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  Background: Co-inheritance of hemoglobin gene defects is a rare important status that can lead to double heterozygote or homozygote with significant clinical manifestations. Such conditions can be observed in co-inheritance of alpha-thalassemia with beta-thalassemia or hemoglobinopathy. The aim of this study was to evaluate the prevalence of alpha-thalassemia with beta-thalassemia and hemoglobinopathy co-inheritance in a considerable number of Iranian.

  Methods: This descriptive study was performed on patients with abnormal hematological findings in favor of alpha-thalassemia, beta-thalassemia or beta-hemoglobinopathies. Patients with low MCV and MCH levels and high HbA2 (>3.5) and those with low MCV and MCH and normal or low HbA2 were candidate for molecular analysis for beta and alpha thalassemia respectively. Abnormal Hb electrophoresis was diagnostic criteria for molecular analysis of beta-hemoglobinopathies.

  Results: Study revealed that more than half of the patients with alpha-thalassemia affected simultaneously by beta-thalassemia and about thirty percent inherited beta-hemoglobinopathies. Among patients with beta-thalassemia, HbSCd6 (A-T) was the most common mutation and in alpha-thalassemic patients α ^3.7 was the commonest mutation.

  Conclusion: Relatively high prevalence of co-inheritance of alfa-thalassemia with beta-thalassemia and hemoglobinopathies reflect the necessity of genetic consulting and molecular analysis in diagnosis of such conditions.

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  Background & objectives: Ischemic stroke remains the third leading cause of invalidism and death in industrialized countries. It is suggested that renin–angiotensin system (RAS) may contribute in stroke related pathogenic mechanisms and involve in the ischemic brain damage. This study designed to investigate the role of angiotensin II (Ang II) in conjunction with AT₁ receptors in treatment of the brain injuries following transient focal cerebral ischemia in rats.

  Methods: Forty eight male Sprague-Dawley rats were studied in four groups. Sham group, ischemic control group and two ischemic groups that received candesartan (0.1mg/kg, or 0.5mg/kg) at the beginning of reperfusion period. Transient focal cerebral ischemia was induced by 60 minutes occlusion of the middle cerebral artery, followed by 24 hours reperfusion. At the end of the reperfusion period, neurological deficit score (NDS) was performed. Total cortical and striatal infarct volumes were determined using triphenyltetrazolium chloride (TTC) staining technique.

  Results: Animals in sham operated group had normal motor function and no ischemic lesions were observed in cortical or striatal regions. Occurring ischemia in ischemic control group that received vehicle produced considerable infarction in cortex (253±15mm³) and striatum (92±7mm³), as well as these animals had sever impaired motor dysfunctions. Blocking of AT1 receptors with candesartan (0.1mg/kg or 0.5mg/kg) improved neurological outcome and significantly lowered cortical and striatal infarct volumes relative to ischemic control group.

  Conclusion: The findings of the present study indicated that stimulation of AT1 receptors by Ang II involved in ischemia/reperfusion injuries and blocking of AT1 receptors can decrease ischemic brain injury and improve neurological outcome.

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  Background & objectives: Intestinal parasitic infections are the most health threatening agents around the world, developing countries in particular. The aim of the present study was to determine the prevalence of Giardia lamblia and Enterobiusvermicularis among the children of kindergartens in Shahroud, Iran.

  Methods: In this descriptive cross sectional study from 811 children of 15 kindergartens fecal samples were collected by way of census in 2013. Thisworkwas conductedwith education of parentsandtheirfull consent . All samples were examined at Central Laboratory of Shahroud University of Medical Sciences based on formalin ethyl acetate method. In addition direct smear was also applied for the watery and loose samples. Finally, collected scotch tape samples were examined microscopically. Descriptive statistics indices including means , standard deviations, and frequencieswere used for reporting the results .

  Results: The overall prevalence of intestinal parasitic infections among the children of Shahroud's kindergartens was 22.2%. Also, the prevalence of the infections among males and females were 24.1% and 20.4%, respectively. The highest prevalence of infections were belongs to Giardia lamblia and Endolimax nana (7.4 and 4.8%), respectively. Also, Trichomonashominis had the lowest prevalence (0.5%). Prevalence of infection caused by Enterobiusvermicularis was (2.1%), the average agesof children infected by Enterobiusvermicularis and Giardia were 5.1 and 4.7, respectively. There was no difference in order of parasites infection on the basis of gender.

  Conclusion: The prevalence of infection caused by Enterobiusvermicularis among the children was considerably low. Also, the prevalence of Giardia lamblia was lower than the average of its prevalence in countrywide scale. Although the health services have been effectively enhanced, the prevalence of intestinal parasites, Giardia lamblia in particular, is still problematic.

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Background & objectives: In recent years، Computed Tomography (CT scan) has become the Gold Standard for detecting urinary stones. This study was conducted to predict the size of possible passage of ureteral stones based on clinical signs, lab data (e.g. Ultrasounds) in patients with small passable stones and to prevent CT scan, which requires high costs and x-ray exposure.
Methods: In this cross- sectional study, fifty consecutive patients from emergency room who had clinical symptoms of renal colic and urinary tract stones were recruited by simple non-random sampling. After obtaining the primary data, all of them underwent sonography (US), and in those without sings of stone in US، CT scan was performed. Based on the CT scan, the patients were divided into two main groups: 1) patients who had no ureteral stones or had ureteral stones <5mm, and 2) patient who had ureteral stones ≥5mm. All gathered data were analyzed by t-test and chi-square test.
Results: Among our proposed variables, previous history of urinary stone (p=0.05), irritative urinary symptoms (e.g. dysuria, frequency and urgency) (p=0.001), gross hematuria (p=0.049) and degree of hydronephrosis (p=0.029) had statistically significant relationship with the presence, size and spontaneous expulsive potential of ureteral stones.
Conclusion: Based on our results, negative history of urinary stones, absence of irritative urinary symptoms and gross hematuria and absence or mild degree of hydronephrosis in sonography were in favor of small (<5mm) or passable ureteral stones for which CT scan can be omitted.