2 gr. of magnesium sulfate and the other group received placebo. Both groups monitored for occurrence of arrhythmia in the ICU – OH for 3 days. Data were analyzed with statistical methods. P value of <0.05 was considered statistically significant.

Results: The results showed that the occurrence of arrhythmia in any of the sub-groups was not significantly different from each other (p> 0.05). There was no significant relationship between blood levels of magnesium and arrhythmia at different days (p> 0.05).

Conclusions: Blood level of magnesium and prophylactic magnesium administration have not effect on reducing arrhythmia after CABG surgery. The highest incidence of arrhythmias happened in the hypomagnesium group without prophylaxis on the third day after surgery, but this difference was not statistically significant.

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Background & objectives: Diabetes mellitus is the sixth leading cause of death in individuals older than 25 years, and accounts for %18 of all deaths. The aim of this study was to investigate the TCD findings in diabetic patients with a history of less and more than 5 years.
Methods: In this descriptive, analytic study, all diabetic patients were divided into two groups based on the duration of diabetes, less and more than 5 years after diagnosis. TCD was performed on the patients, and maximum velocity and mean pulsatility index and resistivity index in the right and left Middle Cerebral Arteries (MCAs) and basilar artery were measured. The checklist was completed for all patients, and all data were analyzed by SPSS (v16) statistical software.
Results: Sixty four percent of the patients with duration less than 5 years (average age of 55.16 years) and 36 percent of those with duration more than 5 years (average age of 59.37 years) were men. There was no statistically significant difference between disease duration and Body Mass Index (BMI), but with an increase in duration of disease, HbA1C of patients was increased. There was no significant difference between the velocity of right, left and basilar arteries and diabetes duration. Also, there was a significant difference between diabetes duration and pulse index of right MCA and basilar. There was no significant difference between age, BMI and HbA1C and pulse and resistivity indexes among patients.
Conclusion: In this study abnormal pulse and resistance indexes in patients with duration more than 5 years was more than patients with less than 5, this may indicate the effect of diabetes duration on the vascular wall.