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Showing 7 results for Potassium

Daruoosh Savadi Oskoyi , Ali Abedi, Reza Khandaghi,
Volume 5, Issue 4 (12-2005)
Abstract

  Background & Objectives: Hypokalemic paralysis is a relatively uncommon syndrome which is potentially dangerous. If it is diagnosed and treated timely, the patients will be saved without any side effects. Various diseases can lead to this syndrome which is characterized with decreasing of serum potassium and acute systemic paralysis. In hypokalemic paralysis, the serum level of potassium reaches to less than 3.5 Mmol/lit. This may be caused by transferrence of K to intracellular department, (periodic hypokalemic paralysis and periodic thyrotoxic paralysis). The aim of this study was to determine sex and age prevalence of these patients as well as other features of the patients suffering from periodic hypokalemic paralysis.

  Methods: 55 patients participated in this prospective, descriptive and cross-sectional study which was conducted from 1999 to 2003. These patients were referred to the neurological department with hypokalemic diagnosis on the basis of laboratory and clinical examinations. The data were collected using a questionnaire. Also the serum level of K was measured. The data were analyzed by SPSS software.

  Results: from 50 patients, 46 (92%) were male and others were female. The patients were in 19-60 age range (Mean=33.16 SD=9.1). Mean serum level of K+ was 2.37 Mmol/lit (SD= 0.49) in the first hospitalization. The incidence of hypokalemia increased with aging , but majority of the patients (76%) were in age range 20-40. In 86% of the patients the time of hypokalemia crisis was at night and early morning. 11 patients had a high consumption of rich carbohydrate foods previously and 11 others had consumed corticosteroids. There was relapse of disease in 21 patients. 40 patients had paralysis in 4 extremities and 12 patients in 2 extremities. 4% of the patients were hypertensive and 4 patients were hyperthyroid. EKG was normal in 8 patients but in other cases there were abnormal changes.

  Conclusion: Despite the international references, the incidence ratio of male to female is high but the decreasing of K is more severe in female. Asetazolamide and oral KCL therapy not only decrease the period of hospitalization, but also are more effective in treatment of the disease.


Seyedreza Borzou, Mahmood Golyaf, Roya Amini, Mitra Zandiha, Bita Torckman,
Volume 8, Issue 3 (9-2008)
Abstract

Background & Objectives: hyperphosphatemia and hyperkalemia have major roles of mortality and morbidity in hemodialysis patients. In this study we evaluated the effectiveness of increase in blood flow rate on blood potassium and phosphate of hemodialysis patients.
Methods: This is a clinical trial study 42 patients were assessed during the hemodialysis. A questionnaire and laboratory tests were used for gathering data. At first questionnaire of demographic data was completed and then the weight of patients was connected to each session of dialysis. Then the patient was connected to dialysis machine and blood sample was gathered before dialyzer. After taking blood sample, flow rate was regulated on 200 ml/min in the first session and on 250 ml/min in the next session. During hemodialysis, hemodynamic status and clinical status of patients was controlled. At the end of hemodialysis and before disconnection patient from dialysis machine, a blood sample was taken from arterial set before dialyzer (4 blood samples for each patient). Blood sample was sent to laboratory and all of them were analyzed by one technician and with one set.
Results: Average phosphorus changed significantly from 3.35 to 2.94 with increasing Qb from 200 to 250 similar to the increase in Qb in potassium removal (from 3.43 to 3.52) meq/lit. Paired t-test (p0.005).
Conclusion: It can be concluded so that increase in blood flow rate from 200ml/min to 250ml/min, can affect removal phosphorus but can not affect removal of potassium

Moslem Abolhasanzadeh, Yousef Semnani,
Volume 9, Issue 1 (4-2009)
Abstract

  Background: Psychosis is a psychiatric disorder in which reality testing and interpersonal relationships in several important functional areas are impaired. Some biochemical disturbances occur during psychotic period. Due to the vital role of serum potassium level on psychotic patients and its effect on cardiovascular system, this study was conducted to investigate serum potassium changes.

  Materials and Methods: A prospective non- Randomized pre/post test study (Quasi-experimental) was conducted on 103 prepared samples obtained from 103 patients hospitalized in Imam Hossein and Taleghani Hospital during 2005-2006 in Tehran. All subjects were initially interviewed in the first day then considering inclusion / exclusion criteria, blood samples were drawn and Brief psychiatric Rating scales (BPRS) were completed by the researcher. The same process was repeated in the day before release. Data were analyzed through Spearman- multiple regression, Paired test, chi-square and Kolmogorov- Smirnov tests.

  Results: BPRS were significantly different in the first and last days of hospitalization (P<0.019) Serum Potassium levels of the first and last days were meaningfully different (P<0.005) there was a negative correlation between the severity of psychosis in the first day and serum potassium level.


