|
|
|
 |
Search published articles |
 |
|
Showing 19 results for Moghadam
Reza Ali Panah Moghadam , Mohamad Rahbani Nobar ,
Volume 6, Issue 2 (Summer 2006)
Abstract
Background & Objectives:Lipid peroxidation has recently attracted considerable attention. It has been linked to carcinogenesis, aging and variety of other diseases including atherosclerosis. Atherogenesis involves the complicated interaction between cells of the arterial wall and lipoproteins (mainly oxidized LDL). The aim of this study was to investigate the relationship between serum malodialdehyde (MDA), the important indicator of lipid peroxidation and alteration in serum lipids and lipoproteins concentrations in male patients with coronary artery disease (CAD). Methods: The subjects of this study were 51 male patients under 55 with angiographically comfirmed CAD admitted to Shahid Madani Hospital and 60 age and sex matched apparently healthy individuals as the control group. The serum level of MDA was measured by colorimetric method using thiobarbituric acid reaction and lipid and lipoproteins concentrations were determined by standard enzymatic methods. Results: Significant elevation in the level of MDA was noticed compared to the controls (P=0.03) . Serum concentrations of cholesterol, triglyceride, LDL-C and LDL - C /HDL - C ratio in cases were higher than those of the controls (P=0.03) . There was a positive and significant relationship between serum MDA and biochemical risk factors including Triglyceride, Cholesterol, LDL-C and LDL - C/HDL - C ratio (p=0.03). The correlation between serum MDA and serum HDL-C was negative and meaningful (P=0.03) . No relationship was observed between serum MDA with BMI and age in cases. Conclusion: Simultaneous control and monitoring of both dyslipoproteinemia and lipid peroxidation may be of equal importance in prevention of occurrence and progression of CAD.
Afshar Tamook , Fereidoon Ashenaie, Joobin Yeganeh Moghadam , Mahdi Chiniforush , Nayereh Amini Sani, Shahram Habibzadeh ,
Volume 7, Issue 1 (spring 2007)
Abstract
Background & Objective: Visceral leishmaniasis is a reticulo endothelia system and it is known as 'black fever' by Indians. According to WHO every year there are 500 thousand new cases of it in the world. The province of Ardabil, with 25-40% from all the country's leishmaniasis has a major part in the country and is considered as one of the main focuses in Iran. Due to its importance, this study was done to identify clinical signs and demographic characteristics of the patients. Methods: This was a descriptive cross-sectional study which was done retrospectively 110 children who were hospitalized in three different active hospitals between 1375-1382 entered in this study. Disease definition include parasite detection in bone marrow aspivation or special clinical signs (fever, spleenomegal, pansytopenia and weight loss) in addition direct agglutination test was positive. The samples were investigated in terms of demographic information. Place of living, clinical signs and the length of time between the symptoms of the disease and its diagnosis. To get to the results, simple descriptive statistics was used. 37.8% of the patients were diagnosed from the beginning of symptoms with in a month. Results: There were 56.4% boys and 43.6% girls of all the 110 children. DAT test was done in 97 patients which was positive in 91 cases (minimum positive titer 1/400). In 42 patients biopsy and bone marrow aspiration was done which was positive in 26 cases (lishman body detection). The age of the patients was 4 months -14 years. The most common findings were fever 97.3% and anorexia 97.1%. There was anemia in 90% thrombocytopenia in 60.8% and leukopenia in 24.8%. There was death in 6 patients (5.5%) and unresponsiveness to the treatment in 3 cases (2.7%). Conclusion: The results of the present study nearly corresponds to those of other studies. The main vulnerable community of visceral lieshmaniasis are mainly children. In order to decrease the mortality and morbidity its early diagnosis is essential. It is necessary that the physicians working in endemic regions be familiar enough with the disease.
