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Showing 21 results for Alizadeh
Nategh Abbasgholizadeh , Manoochehr Barak , Mehrdad Mirzarahimi , Esmaeil Valizadeh- Haghi ,
Volume 3, Issue 1 (spring 2003)
Abstract
Background & Objective : The fast population growth is one of the basic problems in Iran and using family planning devices has a remarkable role in decreasing it. The findings of researches carried out nationwide indicate the effectiveness of instruction in the application of family planning methods and devices. The objective of this study is determining the level of knowledge of 15-49 year-old women under Ardabil health and treatment center services. Methods : 138 qualified mothers were chosen randomly from among 15-49 year-old women under Ardabil health and treatment centers services. These subjects were selected from among 14 centers (10 mother from each center) and had secondary school level of education. This descriptive cross-sectional and prospective research was conducted by filling out the pre-planned questionnaire and preparing educational booklets and giving them to the mothers under the study as pretest and post-test procedures during the time span of December 2000 to May 2001. Results : No meaningful relationship was found between employment and utilizing family-planning devices. The results of Mc-Nemar test and t-test showed that statistically the instruction given with regard to the method of beginning to take anti-gestation pills, method of the intervals of taking the anti-gestation pills, taking measures at the time of forgetting to take anti-gestation pills, the preference of vasectomy to tobectomy, the interval between the injection of anti-gestation ampoules and the duration of IUD effectiveness before and after studying the manuals demonstrated a significant difference. Conclusions : Education plays an important role in increasing the knowledge level of the population under study and hence it improves their performance about family planning. So this instruction is recommended to be followed seriously.
Seid Hadi Hakim, Gahanbachsh Samadikhah , Samad Gafari , Azin Alizadeh ,
Volume 6, Issue 1 (spring 2006)
Abstract
Background & Objectives: Thrombosis with high mortality is a serious complication of prosthetic heart valves and requires treatment, which includes reoperation or using filbrinolytic medications. Regarding the importance of the issue and high mortality rate in reoparation, the present study was performed to determine the efficacy and pragnosis of fibrinolytic therapy on mechanical prosthetic valve. Methods: This prospective study was preformed on seventeen patients with PVT who had undergone treatment with streptokinase (SK). After the primary diagnosis, the response to treatment was echocardiography and TEE. Patients with large clots or equal to 1cm clots, pregnant women and patients who had been operated in a month prior to the study were excluded. Results: Of the 17 patients (9 female and 8 male, mean age= 43.8 ± 11) 14 had mechanical double-let prostheses (8 mitral & 6 aortic) and 3 patients had single-let prostheses (1 aortic and 2 mitral). 71.3% of the patients with a double-let prosthesis responded completely to the treatment with SK. In none of the patients with a single-let prosthesis the treatment was successful. Also treatment of acute thrombosis was more effective in aortic position (71.4%) than in mitral– valve (50%) (p=0.02). Mortality rate due to cerebral bleeding was 5.8%. Two systemic embolic events (11.8%) occurred (1 cerebral and 1 renal) with transient signs. Conclusion: The use of fibrinolytic agents was effective, relatively safe and available especially in patients with less than two weeks’ presentation, small clot and NYHA class I and II and in aortic-position thrombosis.
Siyavash Savadi Oskuee, Parnian Alizadeh Oskuee, Narmin Mohammadi , Soodabeh Kimiaie, Hosein Vatandoost ,
Volume 7, Issue 1 (spring 2007)
Abstract
Background and purposes: Because of huge growth of snack food industry in the last few years the nation’s eating habits are undergoing major transformation with a replacement of traditional main meals by more frequent snacking. Dietary changes have been notable in children and particularly students so they are the major consumers of these foods. The aim of this study was to evaluate the snack and sweet drinks consumption at school times and its relationship with first molar cavities level in a group of students . Methods: The study was carried out in a group of 400, 8-12 year-old boy students in Area 5 Tabriz school. Data were collected through simple examination and questionnaire completed by a interveiwer. Findings were analyzed with descriptive statistic methods and chi-square Test . Results: The findings showed that nearly all the students (91%) had one or more snack or sweet drinks at school time. Biscuits, dried berries and raisins and packed fruit juice were the most popular. First molar cavities as expressed in DMFT increased significantly with high intake of snacks. Conclusion: Snack and sweet drinks consumption is high among Tabriz students, and first molar cavities level is increased with high snacks intakes.
