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Background & objectives: Using medications that decrease postoperative pain and opioid consumption is a widely recommended approach. The aim of this study was to evaluate the efficacy of intravenous Ibuprofen and its complication in controlling pain after abdominal surgery.
Methods: This study was a randomized, double-blind, interventional clinical trial. Sixty patients aged 20 to 60 years were candidates for abdominal surgery (inguinal hernioplasty and appendectomy). Patients were divided into two equal size groups (n=30) using a random block design method. The First group received (400 mg IV) ibuprofen every 6 hours for 24 hours as well as (15 microgram/ml bolus) fentanyl pump with PCA. Second group only received (15 microgram/ml blous) fentanyl pump with PCA. 
Results: Demographic characteristics and duration of surgery, ASA class, type of anesthesia and type of surgery were similar in the two groups. Pain severity in 24 postoperative hours was significantly lower in the ibuprofen group compared with the control group. Nausea and vomiting frequency in 24 postoperative hours was significantly lower in the ibuprofen group compared with the control group. Patients belonging to ibuprofen group were significantly more satisfied with their analgesic method.
Conclusion: Results showed that using 400 mg intravenous ibuprofen every 6 hours mitigates postoperative pain, reduces fentanyl consumption and is highly tolerated by patients.

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Background & objectives: There is evidence that COVID-19 may have some long-term effects on the patients' blood biochemical and hematological factors. The purpose of this study was to investigate and compare the changes in biochemical and hematological factors in adults with and without past history of COVID-19.
Methods: The present study is a cross-sectional study including 72 cases with a past history of COVID-19 (PCR+ test) and 52 controls without a history of COVID-19. All participants were from two prospective cohort studies, namely Yazd Health Study (YaHS) and Shahedieh Cohort Study. Biochemical parameters such as blood glucose, lipid profiles, liver, kidney and hematological factors of cases and controls were extracted from the databases and analyzed.
Results: The mean red blood cell count in patients with COVID-19 was significantly higher than in non-COVID-19 patients (p<0.05), and mean corpuscular volume (MCV) was significantly lower in patients with COVID-19 (p>0.001). However, no significant difference was found between the two groups in terms of lipid and kidney profiles and liver enzymes.
Conclusion: No significant difference was found between the two groups of patients exposed to COVID-19 and patients not exposed to COVID-19 in terms of liver enzymes, lipid and kidney profiles, which probably indicate that COVID-19 has no long-term effect on these variables. However, a significant difference was observed between the two groups (p<0.05) regarding the number of red blood cells and MCV.