Feizollah Akbari , Abbas Rahime, Hasan Eftekhar Ardabili, Negin Nahanmoghadam, Samira Shahbazzadegan,
Volume 9, Issue 3 (autumn 2009)
Abstract
Background & Objectives: Despite of high family planning coverage in Ardabil province comparing to other provinces of country, the population growth rate is higher than other provinces in Ardabil that presents incorrect, discontinuous, and interrupted use of intrauterine devices (IUD). This research was carried out to investigate the continuation, and factors affecting to interrupted use of IUD in women referring to health centers of Ardabil city in 2004. Methods: The Subjects of this descriptive-analytic and historical cohort study were 301 women. Data were collected by a questionnaire and were analyzed by Kaplan-Meier Survival and Log-Rank tests through SPSS software. Results: Duration of continuous use of IUD was more than 18 months among 77.1 % of subjects. Average duration was higher in 20-25 years women (24.5 ± 1 months). The lowest duration of continuous use of IUD was observed among women with age higher then 25 years old (14.3 ± 3.4 months). There was a significant relationship between discontinuous use of IUD and volume of menstrual bleeding (p=0.005). The mean of continuation in the women with a lot of bleeding was 20.5 ± 1 while for the women with low bleeding was 22.4 ± 1.5. Type of referring to IUD control had meaningful correlation (p=0.03) with average duration of using this device. Mean time of continuation in women that referred occasionally was 23.8 ± 0.6. There was significant relation between complication and IUD interruption. The highest interruption time belonged to the women that declared the infection, wound and PID (mean 25.5 months) and the lowest interruption time was observed in the women with bleeding and spotting (mean 18 months). Conclusion: Continuation of using IUD in 87.4 % of women was less than 6 months, in 81.4% was from 6 to 12 months, and in 72.1 % was from 12 to18 months. The most common reason of discontinuation was medical factors and IUD caused complication. The most common complication was bleeding.
Darioush Mohajeri , Ali Rezaie , Ghafour Mousavi, Mohammad Mazani, Adel Rezaei-Moghadam,
Volume 12, Issue 2 (summer 2012)
Abstract
Background & Objectives: The aim of the present study was to evaluate the protective effects of Crocin on rat high fat diet-induced hepatic steatosis model. Methods: For this purpose, male rats were given either standard diet as control, high fat diet for induction of hepatic steatosis and high fat diet plus Crocin through gavage at different doses (25, 50 and 100 mg kg-1/day) for protection of liver steatosis, at a period of 4 weeks in different experimental groups and compared considering serum lipid profile, serum biomarkers of liver tissue injury, hepatic antioxidant activity and liver histopathological changes. The serum levels of triglyceride, total cholesterol, low-density lipoprotein, very low-density lipoprotein, high-density lipoprotein for determination of deleterious metabolic effects, alanine aminotransferase, aspartate aminotransferase for determination of hepatocyte injury, alkaline phosphatase, bilirubin for assessment of biliary function, malondialdehyde and reduced glutathione content for assessment of liver free radical activity, the enzymatic activities of glutathione peroxidase, superoxide dismutase and catalase as indicators of antioxidation in liver tissue, were measured. Finally, the biochemical findings were matched with histopathological verifications. Results: After 4 weeks, high fat diet caused deleterious metabolic effects, including hypertriglyceridemia, hypercholesterolemia and liver dysfunction. Rats fed high fat diet alone showed increased activities of hepatocellular enzymes in plasma, significant decline in antioxidants, and elevated lipid peroxidation indices in liver. Crocin treatment significantly reduced elevated markers of liver tissue injury and malondialdehyde , and brought back the liver antioxidants and the over accumulation lipids in serum towards normal. Histopathology of the liver confirmed the changes induced by high fat diet and the heptoprotective effect of Crocin. Conclusions: Crocin exerts protective effects against hepatic steatosis in rats fed with high fat diet possibly through its antioxidant actions.