Parnian Alizadeh Oskoee, Siavash Savadi Oskoee, Mahdi Abed Kahnamuee, Moharram Baghery Paridlu,
Volume 7, Issue 3 (Autumn 2007)
Abstract
Background & Objectives: Vast usage of Amalgam and it's poisoning nature related to mercury necessited the hygiene aspects of mercury to be put in to consideration. The aim of this study was to assess knowledge, attitude and practice of dentists towards the principles of mercury hygiene. Methods : In this descriptive analytic study, 116 dentists in their private clinic were selected randomly and were analyzed for the above parameters by questionnaire. Data were analyzed in spss.14/win software with descriptive statistic methods, t test and Pearson correlation test. Results : The mean of knowledge, attitude and practice of dentists were 45.74±13.28, 68.96±10.62 and 17.43±17.55 respectively. There was no statistically significant correlation between the knowledge and attitude and practice of principles of mercury hygiene. Besides there was no significant correlation between sex, specialty and graduation time with those parameters. Conclusion: Despite positive attitude and knowledge, practice of Tabriz dentists is not favorable. According to the positive attitude and the willingness of the dentists for knowledge enhancement and optimizing the practice for mercury hygiene, appropriate programming for mercury hygiene instruction during the educational period and continuing educational program can be very advantageous.
Salman Alizadeh, Hamid Samvat, Mohammad Taghi Samadi,
Volume 8, Issue 3 (Autumn 2008)
Abstract
Background & Objectives: One of the main areas of research in hot springs is to investigate the probability of the presence of gamma radiation resulting from the natural radioactivity substances in geologic combinations in volcanic regions. Meshkinshahr with a beautiful landscape is located in the northwest of Iran. Sabalan volcanic mountain has created many hot springs in its vicinity. One of the major ones is hot spring of Qotursui with PH= 2.5 n the north east, chainarja with an average temperature of 80 0c and Ilando and moillsui in the northwest of sabalan. This study was done to determine the environmental gamma and the annual absorption dose for the above hot springs and to compare it with that of world standard in Meshkinshahr in 2007-2008. Methods: In this descriptive cross sectional study, a Geiger Muller dose meter (Model: Smart Ion) was used to measure the amount of environmental gamma. Placing the dose meter in two different heights of 1 meter and 5 centimeter respectively, the mean of environmental gamma was obtained. The number of dosemetry in each season was at least 30 in the morning and in the afternoon. In each dosemetry, 3 points in the source of the dosemetry was repeated in the deposits. The dose meter in each height was kept on a stool for 10 minutes and it registered the information momentarily. The findings were analyzed through a T-test. Results: Results during one year study show total average level of dose of environmental radiation for Hot springs of Ghainarjeh 26.3, Ilando 21.6, and Moill 22.04 msv.y -1. Conclusion: Average dose of gamma rays in Hot springs is high in proportion to world standard which is more than 8-10 times and this region can be considered as high natural radioactive.
Seyed Hashem Sezavar , Maryam Valizadeh , Mazyar Moradi , Mohammad Hosein Rahbar,
Volume 10, Issue 1 (spring 2010)
Abstract
Background & Objectives : In spite of effective advances in diagnosis and management, ST Elevation Myocardial Infarction (STEMI) is a major health problem in industrialized world and an increasingly important problem in developing countries. Considering the role of age and gender in Myocardial Infarction (MI) and socioeconomic and cultural changes in Iran in recent decades which can affect the epidemiology of the disease, we aimed to determine trend of changes in age and gender of patients with first STEMI in recent decade. Methods :This observational cross-sectional study was based on completing check lists for patients with first STEMI in Rasul-e-Akram Hospital from 1998 to 2007. The Data were analyzed with ANOVA, chi2 and Mann-Whitney tests at = 0.05 using SPSS 14. Results :Out of 1829 patients with first STEMI, 76.4% were men and 23.6% women who had mean age of 59.09 ± 12.7 years totally. The mean age of men (56.9 ± 12.2 years) was significantly lower than women (66.1 ± 11.6 years) (p < 0.001) . Trend of change in mean age for men, women and overall had no specific patterns of change in 10 years. Premature MI occurred in 15% of patients without any particular change during study period. No statistically significant change in proportions of gender and risk factors was seen in a period of 10 years. The most common risk factors were smoking (43.7%) and hypertension (32.8%) respectively. 23 . 7% of patients had hyperlipidemia and 18.8% were diabetics. Conclusion: Trend of changes in age and gender of mentioned patients had no significant change over 10 years which can indicate main role of biologic factors. Although this was an observational study unchanged major risk factors in a decade may mark out inadequate primary prevention.
