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Showing 4 results for Asgarzadeh
Mohammadreza Nahaei , Reza Bohloli Khiavi , Mohammad Asgarzadeh, Alka Hasani , Javid Sadeghi, Mohammad Akbari Dibavar ,
Volume 7, Issue 1 (spring 2007)
Abstract
Background and Objectives: Pseudomonas aeruginosa is a nosocomial pathogen that presents high antibiotic resistance.There are phenotyping and genotyping methods for epidemiologic study of Pseudomonas aeruginosa such as antibiotic resistance pattern and plasmid profile analysis. Plasmid analysis provides useful information concerning the source of the strains and number of clones present in the epidemies. Thus, this study was conducted to evaluate antibiotic and plasmid profiles of P. aeruginosa strains isolated from in-patients of the Sina Medical Centre of Tabriz to clarify epidemyological correlation among isolated strains. Methods: During 13 months, 135 strains of P. aeruginosa were isolated from different infections in hospitalized patients at Sina Medical Center of Tabriz. Antibiotic susceptibility tests were performed using disc agar diffusion test. For plasmid DNA extraction and detection of open circular bands from supercoiled ones, modified alkaline lysis procedure and two dimensional electrophoresis were used, respectively. Enzymatic digestion of plasmids was carried out by EcoRI and HincII restriction enzymes. Results: Resistance rates of strains against antibacterial agents were recorded as: Aztreonam (77%), colistin (74%), ceftazidime (69%), pipracillin (67%), ofloxacin (62%), tobramycin (56%), carbenicillin (54%), gentamicin (51%), ciprofloxacin (22%), amikacin (15%), polymixin B (13%) and imipenem (2%). Plasmid profiles of our test strains revealed that only 67 strains harbored plasmid(s). Number of isolated plasmids ranged 1-6 in each strain with molecular mass of 0.5kb-21kb. When the isolated plasmids were digested using restriction endonuclease enzymes (EcoRI and HincII), in 32% of them similar digestion profiles were obtained by EcoRI indicating a unique source for them. Conclusion : Our findings suggest high antibiotic resistance and plasmid presence in P. aeruginosa strains isolated from different infections, and there were remarkable similarities among isolated plasmids. Since our test strains had been isolated from various wards in a short period of time, the results raise the possibility of unique source for some strains or high prevalence of genetic exchange among P. aeruginosa strains.
Bahram Pourghassem Gargari , Parvin Dehghan, Elham Mirtaheri, Akbar Aliasgarzadeh,
Volume 13, Issue 4 (Winter 2013)
Abstract
Background & Objectives: Diabetes mellitus is a metabolic disease characterized by hyperglycemia together with biochemical alterations of lipid profile, insulin resistance and inflammation . Considering the high prevalence of hypertension, dyslipidemia and inflammation in type 2 diabetic patients, the aim of the present study was to investigate the effects of inulin on lipid profile, inflammation and blood pressure in women with type 2 diabetes. Methods: In this controlled, randomized clinical trial, 49 women with type 2 diabetes (fiber intake<30 g/d, BMI=25-35 kg/m2) were assigned to one of two groups. Experimental group (n=24) received 10 g/d inulin and control group (n=25) received 10 g/d maltodextrin for 8 weeks. Dietary intakes, anthropometric measurements, blood pressure, serum lipids and hs-CRP concentrations were measured at the baseline and at the end of the study. Data were analyzed using SPSS software (verision11.5). Paired, independent t-tests and ANCOVA were used to compare quantitative variables. Results: At the end of study, there was a significant decrease in systolic blood pressure (from 135.7 ± 16.2 to 125.9 ± 7.9 mmHg), total cholesterol ( from 192.5 ± 42.8 to 171.0 ± 39.7 mg/dl), triglyceride ( from 223.3 ± 84.2 to 169.9 ± 65.6 mg/dl) and hs-CRP ( from 7.9 ± 3.0 to 5.3 ± 3.0 mg/l) in inulin group compared with the maltodextrin group (p > 0.04 ). Changes in diastolic blood pressures, LDL-c and HDL-c were not significant in inulin group compared with the maltodextrin group. A significant decrease in systolic, diastolic blood pressures, total cholesterol, triglyceride, LDL-c, hs-CRP and significant increase in HDL-c were observed in inulin group compared to baseline. Conclusions: Inulin supplementation may improve lipid profile, hs-CRP and blood pressure in women with type 2 diabetes.