Fariba Sadeghi Movahed, Parviz Molavi , Mehdi Samadzadeh, Bita Shahbazzadegan , Raheleh Askari Moghadam ,
Volume 12, Issue 5 (suppl 2012)
Abstract
Background & Objective: Attention Deficit-Hyperactivity Disorder (ADHD) is a heredity and psychological disorder that often continues to adulthood and causes great number of emotional, social, educational and occupational problem for college students. The aim of this study is to determine the prevalence of ADHD among students residing in the dormitory of Ardabil University of Medical Sciences. Methods: In this cross sectional study, all students in the dormitory of Ardabil University of Medical Sciences were included. They filled the Self reporting Conner’s ADHD questionnaires. Data were extracted and analyzed with SPSS. Results: During this study, the prevalence of ADHD was 8.6 percent. The males show more involvement rate than females. The students with ADHD showed more incidences of smoking and psychotropic drug consumption. Conclusion: Due to the high prevalence of ADHD among the college students, early diagnosis and treatment of ADHD seems to be necessary.
Homayoun Ebrahimian, Seyied Mohammad Firoozabadi, Mahyar Janahmadi, Mehri Kaviani Moghadam,
Volume 13, Issue 2 (summer 2013)
Abstract
Background & Objectives: The development of technology has naturally given rise to an increase in environmental low-frequency electromagnetic fields and consequently has attracted scholars' attention. Most of the studies have focused on transmission lines and power system distribution with 50 Hz. This research is an attempt to show the effect of 50 Hz magnetic fields on bioelectric parameters and indicates the possible influence of this change in F1 cells of Helix aspersa . Methods: The present research used Helix aspersa neuron F1 to identify the location of magnetic fields as well as the rate of effects of environmental magnetic fields on nervous system. Control group was used to study the effect of elapsed time, electrode entering and the cell membrane rupture. Intuition group and environmental group were considered in order to study the potential impact of interfering environmental factors and identify the effectiveness rate of magnetic fields, respectively. For the purpose of producing uniform magnetic field Helmholtz coil was used. Electrophysiological recording was realized under the requirements of current clamp. And, in order to show the impacts from magnetic fields on ion channels Hodgkin-Huxley cell model was applied. All data were analyzed taking the advantage of SPSS 16 software and two-way ANOVA statistical test. P < 0.05 was considered as significance level. And MATLAB software environment and PSO were used in order for applying the algorithm and estimating the parameters. Result: No statistically significant difference was found between control and sham groups in different time intervals. Once the 45.87 microtesla was applied significant differences were observed 12 minutes after the application. The highest amount of change happened 14 minutes after the application of more fields. With the application of the field, the amplitude of the sodium action potential shows decreasing trend . No significant changes were observed in different time intervals, whereas significant differences were seen in frequency of action potential during different time intervals. The amplitude of AHP shows no significant changes . Conclusion: The results indicated that low-frequency magnetic fields with 50 Hz frequency will directly lead to change in bioelectric activities of neurons through a change in amount and rate of opening and closing of ionic channels and the conductivity of sodium and potassium channels reduces together with increase in conductance of potassium dependent calcium channel (AHP).
Maryam Adabi, Mahshid Talebi Taher , Leila Arbabi, Mastaneh Afshar , Sara Fathizadeh, Sara Minaeian, Niloofar Moghadam-Marageh, Ali Majidpour ,
Volume 15, Issue 1 (spring 2015)
Abstract
Background & objectives: Wound infection is a predominant cause of death in burned patients who are clearly at increased risk of nosocomial infections. Pseudomonas aeruginosa is the most common cause of burn infections and is difficult to treat because of having high level of resistance to antibiotics. The aim of this study was to perform isolation, identification and determination of antibiotics resistance pattern of P. aeruginosa strains isolated from wounds of hospitalized burn patient.
Methods: Biochemical and molecular tests were used for identification of the P. aeruginosa and antibacterial susceptibility test was performed using disk diffusion (Kirby- Bauer) methods. Then, the minimum inhibitory concentration (MIC) was performed for four representatives of different groups of antibiotics.
Results: Among 94 evaluated strains of P. aeruginosa, 83 isolates (88.3%) were multi drugs resistant. Based on Kirby-Bauer method, the most resistance was seen to cefepime (89.5 %) and among the antibiotics studied to determine the MIC, the most resistance was observed to ciprofloxacin (89 %).
