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Background & objectives: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world which is associated with cardiovascular disease. The aim of this study was to investigate the plasma changes of chemerin and pentraxin-3 (PTX3) following 8 weeks of endurance training in men with NAFLD.
Methods: In this quasi-experimental Study, thirty four patients with NAFLD were selected purposefully. The participants were randomly divided into two groups, endurance training group (n=17) and control group (n=17). The endurance training program included eight weeks running on a treadmill with maximum heart rate (HRmax) intensity of 55-75% for 45 minutes three times a week. Seventy two hours before the beginning of the study and at the end of the eighth week, blood samples were taken from all the participants. The data were analyzed by paired sample t-test and independent t-test at the significant level p<0.05.
Results: Plasma levels of chemerin in the endurance training group significantly decreased (p=0.013). Also, there was a significant difference between the two groups after the end of the intervention (p=0.002). Plasma levels of PTX3 increased significantly in the endurance training group (p=0.001). There was also a significant difference between two groups after the end of the intervention (p=0.01).
Conclusion: The present study showed that the 8-week endurance training increased the plasma levels of PTX3 and decreased the plasma levels of chemerin in men with NAFLD. Endurance training, possibly through various mechanisms, reduces the inflammatory factors and increases the anti-inflammatory factors in men with NAFLD. Endurance training, probably by activation of lipolysis, over-regulation of unpaired protein-1 and activator receptors of peroxisomes proliferation-, changes in adipocytokines, etc. decreases charmicin and increases PTX3 levels of plasma in men with NAFLD.
 

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Background & objectives:  with Regard to the increasing prevalence of nonalcoholic fatty liver disease (NAFLD), focusing on various strategies for its prevention and management seem necessary. The purpose of this study was to investigate the effect of running on treadmill and low calorie diet on visfatin and hs-CRP values in people with NAFLD.
Methods: In this quasi-experimental Study, 55 NAFLD patients were selected and randomly assigned to one of four groups: training (n=14), diet (n=14), training plus diet (n=14) and control (n=13). The training program included eight weeks running on a treadmill with maximum heart rate intensity of 55-75% for 45 minutes three times a week. A low calorie diet with an energy deficit of 500 calories of daily energy intake was calculated from 3-day food records of the patients. Combined group subjects also used both types of intervention. Data were analyzed using covariance analysis and Bonferron's post hoc test at a significance level of p<0.05.
Results: Visfatin values in the training group (p=0.01), in the combined group (p=0.001) and also hs-CRP values in the training group (p=0.003) and the combined group (p=0.008) decreased significantly. The body mass index of subjects was significantly decreased by training (p=0.003) and combined intervention (p=0.001).
Conclusion: Running on treadmill and a low calorie diet simultaneously reduce the plasma levels of visfatin and hs-CRP in male patients with NAFLD. Therefore, these therapeutic interventions are beneficial in reducing NAFLD inflammatory factors.