Shafagh Aliasgarzadeh, Sevda Mikaeili Mirak, Javad Aliasgarzadeh, Hamed Aghazadeh, Seraj Mohajeri, Nima Javanshir, Mohammad Negaresh,
Volume 23, Issue 3 (Autumn 2023)
Abstract
Background: Diabetes is a significant risk factor for postoperative complications and mortality. However, there are different opinions about the relationship between the increase in glycosylated hemoglobin (HbA1c) level and the incidence of surgical complications.
Methods: In this retrospective study, 189 diabetic patients referred to Sabalan Hospital in Ardabil who were admitted for surgery were examined in 2021. The data related to demographic information, HbA1c test, postoperative complications, and the outcome of patients’ hospitalization were extracted from the records and entered into the researcher-made checklist. Patients were divided into two groups of uncontrolled diabetes with HbA1c of 7 and above and the controlled diabetes group with HbA1c below 7.
Results: Out of 189 patients included in the study, 97 patients were in the uncontrolled diabetes group, and 92 patients were in the controlled diabetes group. The average age of diabetic patients in uncontrolled and controlled diabetes groups was 58.18±8.91 and 61.84±5.52, respectively. According to the results, surgical site infection and the need for re-surgery during hospitalization showed a significant relationship with an HbA1c level (p≤0.05). Other postoperative complications were not significantly different between the two groups.
Conclusion: It seems logical that elective surgeries should be postponed in HbA1c levels higher than 7% because the presence of high HbA1c levels indicates that the patient’s diabetes is not under control, and as a result, there is a higher probability of chronic complications of diabetes as well as a higher risk for post-operative complications.
Ali Eskandari, Atabak Sedigh-Namin, Shafagh Aliasgarzadeh, Sara Jalalijivan, Saeid Sadeghieh Ahari,
Volume 24, Issue 4 (Winter 2025)
Abstract
Background: Vasculitis is the inflammation of blood vessel walls, which may lead to vessel damage, narrowing, or occlusion. To better understand the impact of the environment and social factors on the development of vasculitis, more studies need to be conducted in different regions. Early diagnosis based on the prevalence of vasculitis helps in the management and treatment of these patients and prevents irreversible damage, which highlights the importance of diagnosing Vasculitis diseases.
Methods: In this cross-sectional, descriptive study, we evaluated 152 patients who were referred to the Rheumatology Clinic of Imam Khomeini Hospital of Ardabil during the years 2018-2023. The required information was collected by reviewing the patients' medical records in the hospital archive. The relevant information was entered into SPSS software version 22 and evaluated based on the research objectives.
Results: Data from 152 patients were analyzed. Behcet's disease (68.2%) and Wegener's granulomatosis (11.3%) were the most frequent diagnoses. Female patients comprised 53% of the group, with an average age of 36.8 years. Giant cell arteritis patients had the highest average age, while Behcet's patients had the lowest. Most patients resided in Ardabil city and were housekeepers or agricultural workers. Common symptoms included carotid disease and pulse reduction in Takayasu's arteritis, temporal tenderness in giant cell arteritis, weakness and myalgia in polyarteritis nodosa, shortness of breath in Churg-Strauss syndrome, hemoptysis in Wegener's, and mouth sores in Behcet's. ESR and CRP levels were highest in giant cell arteritis compared to other vasculitis types.
Conclusion: Behcet's and Wegener's were the most common vasculitis types. Symptoms varied by disease but often included general signs like fever and myalgia. Elevated ESR and CRP were consistent across cases, with imaging and pathology being key diagnostic tools
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