Conclusion: These results indicate high range of resistance to different antibiotics among strains of P. aeruginosa isolated from burn wounds of patients. So, the fast and accurate measurement and evaluation of antibiotic resistance for appropriate antibiotic therapy of burned patients is imperative.
Mehdi Parsa Moghadam , Mohammadhossein Yazdani, Afshar Seyyedin, Manouchehr Pashazadeh ,
Volume 16, Issue 4 (winter 2016)
Abstract
Background & objectives: Construction of new service centers including hospitals is expensive and requires optimal site selection for these centers so that all citizens benefit from its increased productivity. It can also help them lower their costs. This study investigates the optimal locations for construction of hospitals in Ardabil using GIS software.
Methods: This is an applied research which incorporates a descriptive-analytic methodology. The data is made up of 11 criteria; proximity to densely populated areas, proximity to green space, closeness to main thoroughfares, proximity to fire departments and distance from existing hospitals, industrial centers, slopes, learning centers, cemetery, military bases and from sport facilities. They were all weighted using analytic network process (ANP) model.
Results: After performing the necessary calculations and evaluations, the highest and lowest weight of criteria belonged to the proximity to densely populated areas (0.229) and distance from the cemetery (0.033), respectively. According to the criteria weights and overlapping of layers, the most and least favorable locations for the establishment of hospitals were identified.
Conclusion: Results of the classification showed the best location for construction of hospitals in Ardabil city based on four municipal regions. In region one it belongs to the 8th, 5th, 2nd, and 11th districts in region two districts of 6 and 7 which cover southeastern edge of the city, in region 3 districts of 1, 2, 6, 7, 8 and 10 which contain the western part of the city, and in region four it belongs to districts of 1, 2, 6, 7, 10 and 11 that encompass the blocks in the northern and north-western route of the city. These regions can be used for construction of new hospitals in order to improve people’s access to healthcare services.
َarash Mehri Pirayvatlo , Reza Alipanah-Moghadam , Mohammad Mazani, Farideh Manafi, Vadood Malekzadeh, Ali Nemati, Abbas Naghizadeh Baghi ,
Volume 16, Issue 4 (winter 2016)
Abstract
Background & objectives: Iron overload is involved in the pathophysiology of many diseases including diabetes. In fact, the excess iron by creating free radicals makes damage to pancreas and leads to insulin resistance and diabetes. Andrographolide extract has hypoglycemic and antioxidant properties. This study has surveyed the effects of andrographolide on blood glucose and lipid profile in rats with secondary iron overload.
Methods: In this experimental study, 36 male Wistar rats were randomly divided into 6 groups: the healthy control group, secondary iron overload group, secondary iron overload groups treated with a dose of 3.5 and 7 mg/kg of andrographolide extract, and andrographolide groups treated with a dose of 3.5 and 7 mg/kg of extract. Iron and extract were injected for 6 and 12 days, respectively. Blood samples were taken for measurement of blood glucose and lipid profiles. Data were analyzed using ANOVA test.
Results: The pathological results of samples from liver of animals receiving iron showed that the iron was deposited in the liver tissues. Iron injection significantly increased blood glucose levels compared to healthy control group (p<0.05). In the iron overload group, andrographolide extract with a dose of 3.5 mg/kg or 7 mg/kg significantly decreased blood glucose levels (p<0.05). Iron injections did not increase the serum triglyceride and cholesterollevels. Injections of andrographolide extract with a dose of 3.5 mg/kg and 7 mg/kg, significantly decreased the cholesterol levels compared to iron receiving group (p<0.05).
Conclusion: Results of this study showed that the andrographolide with different doses may be effective in the treatment of diabetes by reducing serum glucose and cholesterol levels.
Reza Alipanah_moghadam , Sara Hosseinzadeh, Ali Nemati, Abbas Naghizadeh Baghi , Vadood Malekzadeh,
Volume 17, Issue 2 (summer 2017)
Abstract
Background & objectives: The relationship between dietary patterns and esophageal cancer has not been documented yet. However, recent studies have shown that the Western dietary pattern is associated with an increased risk of esophageal cancer. The current study was performed a comparative evaluation of the food habits and serum nitrate level in patients with esophageal cancer and healthy individuals in Gorgan city.
