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  Background & Objectives: Low dose aspirin has been widely used in the prevention and treatment of cardiovascular disease. The bimodel action of aspirin on serum uric acid showed that aspirin at a high dosage promoted uricusuria while intermediate doses were (1-2gr/day) caused uric acid retention. The main goal of this study was to survey the effect of low dose aspirin on serum level of uric acid in patients with ischemic heart disease.

  Methods: The study design was cross-sectional and analytical type. In this study we selected 60 patients who used low dose aspirin among the patients of Imam Khomeini hospital's heart clinic (2008-9) and their information was registered in special questionnaires including serum level of uric acid and creatinine before and after prescription of aspirin. Data was then statistically analyzed using Paired t test and Willcoxon.

  Results: Of 60 patients 11 ( 18.3 % ) were under 50 years and 49 ( 81.7%) were above 50 years. The male to female ratio was 1.72 (38: 63.3% versus 22: 36.7%). 53.3 % of patients showed an increase in serum uric acid, but 46.7% did not. No significant differences in uric acid levels was found in patients under 50 years before and after administration of aspirin. Serum uric acid levels were increased after administration of 0.1unit of aspirin.

  Conclusion: Low -dose aspirin (80 mg/ day) caused a slight but significant increase in serum uric acid and creatinine levels in patients over 50 years of age.

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Background & objectives: Nephrotoxicity is the most important side effect of gentamicin and is a concern in clinical situations. There are no therapeutic tools to prevent or palliate nephrotoxicity. Platelet-rich plasma (PRP) as a source of growth factors can be considered as a therapeutic tool. Therefore, the aim of this study was to investigate the effects of PRP on proliferation of epithelial cells of convoluted tubules in gentamicin-treated rat model by stereological method.
Methods: 28 male rats (200-300g) were divided into four groups, each group containing 7 animals: control, patient without treatment, sham and experimental groups. Gentamicin was injected intraperitoneally (80mg/kg/daily) for 8 days. 24 hours after the last injection, blood samples were collected to assess the serum levels of blood urea nitrogen and creatinine. The sham and experimental animals were subjected to intrarenal injection of 100 µl normal saline and PRP, respectively. 3 days later, the rats scarified under the deep anaesthesia and their kidneys were removed, prepared histologically and stained. The stereological methods were used for estimating the number of epithelial cells in convoluted tubules. Data analysis was done using SPSS 26. Differences between groups were compared with one-way analysis of variance and Duncan’s multiple range test. p<0.05 was considered as significant.
Results: PRP increased the number of epithelial cells in the convoluted tubules in gentamicin-treated animals (p<0.05).
Conclusion: It seems that PRP can induce proliferation of epithelial cells of convoluted tubules in gentamicin-treated rat model.