Background & Objectives : Considering the widespread use of walnut in the cooking of foods and medical applications, the present study evaluate possible effects of alcoholic extract of Walnut on FSH, LH and testosterone concentration in adult male rats.

  Methods: In this experimental study 40 adult male Wistar rats weighing 250-300g were used and divided into five groups, eight rats per each group. Control group do not receive any treatment . Organic solvent was administered as placebo to sham group , three experimental group, that receive different doses of alcoholic extract of walnut , 10 - 20 and 50 (mg/ kg/Intraperitoneally) respectively, were fed daily and serum levels of FSH, LH and testosterone were measured. All data were analyzed by SPSS 16 and one way ANOVA test.
Results: In comparison with control group, only in group treated by 50 mg/kg of walnut extract, FSH and LH concentration increased significantly (P<0.05). Concentration of testosterone in experimental groups (20 mg/kg and 50mg/kg dose of extract) showed significant statistical difference compared with other groups (P<0.05) .

  Conclusion: According to results of this study, alcoholic extract of Walnut affect pituitary- testis axis and increase GnRH and LH secretion rate therefore enhance reproductive activity in male rats.

 Background & Objectives: Diabetes mellitus is recognized with severe metabolic complications. Many herbal medicines have been recommended for treatment of diabetes. In this study, the antidiabetic and analgesic effect of hexanic and alcohlic extract Trigonella-foenum graecum was investigated in normal and streptozotocin-induced diabetic rats.

 Methods: Present study was carried out in 2011 at Guilan University of Medical Sciences, 48 male Sprague Dawley rats (230-300 gr) were divided into six groups: control, type 1 diabetic, and 4 treat ed groups that received intraperitonealy hexanic and alcoholic extract of fenugreek (100, 200 mg/kg body weight) for 28 days. Two experimental models were used (acetic acid, and hot-plate tests) in order to characterize the analgesic effect. Blood glucose was measured with glucometer. Data analyzed with spss software 16 and one way ANOVA and Tukey tests. P<0.05 was statistically significant.

 Results: Compared to control rats, both of the aqueous - alcoholic and Hexan ic extract significantly reduced blood glucose level in all diabetics groups. This effect was stronger in groups that received Hexanic extract (p<0.05) . All groups received the aqueous - alcoholic and Hexan ic extract showed analgesic effect but this effect was more clear in the Hexanic 200 mg/kg group (p<0.05).

 Conclusion: Fenugreek extract possesses hypoglycemic , and analgesic effects .