Methods: In a case-control study, 44 patients with esophageal cancer (the case group) and 44 healthy subjects (control group) were selected for one year in Gorgan city. Anthropometric factors were measured, and then demographic and dietary data were recorded using general and food frequency questionnaires (FFQs), respectively. Fasting blood samples from both groups were collected to measure serum nitrate levels. Data were analyzed by independent t-test, Chi-square, Fisher, and Monte Carlo tests.
Results: the mean weight, body mass index (BMI) and serum nitrate levels were statistically lower in the case group than in control group (p<0.05). Salt intake, smoking cigarette or hookah was higher in patients than in control group (p<0.05). Based on nutritional habits , consumption of bread , rice, saturated fats, hot tea, sausages and industrial soft drinks was statistically higher in the patient group than control group, but intake of vegetables, fruits, unsaturated fats, honey and grilled meat was lower in patients than control group (p<0.05).
Conclusion: Consumption of fast foods, hot tea and saturated fats may be associated with esophageal cancer. Serum nitrate levels were lower in patients than control group, probably indicating the need for further research in this field.
Roghayeh Eqbali Ziyarat , Shahrzad Ghiasvandian, Masoumeh Zakeri Moghadam , Anooshirvan Kazemnejad,
Volume 17, Issue 4 (winter 2017)
Abstract
Background & objectives: Appropriate nutritional behavior is effective in controlling many diseases such as cardiovascular diseases. This study aimed to determine the effectiveness of nutrition counseling in improving nutritional behavior, lifestyle and healthy nutrition in patients with myocardial infarction.
Methods: In this interventional study, 120 patients admitted to the cardiac care units of the hospital, were selected by convenience sampling method and randomly assigned into two groups. Data were collected using MEDFICTS and demographic questionnaires. After running the questionnaire, interventional group (n=60) with a score of more than 70 received nutritional counseling. After the end of nutritional counseling (3 sessions, 90 minutes), the subjects were re-evaluated for nutritional behavior. Data were analyzed using t-test in SPSS20 software.
Results: The mean age of the participants was 62.73±11.56 years, and 53.7% of them were female. The mean MEDFICTS scores before the consultation in the interventional group and control group were 43.2±14.8 and 43.5±18.2, respectively. The difference between the two groups was not statistically significant (p=0.3). The mean MEDFICTS scores at the end of the study in interventional and control groups were 13.14±62.6 and 23.3±2.24, respectively. This difference was significant between groups (p<0.001).
Conclusion: MEDFICTS scores improved in patients with myocardial infarction receiving nutritional counseling. It seems that the operation of nutritional counseling in patients with myocardial infarction can be effective in reducing the incidence of this disease
Farid Manafi , Reza Alipanah-Moghadam , Ali Nemati, Vadood Malekzadeh, ,
Volume 17, Issue 4 (winter 2017)
Abstract
Background & objectives: Andrographolide has potent antioxidant properties. There is still not a complete understanding of the antioxidant effects of andrographolide. In this study, the effect of andrographolide on the serum antioxidant activity of superoxide dismutase and catalase was investigated in the rats with secondary iron overload.
Methods: In this experimental study, 32 rats were divided into 4 groups of 8 each. The groups included: 1-Control 2- Receiving iron 3- Receiving iron treated with 7 mg/kg andrographolide 4- Receiving 7 mg/kg andrographolide. The serum activity of superoxide dismutase and catalase and serum level of malondialdehyde (MDA) was measured using colorimetric method. Prussian blue was used to evaluate iron deposition in liver.
Results: The results showed that iron was deposited in the liver. The activity of superoxide dismutase and catalase in the secondary iron receiving group, compared to control group, was significantly increased (p<0.05). The activity of catalase was significantly decreased in the group receiving iron and treated with andrographolide, compared to the control and iron receiving groups (p<0.05). Also, the activity of superoxide dismutase in the group receiving iron and treated with andrographolide decreased significantly compared to the iron receiving group (p<0.05). Serum levels of malondialdehyde in the iron receiving group were higher than the control group (p<0.05). Serum levels of malondialdehyde in the group receiving iron and treated with andrographolide, compared with the iron receiving group, showed a significant decrease (p<0.05).