Mahin Kamali Fard, Raziyeh Alizadeh , Fahimeh Sehati Shafaei , Mortaza Gojazadeh,
Volume 10, Issue 1 (spring 2010)
Abstract
Background & Objectives :Prematurity is still one of the main causes of neonatal mortality and morbidity that makes a lot of financial, psychosocial and emotional problems. Although the main cause of preterm labor is unknown but understanding of its risk factors is important for planning health policies for preventing and decreasing the rate of preterm labor. This study aimed to compare lifestyle of women with term and preterm delivery. Methods :This research is a case-control study. Subjects of this study were 132 women with preterm labor and 264 women with term labor that referred to Educational and Medical Center of Alzzahra. The subjects were selected by convenience method and matched in age and educational level. Data were collected by questionnaire containing two sections, demographic characteristics and woman's lifestyle including,nutrition, exercise, smoking and use of alcohol and substance abuse, social support, stress management and self care. Data were analyzed by SPSS with descriptive statistics and statistical tests of t Test, Man Witny U, χ 2 and Fisher's Exact Test. Results : The results of this study showed significant differences in nutrition, smoking, use of alcohol, substance abuse, social support, stress management and self care between two groups, but the mean score of exercise in term and preterm birth was not statistically significant. Conclusion: The findings of our study suggest that there is a relation between lifestyle in pregnancy and preterm birth. Lifestyle is changeable and achieving this aim is possible by efforts to increase health education .
Shaban Alizadeh , Shahab Bohlooli , Ali Abedi , Seiyed Hadi Mousavi , Behzad Jafazadeh, Norooz Hamrang , Ali Imani,
Volume 10, Issue 4 (winter 2010)
Abstract
Background & Objectives: Leptin is a hormone secreted from adipocyte tissue with established role in the differentiation and proliferation of hematopoietic cells. This hormone has major impact on fat metabolism. LIF is a pleiotropic cytokine with extensive hematopoietic, neuronal, and endocrine actions. LIF and IL-6 are leading to decreased level of leptin by activating signaling via their own receptors. Body mass index (BMI) has a direct connection with the leptin. It seems that Hb and HCT levels are also implicated in disease prognosis. This study was conducted to evaluate leptin, LIF and IL-6 serum levels and also to measure the amounts of BMI, Hb and HCT in lymphoid leukemia patients . Methods: The study was carried out on 30 leukemia patients (15 cases ALL and 15 cases CLL). Fifteen healthy subjects were considered as control. Serum levels of leptin, LIF and IL-6 were measured by ELISA. BMI was calculated by statistical formula. The amount of Hb and HCT were measured by cell counter. Data was analyzed by SPSS software. Statistical differences between groups were assessed by t test, and p<0.05 was considered significant. Results: Leptin serum level showed a decrease in ALL patients (p<0.002), but there was an increase in CLL patients when comparing with control group (p<0.003). BMI and serum levels of leptin, LIF and IL-6 were showed a significant decrease in ALL patients in comparison with control group (p<0.05). Although, LIF serum levels and BMI in CLL patients showed a decrease, a significant increase in leptin serum level was observed (p<0.05). A decrease in IL-6 level was also observed which was not significant. The relation between BMI and leptin serum level in ALL and CLL patients were not significant, nevertheless it was significant in control group (p<0.05). Hb and HCT levels in both ALL and CLL patients showed a significant decrease (p <0.05). Conclusion: Findings on serum levels of LIF, IL-6, Leptin, Hb and HCT and also its relations with BMI in ALL and CLL patients suggest that, these factors may have important role in physiopathology of lymphoid leukemia.
