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Showing 4 results for Ahmadpour
Morteza Bonyadi , Saba Ahmadpournazm, Simin Taghavi, Farzam Ajamian ,
Volume 16, Issue 1 (spring 2016)
Abstract
Background & objectives: Recurrent miscarriage (RM) occurs in 1–3% of couples attempting to bear children. Thrombophilia is one of the suspected causes of recurrent miscarriage. The factor XIII makes the clot stable at the end of coagulation cascade. The polymorphism G103T of factor XIII gene is the most common polymorphism that affects F XIII activity. We aimed to study the possible association of FXIII gene polymorphism (V34L) with recurrent miscarriage among patients in Northwest of Iran.
Methods: The study groups consisted of 70 patients with two or more consecutive miscarriages. The control group included 50 women with at least two successful deliveries and no history of pregnancy loss. DNA from both groups analyzed for carrying mutation of FXIII by PCR-RFLP. The test used for statistical analyze.
Results: Two patients (%2.85) in the case group were homozygote (TT) for 34 Leu mutation whereas no homozygote (TT) was found in control group (p>0.05). 19 patients (%27.1) in the case group and 13 women (%26) in the control group were found to be heterozygote for G103T polymorphism (p>0.05). No significant difference was observed between patients with RPL and healthy women for G103T mutation.
Conclusion: No statistically difference was observed between case and control group.
Ensieh Ahmadpour, Maghsoud Piri, Mohammad Ali Azarbijani,
Volume 21, Issue 4 (winter 2022)
Abstract
Background & objective: Alzheimer's disease (AD) is the most common cause of dementia among the elderly, threatening their quality of life. On the other hand, regular exercise is associated with improved brain health and cognitive function. However, the mechanisms of these benefits have not yet been fully elucidated. Therefore, the aim of this study was to investigate the effect of 4 weeks of moderate intensity interval aerobic training on cognitive function and expression level of PGC1α and VEGF genes in the hippocampus of old rats with AD.
Methods: For this purpose, 20-month-old male Wistar rats were divided into three groups of AD (n=8), AD+exercise training (n=8) and control (n=8). Intra-hippocampal injection of Aβ42 was used to induce AD. The animals in the exercise group performed moderate-intensity interval aerobic exercise for 4 weeks, 5 days a week. To assess spatial learning and memory, the animals underwent the Morris water maze test 48 hours following the last training session. Then, the animals were killed and hippocampal tissue was extracted. Real time-PCR method was used to measure gene expression. Statistical analysis was performed using one-way analysis of variance and Pearson correlation coefficient at the significance level of p£0.05.
Results: The results showed that Aβ42 injection impaired spatial learning and memory function and reduced the expression level of PGC1α and VEGF genes in hippocampal tissue (p£0.05). Aerobic exercise improved spatial learning and memory function and increased PGC1α and VEGF genes expression (p£0.01). Also, a significant positive relationship was observed between the PGC1α and VEGF gene expression levels in the hippocampus (r= 0.859, p≤0.01). In addition, there was a significant inverse relationship between PGC1α and VEGF genes expression and the mean time spent to find the platform (r= -0.9, p£0.01 and r= -0.750, p£0.01, respectively), and a significant positive relationship with the time spent in the target quadrant (r= -0.794, p£0.01 and r= -0.632, p£0.01, respectively).
Conclusion: In general, aerobic training improves spatial learning and memory performance in old animals with AD; up-regulation of the exercise-induced PGC1α/VEGF pathway in the brain, at least in part, appears to be involved in this adaptation.
Reza Ahmadpour, Somayeh Hekmatfar,
Volume 23, Issue 2 (summer 2023)
Abstract
Background & objectives: Dental anxiety is an effective factor in reducing children's dental visits. It is necessary to identify the factors involved in causing dental anxiety to promote public health. The purpose of this study was to evaluate the relationship between dental fear and anxiety in 5-10 -year -old children with dental caries and a history of trauma in Ardabil dental clinics in 2022.
Methods: 247 children (139 girls and 108 boys) were examined in terms of demographic information, history of oral and dental trauma, and socio-economic status through a questionnaire. The dmft/DMFT index was determined using the clinical examination to check the oral health condition. Dental fear and anxiety were measured using two standard scales, FIS and CFSS-DS. Chi-square test was used for data analysis .
Results: According to the FIS index, the prevalence of dental anxiety was 11.4% and according to the CFSS-DS questionnaire, it was 18.2%. Children aged 5-7 years showed more anxiety (p=0.043). Children who had a dental visit showed higher levels of anxiety based on the CFSS-DS index (p=0.002). According to the FIS index, children without a dental visit history had a higher frequency in the "very upset" group (p=0.009). Severe dental caries in permanent teeth (DMFT) were associated with a higher level of anxiety (p=0.028). No statistically significant relationship was found between gender, number of siblings, child's position in the family, parent’s education, family income level, history of trauma and dmft with dental anxiety.
Conclusion: The results of the present study showed that age, history of dental visits and decay of permanent teeth are effective factors on children's dental anxiety.
Saba Ramezanzadeh, Golam Reza Barzegar, Hamid Oveisi Oskouei, Majid Pirestani, Mahmoud Mahami-Oskouei, Farzaneh Jafarian, Ehsan Ahmadpour, Seyed Abdollah Hosseini,
Volume 23, Issue 4 (Winter 2024)
Abstract
Background: Opportunistic pathogens such as Cryptosporidium, Isospora belli, Blastocystis, etc. cause various gastrointestinal and non-digestive diseases in people with HIV. These symptoms are especially severe in people with HIV who have a CD4 count of less than 200. This study aimed to determine the prevalence of parasitic infections in people living with HIV in Tabriz.
Methods: This cross-sectional and descriptive study was performed on137 people with HIV referred to Behavioral Disease Counseling Centers in Tabriz, 2019-2021. Then, after receiving written consent, fecal samples were collected and evaluated for the detection of parasitic infections using direct methods, Ziehl-Neelsen and Trichrome Weber stain.
Results: A total of 137 stool samples were collected, including 93 males and 44 females. Most of them were in the age range of 20-60 years. The overall frequency of parasitic infections was 57.7% and the highest prevalence was related to Blastocystis 24.1% and Cryptosporidium 14.6%.
Conclusion: Due to the relatively high prevalence of parasitic infections, especially Blastocystis and Cryptosporidium in people with HIV in Tabriz, which can endanger the health of these patients, essential interventions, including personal hygiene training to control and prevent infection with these pathogens, seem to be necessary.
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