Conclusion: Andrographolide (7mg/kg) reduced the serum activity of catalase and superoxide dismutase and malondialdehyde serum levels in rats with secondary iron overload.
Pirooz Pour Mohammad , Reza Alipanah-Moghadam , Firooz Amani, Ali Nemati , Vadood Malekzadeh ,
Volume 18, Issue 1 (spring 2018)
Abstract
Background & objectives: Due to the widespread use of zinc oxide nanoparticles (ZnO-NPs) and their possible unwanted effects in biological environments, we made an attempt to investigate the effect of ZnO-NPs on the blood lipid profile.
Methods: In this study, 24 male Wistar rats were used. The rats were randomly divided into three groups: control group, the group receiving ZnO-NPs at 25 mg/kg (ZnO-NPs 25 mg/kg) and the group receiving ZnO-NPs at 50 mg/kg (ZnO-NPs 50 mg/kg). The duration of the test was two weeks. The blood samples were taken and the serums were separated. Serum levels of triglyceride, cholesterol, VLDL, LDL and HDL were determined using standard kits and methods.
Results: Based on the findings of this study, serum levels of triglyceride and VLDL in both ZnO-NPs receiving groups were significantly increased in comparison with the control group (p<0.05). Also, the serum levels of HDL , LDL and LDL/HDL ratio decreased significantly in both ZnO-NPs receiving groups compared to the control group (p<0.05), while the serum cholesterol levels did not change compared with the control group.
Conclusion: Our results showed that 25 and 50 mg/kg doses of ZnO-NPs had both harmful (increase triglyceride and VLDL and reduction of HDL) and beneficial (reduction of LDL and LDL/HDL ratio) effects on the blood lipid profile.
Parviz Molavi, Mohammad Reza Mohammadi, Ali Khaleghi, Mehryar , Nadr Mohammadi Moghadam ,
Volume 18, Issue 2 (summer 2018)
Abstract
Background & objectives: Considering the importance of prevalence studies in disease management, this study was conducted to determine the prevalence of psychiatric disorders in children and adolescents in Ardabil province.
Methods: In this study, 1035 children and adolescents aged 6 to 18 were selected using cluster random sampling and examined with a digital version of the K-SADS in terms of psychiatric disorders. In the present work, 24 types of psychiatric disorders in children and adolescents were evaluated. Sampling was done in the general population and interviews were conducted at the door of the house. Assessments were carried out by experienced psychologists. The point and interval prevalence (with 95% confidence interval) were calculated for disorders. Data were analyzed using SPSS ( v.22) software.
Results: Hyperactivity, oppositional defiant, enuresis, and separation anxiety disorders had the highest prevalence in the studied sample. In contrast, psychosis, autism and panic disorders had the lowest prevalence. Depression had a moderate prevalence (1.7%) among other disorders. The overall prevalence of disturbances was 31.7%.
Conclusion: The prevalence of psychiatric disorders in Ardabil children and adolescents was high. According to this rate, etiologic studies are necessarily needed for disorders with have high prevalence and health systems should design and manage preventive plans for the general public.
Sepideh Ahmadi Sagerlou , Reza Alipanah-Moghadam, Ramin Salimnejad,
Volume 18, Issue 4 (winter 2018)
Abstract
Background & objectives: One of the most important diabetes complications is chronic renal failure. This disorder is one of the most important progressive renal problems that is closely associated with high mortality rate in diabetic patients. The purpose of this study was to evaluate the effect of conjugated blackcurrant extract and zinc oxide nanoparticles on histopathologic damages of kidney tissue in diabetic rats.
