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Showing 6 results for Type of Study: short communication
Nematollah Gheibi , Javad Shahbazi, Zahra Zarmohammadi , Mahmoud Alipoor Heydari , Eftekhar Kakaeie, Mohammad Sofiabadi ,
Volume 17, Issue 1 (4-2017)
Abstract
Background & objectives: Propolis is a natural product with powerful antioxidant and therapeutic effects. The aim of this study was to investigate the effect of propolis on passive avoidance memory in adult male mice.
Methods: In this study, 40 adult male mice were divided into 8 groups, including control, sham (solvent) and 3 treatment groups orally treated with 50, 100 and 200 mg/kg of propolis, respectively for two weeks before and one week after treatment. Then, passive avoidance learning and memory were recorded in timescales of 24 and 48 hours, 4 days and a week after shock by the shuttle box. Data were analyzed by ANOVA and Dunnett’s post hoc tests, and p<0.05 was considered significant.
Results: Administration of propolis (50 mg/kg) significantly increased the dark chamber entering time at intervals of 24 and 48 hours (p<0.001) and at concentrations of 100 and 200 mg/kg in all time periods after the shock (p<0.001).
Conclusion: Oral administrations of propolis can improve learning and memory dose-dependently in adult male mice.
Javad Rahmati, Zahra Farahani-Nik , Hojjat , Molaei-Govarchin-Qala ,
Volume 20, Issue 1 (4-2020)
Abstract
Introduction: Skin defect reconstruction following tumor resection, is a challenge for surgeons. Nose as a key point of aesthetics has a significant role in this scenario. One of the practical approaches is dorsal nasal flap (Rintala) to cover lower 1/3 nasal defects. The disadvantages of this method are limitation to reach lower areas, especially nose tip, flap ischemia and wound dehiscence.
Case report: A 47 years old man with supratip BCC lesion underwent tumor resection and prepared for dorsal nasal flap reconstructive surgery, in which dorsal hump resection caused relaxed flap transfer and ultimately more acceptable profile view.
Conclusion: Advancement of the dorsal nasal flap more distally can be achieved by dorsal hump reduction in selected patients, which makes patients more satisfied with their new nasal form and appearance and reduces the risk of distal flap ischemia.
Seyed Ali Bazghandi , Somayeh Safarirad, Mohsen Arzanlou, Hadi Peeri-Dogaheh , Hossein Ali-Mohammadi , Farzad Khademi,
Volume 20, Issue 2 (7-2020)
Abstract
Background & objectives: Bacterial antibiotic resistance is becoming a global health crisis. The aim of this descriptive, cross-sectional study was to investigate the prevalence of multidrug-resistant Pseudomonas aeruginosa strains in Ardabil.
Methods: During 9 months, between July 2019 and March 2020, 50 strains of Pseudomonas aeruginosa were collected from different clinical specimens in four hospitals of Ardabil and the prevalence of MDR, XDR and PDR strains of Pseudomonas aeruginosa were evaluated. Antibiotic susceptibility testing was assessed using the disk diffusion method.
Results: In the present study, the prevalence of MDR, XDR and PDR strains of Pseudomonas aeruginosa were 52%, 40% and 14%, respectively.
Conclusion: Due to high prevalence of multidrug-resistant strains of Pseudomonas aeruginosa in Ardabil, continuous monitoring of the antibiotic resistance trend in clinical isolates in order to select the best medication is necessary.
Bahman Ebrahimi-Torkamani , Marefat Siahkouhian, Ali Khazani, Anoshirvani Sajad, Bolboli Lotfali, Maryam Asadi,
Volume 20, Issue 3 (10-2020)
Abstract
Background & objectives: Over the last couple of decades, research has focused on attempting to understand the genetic influence on sports performance. Whole exome sequencing (WES) has great potential to explore all possible genetic variants associated with physical performance. However, this new technique has not been used in sports genetics research. Therefore the aim of this case study was to report new variants in genes involved in skeletal muscles strength (ACE, NOS3, IGF1R, IL-6) in an elite weightlifter using WES.
Methods: After obtaining a written testimony from a 32-year-old man, who is a member of the Iranian national weightlifting team, 5 cc of blood was taken and then DNA was extracted. DNA samples were analyzed using the whole exome sequencing method.