Sadegh Hazrati , Seiyedhosein Sabery , Hadi Peeridogaheh , Roghaiyeh Alizadeh , Hadi Sadeghi,
Volume 12, Issue 1 (spring 2012)
Abstract
Background & Objectives: Different factors increase risk of disease transmission in women's barbershop and disinfection of instruments, as a major preventive measure, plays an important role in the control of disease transmission . Therefore, present study was conducted to investigate the quality of barber tools disinfection in women salons in Ardabil in 2009. Methods : In a cross-sectional study , 96 women salons were randomly selected. Data were compiled using a questionnaire, observation, and recording results of microbial cultures from barbering tools and analyzed using χ 2 and descriptive statistics. Results : Personal shaving kits were being used only in 5.2% of barbershops and 56 % of barbers applied Micro 10 as a disinfectant of barbershop tools. 64.6 % of samples were microbiologically positive and Staphylococcus aureus was detected in 53 % of positive samples. Positive results were significantly higher in barbershops that did not follow standard procedure of tools disinfection ( p<0.0001). Conclusion: As a result of our study we suggest the following points to improve population health in the barbershops : training on proper disinfection techniques, promotion of Micro10 application and avoid of unhealthy behaviors in barbershops.
Roya Motavalli, Leila Alizadeh, Maryam Namadi Vosoughi, Samira Shahbazzadegan,
Volume 12, Issue 4 (winter 2012)
Abstract
Background & Objectives: Induced and unhealthy abortion is common condition in the worldwide, particularly in developing countries as Iran which accompanies with maternal mortality and morbidity. The aim of this study was to obtain the prevalence, risk factors and complications of induced abortion. Methods : A retrospective study was conducted in 1200 women, who referred to health centers of Ardabil. The eligible participants were included by random sampling. We used a prepared questionnaire with questions on demographic characteristics, pregnancy history and contraception methods. To determine the validity and reliability of questionnaire the content validity and re-test methods were used respectively. Statistical analyses were performed with SPSS software (pakage 16) using t-test and chi-square. Results: The prevalence of induced abortion was 8.3%. The main reason was represented having desired number of children. Other reasons were economic hardship situation, low pregnancy interval, undesirable fetus gender, parents age, academic education and occupation of mother and increased duration of being married (p<0.0001). The complication of induced abortion were vaginal bleeding (70/5%), bleeding and infection (7/4%), and hospitalization (49/5%). Conclusion: According to the results of this research it is expected that authorities and health personnel detect the high risk group of society and present necessary education and individual consultations to more awareness and change their attitude and beliefs on acute complication resulted from induced abortion.
Najmaddin Saki, Akbar Dorgalaleh , Zahra Kashani Khatib, Shaban Alizadeh , Fakher Rahim, Hamid Galehdari, Bijan Kaikhaei, Mohammad Pedram , Ali Dehghani Fard ,
Volume 13, Issue 3 (autumn 2013)
Abstract
Background: Co-inheritance of hemoglobin gene defects is a rare important status that can lead to double heterozygote or homozygote with significant clinical manifestations. Such conditions can be observed in co-inheritance of alpha-thalassemia with beta-thalassemia or hemoglobinopathy. The aim of this study was to evaluate the prevalence of alpha-thalassemia with beta-thalassemia and hemoglobinopathy co-inheritance in a considerable number of Iranian. Methods: This descriptive study was performed on patients with abnormal hematological findings in favor of alpha-thalassemia, beta-thalassemia or beta-hemoglobinopathies. Patients with low MCV and MCH levels and high HbA2 (>3.5) and those with low MCV and MCH and normal or low HbA2 were candidate for molecular analysis for beta and alpha thalassemia respectively. Abnormal Hb electrophoresis was diagnostic criteria for molecular analysis of beta-hemoglobinopathies. Results: Study revealed that more than half of the patients with alpha-thalassemia affected simultaneously by beta-thalassemia and about thirty percent inherited beta-hemoglobinopathies. Among patients with beta-thalassemia, HbSCd6 (A-T) was the most common mutation and in alpha-thalassemic patients α 3.7 was the commonest mutation. Conclusion: Relatively high prevalence of co-inheritance of alfa-thalassemia with beta-thalassemia and hemoglobinopathies reflect the necessity of genetic consulting and molecular analysis in diagnosis of such conditions.