Methods: A total of thirty adult Wistar rats were used and they were randomly divided into the following six groups (n=5): control group; diabetic group (170 mg/kg alloxan); diabetic group treated with insulin (170 mg/kg alloxan & 10 U/kg insulin); diabetic group treated with ZnO nanoparticle (170 mg/kg alloxan & 8 mg/kg ZnO nanoparticle); diabetic group treated with extract (170 mg/kg alloxan & 150 mg/kg blackcurrant extract) and diabetic group treated with extract conjugated with ZnO nanoparticles (170 mg/kg alloxan & 8 mg/kg blackcurrant extract conjugated with ZnO nanoparticle). Diabetes mellitus was induced by intraperitoneal injection of alloxan monohydrate. Conjugated blackcurrant extract and ZnO nanoparticles were produced using green synthesis method. The tissues were stained with hematoxylin and eosin stain. Image J software was used for evaluation of histopathological changes.
Results: The comparison between groups treated with blackcurrant extract, ZnO nanoparticles and blackcurrant extract conjugated with ZnO nanoparticle showed that these compounds somewhat protect kidney tissue from diabetes damage . The highest protective effect was observed in diabetic group treated with ZnO nanoparticles conjugated with blackcurrant extract.
Conclusion: Our study, for the first time, showed that the conjugation of blackcurrant extract to ZnO nanoparticles can be effective in preventing renal- tissue damage in diabetic patient.
Abbas Fadaii, Ali Majidpour, Soleymanzadeh Moghadam , Hamideh Rahmani Seraji ,
Volume 18, Issue 4 (winter 2018)
Abstract
Background & objectives: Asthma is one of the most common chronic diseases in the world and Iran. Despite appropriate treatment, recent researches indicate that asthmatic patients have poor asthma control. The aim of this study was to determine the correlation between educational level of asthmatic patients and asthma control indices.
Methods: This retrospective cross-sectional study was performed on 80 asthmatic patients admitted to Shahid Labbafinejad hospital. ESMAA questionnaire was used to collect data to assess the level of asthma control, according to ACT (Asthma Control Test) and 2016 GINA (the Global Initiative for Asthma) guidelines. Patient medication compliance was evaluated based on Morisky medication adherence scale (MMAS). ANOVA test (Regression and Pearson correlation) and Chi-Square test were used for analysis of quantitative and qualitative variables, respectively. The P - value less than 0.05 was considered statistically significant.
Results: Eighty asthmatic patients with an average age of 54.65 were entered to this study that of them 32 patients were at primary school level, 26 patients at high school level and 22 patients at university state. According to ACT test, 52.5% and 47.5% of patients were in control and uncontrolled state, respectively.
According to GINA classification, 30% of patients were in control, 45% in partially control and 25% in uncontrolled state. According to MMSA scale, 20% of patients were high adherent to medicine, 40% were moderate adherent and 40% were low adherent. In this study, there was no significant correlation between the asthma control in terms of ACT and patients' educational level. Also, there was no significant relationship between sex, asthma control and medication adherence. In addition, there was no significant relationship between educational level and drug adherence.
Conclusion: The results suggest that there was no relationship between asthma control indices and patient's educational level. Perhaps other factors, other than education, affect the asthma control indices and medication adherence which requires more studies.
Hasan Ghobadi, Somaieh Matin, Ali Nemati, Hasan Javadi , Reza Alipanah-Moghadam , Mehdi Saeidi-Nir ,
Volume 19, Issue 1 (spring 2019)
Abstract
Background & objectives: Chronic Obstructive Pulmonary Disease (COPD) is accompanied by systemic inflammations and is characterized by irreversible airflow limitations. Leptin is a cytokine with pre-inflammatory effect. However, there have been no studies on the effect of conjugated linoleic acid (CLA) on the serum leptin concentration in COPD patients. Therefore, the present study aimed to explore the effect of CLA on the serum leptin level, lung function and quality of life in COPD patients.