Results: Whole exome sequencing analysis revealed a missense variant (99454613G>A) in IGF1R, 22771156C>T polymorphism in IL-6, 150695726T>C and 150704250C>G polymorphisms in NOS3 and 61573761T>C and 61564052A>G in ACE genes.
Conclusion: Results of whole exome sequencing analysis revealed a missense variant and polymorphism in muscle strength and hypertrophy related genes in this elite weightlifter. However, other studies with larger sample sizes are needed to investigate the relationship between these variants and power athlete status.
Ramin Abiri, Samira Ghasemi, Malihe Bagheri Ghomi, Masoumeh Shahbazi, Ahmad Emami, Mahdi Mojarrab,
Volume 23, Issue 3 (10-2023)
Abstract
Background: Nosocomial infections are significant parts of the treatment challenges of hospitals. Different species of the Artemisia genus are widely distributed in Iran. The present study aimed to compare the in vitro effects of different aqueous extracts of Artemisia species against nosocomial bacterial strains.
Methods: 24 different aqueous extracts, including decoctions and infusions were prepared from the aerial parts of Artemisia ciniformis, A. turanica, A. kopetdaghensis, A. khorasanica, A. vulgaris, and A. sieberi. Total phenolic contents were determined by the Folin-Ciocalteu method. The minimum inhibitory concentration (MIC) values of the extracts against the bacterial strains including Staphylococcus aureus, Streptococcus pyogenes, Acinetobacter sp., Pseudomonas aeruginosa, Enterococcus faecalis, Staphyloccocus epidermidis, Micrococcus luteus, Klebsiella neumonia and Escherichia coli were measured using the microdilution broth method.
Results: The lowest MIC value was observed for the decoction of A. turanica (0.25 mg/ml) against S. pyogenes. The largest range of bacterial sensitivity (3 strains) was related to the decoction of A. sieberi. The growth of S. epidermidis was inhibited by a larger group of extracts. The highest total phenolic content was recorded for decoction and infusion of A. turanica.
Conclusion: The decoctions of the aerial parts of A. sieberi and A. turanica were superior to the other extracts in terms of the in vitro antibacterial spectrum and selective potency, respectively.
Ramin Abiri, Samira Ghasemi, Nastaran Sharei, Masumeh Shahbazi, Seyed Ahmad Emami, Mahdi Mojarrab,
Volume 24, Issue 1 (4-2024)
Abstract
Background: Nosocomial infections are considered as the important parts of the treatment challenges in hospitals. The genus Artemisia is widely distributed in Iran. Their species produce antibacterial, antiviral, and antifungal compounds belonging to different groups including phenols, terpenoids, sterols and polyacetylenes. The purpose of the present study is to investigate the in vitro effects of different hydroethanolic extracts of Artemisia species against bacterial strains in nosocomial infection.
Methods: 12 different extracts, including 50% and 70% hydroethanolic extracts were prepared from the aerial parts of Artemisia ciniformis, A. turanica, A. kopetdaghensis, A. khorasanica, A. vulgaris, and A. sieberi. The winterization of the extracts produced corresponding defatted extracts. The minimum inhibitory concentration (MIC) values of the extracts against the bacterial strains Staphylococcus aureus, Streptococcus pyogenes, Acinetobacter sp., Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococus epidermidis, Micrococcus luteus, Klebsiella pneumoniae and Escherichia coli were measured using the microdilution broth method. Total phenolic contents were determined by the Folin-Ciocalteu method.
Results: Among the extracts analyzed in this experiment, the lowest MIC value was observed for the 50% hydroethanolic extract of A. turanica (0.25 mg/ml) against S. epidermidis. The largest range of bacterial sensitivity (6 strains) was related to the 50% hydroethanolic extracts of A. turanica (defatted and non-defatted) and A. kopetdaghensis (defatted). The growth of S. epidermidis was inhibited by all of the extracts. The highest total phenolic content and yield of extraction were recorded for 70% hydroethanolic extract of A. sieberi and 50% hydroethanolic extract of A. ciniformis, respectively.
Conclusion: The 50% hydroethanolic extract of A. turanica was superior to the other extracts in terms of the in vitro antibacterial spectrum and selective potency. A. turanica and A. kopetdaghensis are probably suitable choices for further phytochemical and antibacterial investigations.
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