Mohsen Yaghoubi , Lotfali Bolboli , Abbas Naghizadeh , Aydin Valizadeh , Samad Safarzadeh ,
Volume 14, Issue 1 (spring 2014)
Abstract
Background and Objectives : The risk of coronary artery disease increases with increasing of blood pressureboth in hypertensive and normotensive persons on the other hand nutritional factors have asignificant effect on blood pressure. The purpose of this study was to assess theeffect of caffeine on blood pressure in sedentary healthy male during resistance exercise. Methods: In single-blind crossover study , twenty healthy and non-athlete male in the University of Mohaghegh Ardabili randomly selected and stratified according to age and BMI into twogroups: caffeine and placebo. The subjects performed repetitions to exhaustion at 60% of 1RM for any motion of chest press, leg press, squat and lat pulldown, 1 hour after taking caffeine (6 mg/kg body weight) or Placebo (similar dosage of starch). Blood pressure (BP) was measured before and 1 hour after taking caffeine and also immediately after any exercise. Data analysis was conducted using independent and paired t-test. Results : Results indicated that systolic and diastolic BP and mean arterial pressure significantly elevated following caffeine intake at rest, but no significant differences were observed after exercise. Conclusion: These findings indicate that caffeine at this dosage level alters cardiovascular dynamics by augmenting arterial blood pressure in moderately non-athletes male at rest. However, it seems that taking caffeine before resistance exercise does not cause abnormal elevations in blood pressure in sedentary healthy male.
Rana Alizadeh Hajikhajehlu , ,
Volume 17, Issue 1 (spring 2017)
Abstract
Background & Objectives: Infertility (abortion & stillbirth) is one of the most common medical problems during pregnancy. Approximately 10-15% of all clinically recognized pregnancies are lost before the birth. Pregnancy loss is a multifactorial phenomenon. This study was an attempt to analysis the cytogenetic abnormalities of the parents with frequent spontaneous abortion and stillbirth.
Methods: In this study, the samples were analyzed by GTG-banding technique.
Results: From a total of 200 reviewed blood samples, 188 persons (94%) had natural karyotype and 12 persons (6%) had chromosomal abnormalities. Chromosomal aberrations were found in 5 (2.5%) females and 7 (3.5%) males. The prevalence of chromosomal abnormalities was as follows: 5(41.6%) pericentric inversion of chromosome 9, 3 (25%) polymorphism 15p+, 1(8.3%) translocation, 1 (8.3%) polymorphism 15ps+, 1 (8.3%) polymorphism 1qh+ and 1 (8.3%) unknown chromophil band on the short arm of chromosome 21.
Conclusion: Chromosomal analysis is an important etiological investigation in couples with recurrent spontaneous abortions and stillbirth, and genetic counseling helps to make a correct decision on further options of reproduction.
Mahmoud Mahami-Oskouei , Mehdi Mohebali, Adel Spotin, Zahra Alizadeh,
Volume 18, Issue 3 (autumn 2018)
Abstract
Leishmania parasites as the causative agent of leishmaniasis belong to Trypanosomatidae family. Parasite, vector, vertebrate host and environment are major factors in pathogenesis of Leishmania.
Parasite dependent factors are virulence factors which exist in Leishmania species such as LPG, GP63. In recent years, the importance of these factors in the field of vaccine and drug has been considered by researchers. Sand fly biting behavior and salivary gland proteins are vector dependent factors which are effective in the Leishmania pathogenesis. Age, gender, nutrition, immune system, infectious diseases, genetic, occupation, socio-economic characteristics, and habitat are vertebrate host mediated factors. Temperature, rainfall, wind and its speed, soil, and continuous changes in climate are also environmental factors. Therefore the aim of this study was to evaluate the pathogenesis of Leishmania parasites.
Keyvan Anoush, Haleh Valizadeh Haghi , Hamed Vahedi, Rahman Nemati, Hesam Mikaeeli Khyiavi ,
Volume 18, Issue 4 (winter 2018)
Abstract
Background & objectives: Ectopic eruption is a disorder in which the tooth does not follow its usual course and if not diagnosed in a timely manner, leads to occlusal problems. The aim of this study was to determine the frequency of ectopic eruption of the first permanent molar and canine in patients referred to Ardabil dental school.
Methods: By observing the panoramic radiographs, recorded from 2016 to 2017, the frequency of ectopic eruption of first permanent molars in children aged 5 to 8 years and permanent canine in children aged 10 to 13 years was determined. The frequency distribution based on sex, involved jaw, unilaterality and bilaterality were evaluated using Chi-Square test.