Methods: This interventional study was conducted on 90 COPD patients. The patients were randomly divided into two groups (supplement and placebo) with 45 patients per group. After obtaining written consent from the patients and recording their demographic characteristics, the spirometry was performed and COPD assessment test (CAT) score was calculated. Moreover, a fasting blood sample was collected from each of them in order to analyze their serum leptin concentration. After that, the patients in the supplement group were administered with 3.2 g/day of CLA for 6 weeks. The patients in another group received placebo. After the intervention, spirometry, CAT score calculation and blood sampling were repeated for all of the patients and the obtained results were analyzed.
Results: after the intervention, a significant decrease both in the serum leptin level and in CAT score as a quality life marker was observed in the supplement group (p<0.05). Moreover, the FEV1 levels as a lung function test, increased significantly in the supplement group after the intervention (p<0.05). Although, the difference between the two groups was not significant.
Conclusion: The use of CLA supplement can improve COPD patients’ quality of life through decreasing the serum level of leptin in their blood.
Afsaneh Mafi, Abbas Moghadam, Nilofar Moghadam,
Volume 19, Issue 4 (winter 2019)
Abstract
Background & objectives: Nephrotoxicity is the most important side effect of gentamicin and is a concern in clinical situations. There are no therapeutic tools to prevent or palliate nephrotoxicity. Platelet-rich plasma (PRP) as a source of growth factors can be considered as a therapeutic tool. Therefore, the aim of this study was to investigate the effects of PRP on proliferation of epithelial cells of convoluted tubules in gentamicin-treated rat model by stereological method.
Methods: 28 male rats (200-300g) were divided into four groups, each group containing 7 animals: control, patient without treatment, sham and experimental groups. Gentamicin was injected intraperitoneally (80mg/kg/daily) for 8 days. 24 hours after the last injection, blood samples were collected to assess the serum levels of blood urea nitrogen and creatinine. The sham and experimental animals were subjected to intrarenal injection of 100 µl normal saline and PRP, respectively. 3 days later, the rats scarified under the deep anaesthesia and their kidneys were removed, prepared histologically and stained. The stereological methods were used for estimating the number of epithelial cells in convoluted tubules. Data analysis was done using SPSS 26. Differences between groups were compared with one-way analysis of variance and Duncan’s multiple range test. p<0.05 was considered as significant.
Results: PRP increased the number of epithelial cells in the convoluted tubules in gentamicin-treated animals (p<0.05).
Conclusion: It seems that PRP can induce proliferation of epithelial cells of convoluted tubules in gentamicin-treated rat model.
Dr Yousef Fekri, Dr Habib Ojaghi, Dr Telma Zahirian Moghadam, Dr Afshan Shargi, Dr Arezoo Ranjbar, Talma Zahirian Moghadam ,
Volume 20, Issue 1 (spring 2020)
Abstract
Background & objectives: Cataract is the most common cause of blindness in the world and it is estimated that about 100,000 cataract surgeries are performed annually in Iran. The aim of the present study was to determine the prevalence of different morphological types of cataract and some related causes in patients undergoing surgery at Noor Surgery Center in Ardabil.
Methods: This descriptive cross-sectional study was performed on 780 patients referred to the Noor ophthalmology clinic in Ardabil with cataract diagnosis. The data were collected using a checklist by the researcher. Data analysis was performed using SPSS 25 software and descriptive statistical methods.
Results: Of the 1,018 eyes (780 patients), 590 eyes (58%) were related to women and 428 eyes (42%) were related to men and the mean age of all patients was 65.88±11.43. the mean grade of posterior subcapsular cataract (PSC), nuclear and cortical cataracts were 4.56±0.62, 4.79±0.89 and 4.21±0.48 respectively. There was a significant difference between normal retina diabetics (p=0.034), pseudo exfoliation syndrome (PEX) (p=0.001), hyperopic (p=0.008), corneal opacity (p=0.036) and patients with nasolacrimal duct obstruction (NLDO) (p=0.032) and other patients in terms of cataract type (p=0.034). There was no significant relationship between other comorbidities and cataract type.
Conclusion:According to the results of the present study based on the significant relationship of some diseases with different morphological types of cataracts, accurate preoperative
evaluation and planning for associated comorbidities is recommended.
|
|
.png)
.png)