Results: the frequency of ectopic eruption of the first permanent molar and permanent canine was 2.1% and 6.4% respectively. There was no significant difference in the frequency of ectopic eruption of the first molar, based on the patient's gender (p=0.366), jaw (p=0.132), and unilateral or bilateral involvement (p=0.366).Also, there was no significant difference between the frequency of ectopic eruption of permanent canine and the patient's gender (p=0.384), unilateral or bilateral involvement (p=0.056). The ectopic eruption of the permanent canine in the maxilla was greater than the mandible (p=0.012).
Conclusions: In this study, the frequency values of ectopic eruption were 2.1% and 6.4% for the first permanent molar and permanent canine respectively that were in the range of other studies reported from other populations.
َasieh Alizadeh Makvandi , Mohsen Khalili, Mehrdad Roghani, Sara Amiri Moghaddam ,
Volume 19, Issue 4 (winter 2019)
Abstract
Background & objectives: Depression is a common and debilitating brain disorder and a type of psychiatric syndromes. The most common symptoms of this disease are irritability, worthlessness, sleep problems and anxiety disorders. Reserpine is a drug that can cause depression in animals if used at a very low dose. Electroconvulsive therapy (ECT) is one of the most effective non-pharmacological treatments for depression. In this study, the effect of electroconvulsive therapy on male rats depressed by reserpine in behavioral tests and neural counting in the hippocampus and prefrontal cortex areas was investigated.
Methods: In this experimental study, 40 male rats were used and they were divided into four groups of ten: 1-control group, 2- ECT group, 3- Depressed group induced by reserpine (0.2 mg/kg i.p.), 4- Depressed + ECT group. Open field, sucrose preference, forced swimming and elevated plus maze tests were used to evaluate anxiety and depression-related behavioral function. At the end of the tests, histochemical studies were performed with neuronal counting in the hippocampus and prefrontal cortex.
Results: The results of anxiety and depression behavioral tests showed a significant difference between depressed group and depressed+ECT group (p<0.05). Similarly, studies of the tissue degeneration from hippocampal and prefrontal incisions, showed that ECT could significantly decrease cell death in the depressed+ECT group compared to the depressed group (p<0.05).
Conclusion: According to the results, ECT can reduce the anxiety and depression behaviors induced by reserpine injections in depressed animals and can cause neurogenesis in the hippocampus and prefrontal cortex.
Ali Alizadeh, Hamid Kayalha, Zohreh Yazdi, Aidin Binazadeh, Shahram Rastak, Mohammad Sofiabadi,
Volume 20, Issue 1 (spring 2020)
Abstract
Background & objectives: The use of controlled hypotension is important to reduce bleeding in some surgeries. This study aimed to determine the effects of dexmedetomidine (DEX) and labetalol for induced hypotension in maxillofacial fractures surgery.
Methods: In this triple-blind randomized controlled clinical trial study, the patients with maxillofacial fractures were randomly divided into two groups: group 1. Dexmedetomidine (DEX) (bolus dose: 1μg/kg and maintenance dose: 0.3-0.5 μg/kg/h) and group 2. Labetalol (bolus dose: 0.3mg/kg and maintenance dose: 0.2-0.5 mg/kg/h). The patient's hemodynamic indices (including heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were recorded at various surgical intervals. Finally, the surgeon's satisfaction (from 1-6 points) was evaluated. Data were analyzed using SPSS 19 software.
Results: The MAP, SBP, and DBP were significantly higher in the DEX group than the Labetalol group especially at 30 and 90 minutes after the bolus. The mean HR was significantly lower in the DEX group than Labetalol during the recovery period. The surgeon's satisfaction in the Labetalol group was significantly higher than the DEX group.
Conclusion: Based on the results, labetalol offers a better hemodynamics conditions than DEX during surgery and also lead to greater overall surgeon satisfaction.
Mehdi Valizadeh , Esmaeil Babaei, Rasoul Sharifi, Abbas Yazdanbod,
Volume 20, Issue 2 (summer 2020)
Abstract
Background & objectives: Colon cancer is a common disease in the world that causes high mortality in affected people. The lack of appropriate diagnostic and prognostic markers has led to the failure in early diagnosis of colorectal malignancies. MicroRNAs play an important role in controlling the expression of target genes involved in the development and progression of colon cancer. The aim of the present study was the bioinformatics identification of microRNAs with distinct expression in cancerous and non-cancerous colon samples.
Methods: This type of study was theoretical bioinformatics and microarray data of 1513 colon cancer samples with the accession number of GSE115513 were obtained from the GEO site and marker genes were selected by using R program. Target genes of the identified microRNAs were provided by TARGETSCAN software and finally, the graphical network was plotted in Cytoscape software.
Results: Analysis of microarray data showed that has-miR-663b, has-miR-650, has-miR-17-5p, has-miR-4539 and has-miR-501-3p have biomarker potential in cancer samples. Statistical analysis and investigation of the target genes indicated that miR-663b (ROCAUC=0.8965, p=0.001) and has-miR-650 (ROCAUC=0.9104, p=0.001) had significant distinct expression between cancerous and non-tumor margins with biomarker potential.
Conclusion: The has-miR-663b and has-miR-650 genes can be used as diagnostic markers to distinguish colon cancer from non-cancerous samples
Afrouz Mardi, Golnaz Alizadeh,
Volume 22, Issue 1 (Spring 2022)
Abstract
Background & objectives: Urinary tract infection is still one of the most common diseases that affect pregnant women. The aim of this study was to determine the impact of sexual hygiene behaviors on urinary tract infection in pregnant women.
Methods: A case-control study was conducted on 100 pregnant women with urinary tract infection (case group) and 150 pregnant women without urinary tract infection (control group) in health centers of Ardabil city in 2020. Purposive sampling was done in 6-10 weeks of pregnancy. The information was collected through a researcher-made questionnaire. SPSS 21 software was used for statistical analysis of data. The odds ratio (OR) of infection in both groups was estimated by logistic regression.
Results: Sexual health behaviors in the majority of women of the case group (47%) were average (with score of 50.1-66), but in the majority of the control group (49.33%) were good (with score of 66.1-84) (p<0.001). Sexual intercourse 3 or more times in a week in the last 30 days was significantly higher in the case group than in the control group (p=0.001). Spouse bathing before sexual intercourse was less in women in the case group than the control group (p=0.022). Statistically significant differences were observed in Pre-coital voiding (p=0.04), Post coital voiding (p=0.02) and post-coital bathing (p=0.03) in the two groups.
Conclusion: Sexual hygiene behaviors play an important role in preventing or contracting urinary tract infections. Therefore, training and improving hygiene behaviors in women and their spouses is an effective step in reducing urinary tract infections.
Zahra Alizadeh, Hafez Mirzanejad Asl, Behnam Mohammadi Ghalebin, Zahra Heidari,
Volume 22, Issue 3 (Autumn 2022)
Abstract
Background & objectives: Fishes are one of the most important sources of zoonotic parasites throughout the world. This study aimed to determine helminthic parasites of Fish caught in the Aras River.
Methods: During 2020-2021, a number of 100 fishes including 20 Cyprinus carpio, 10 Hypophthalmichthys molitrix, 5 Hypophthalmichthys nobilis, 12 Silurus glanis, 5 Aspius aspius, 15 Ratilus rutilus, 3 Sander lucioperca, 22 Luciobarbus capito, and 8 Abramis brama were caught. All parts of the fish body (scales, gills, eyes, muscles, gastrointestinal tract) were examined for Helminthes parasites. After clearing and temporarily staining with Lactophenol-Azokarmin, morphological characters of worms were analyzed using a calibrated microscope equipped with a camera.
Results: After examining and evaluating the samples, 18 (18%) of the fish were infected with at least with one helminthic parasite. The species and percent of infection were as follows: Ligula intestinalis plerocercoid: Cyprinus carpio 40%, Ratilus rutilus 13.33%, Abramis brama 12.5% in the abdominal cavity. Bothriocephalus sp.: Cyprinus carpio 5% in the intestine. Diplozoon sp.: Cyprinus carpio 5% and Ratilus rutilus each 6.7% in gills. Dactylogyrus sp.: Cyprinus carpio 10%, Abramis brama 12.5% in gills. Clinostomum sp. metacercariae: Cyprinus carpio 5% infected with metacercaria in gills and abdominal cavity.
Conclusion: Among the investigated types of fish, the highest level of infection with helminthic parasites was found in common carp. Also, among the helminthic parasites found, the highest frequency is related to Ligula intestinalis, followed by Dactylogyrus
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