Omeleila Rabiee, Ebrahim Alijanpor , Yousef Mortazavi,
Volume 9, Issue 1 (4-2009)
Abstract

  Backgroud & Objective : Inducing of safe airway and rapid , is very important in the anesthesia of emergency patients and it reduces many complications because of delay in the endotrachal intubation .In this group of patients, administration of succinylcholin is a choice. But, this drug has serious complication, that is sudden increase of serum potassium level , and could cause cardiac arrest .So ,it is suggested, use of non blocker dose of non depolarizant neuromuscular blocker (defasciculation), for reducing this response . So , the aim of this study , was to determine the effect of pretreatment atracurium on serum potassium level associated with administration of succinylcholine .

  Methods: This study was performed clinical trial on 82 elective patients aged between 15 -70 years whit ASAI-II (American society of anesthesiology of physical status class)who where scheduled undergo operate general surgery. Premedication drugs are used to all patients , according to weight. and first blood sample was taken, considered as control group. then pretreatment atracurium injection (50mcg/kg) and after three minutes, was performed induction with thiopental sodium (5mg/kg) and succinylcholine (1.5 mg/kg ), and after 5 minutes , second blood sample was taken, test group . blood samples, were poured in the espicial tube of serum potassium and immediately , serums were separated . Then , potasiom level of serums were measured with micro light . The datas analyzed with statistical program ( spss) and then , were compared .

  Results: According to the obtained results , the mean of serum potassium level after administration of succinylcholine associated with defasciculation atracurium and before the administration of pretreatment atracurium (base level) was not different . It was not seen , a statistically significant difference between two groups, with attention to paired- t-test(p=0.936) and wilcoxon signed ranks test (p=0.594).

  Conclusion: Regarding the results of this study , administration of pretreatment atracurium is not effective in prevention of hyperkalemia induced by succinylcholin with attention base level.


Neda Kiani Mavi , Marefat Siahkuhian, Kazem Hashemi Majd,
Volume 10, Issue 1 (4-2010)
Abstract

  Background & Objectives :Heart rate deflection point (HRDP) plays an important role in predicting anaerobic threshold and monitoring athletes training schedule. Despite some research, the physiological mechanisms involved in occurrence of the HRDP remains to be fully elucidated. The objective of this study was to survey of the agreement between Heart Rate Deflection Point (HRDP) and the Potassium Turn Point (KTP) in young athlete men.

  Methods :Thirty young men athlete volunteer (Mean ± SD age= 20 ± 1.21 years height = 176 ± 7.34 Cm and weight = 6.58 ± 5.66 Kg) were selected as subjects. Hofmann protocol was used to cause the HRDP. One week later and after determining the HRDP by using the S.Dmax method, subjects performed Hofmann protocol again and blood samples were taken from left forearm vein in five phases, simultaneously. The amount of potassium was measured directly by the Flamephotometer.

  Results :According to the results of study, the HRDP and KTP were occurred in average in 78% HRmax and 79% HRmax, in all of the subjects, also there was a highly agreement between HRDP and KTP (158 3.84 vs. 159 3.88 b/min). HRDP & KTP were occurred in third phase, simultaneously.

  Conclusion: Based on these results, exercise induced increase in serum potassium during Hofmann incremental cycle ergo-meter testing protocol can be one of the mechanisms of the occurrence of HRDP.


Homayoun Ebrahimian, Seyied Mohammad Firoozabadi, Mahyar Janahmadi, Mehri Kaviani Moghadam,
Volume 13, Issue 2 (6-2013)
Abstract

  Background & Objectives: The development of technology has naturally given rise to an increase in environmental low-frequency electromagnetic fields and consequently has attracted scholars' attention. Most of the studies have focused on transmission lines and power system distribution with 50 Hz. This research is an attempt to show the effect of 50 Hz magnetic fields on bioelectric parameters and indicates the possible influence of this change in F1 cells of Helix aspersa .

  Methods: The present research used Helix aspersa neuron F1 to identify the location of magnetic fields as well as the rate of effects of environmental magnetic fields on nervous system. Control group was used to study the effect of elapsed time, electrode entering and the cell membrane rupture. Intuition group and environmental group were considered in order to study the potential impact of interfering environmental factors and identify the effectiveness rate of magnetic fields, respectively. For the purpose of producing uniform magnetic field Helmholtz coil was used. Electrophysiological recording was realized under the requirements of current clamp. And, in order to show the impacts from magnetic fields on ion channels Hodgkin-Huxley cell model was applied. All data were analyzed taking the advantage of SPSS 16 software and two-way ANOVA statistical test. P < 0.05 was considered as significance level. And MATLAB software environment and PSO were used in order for applying the algorithm and estimating the parameters.

  Result: No statistically significant difference was found between control and sham groups in different time intervals. Once the 45.87 microtesla was applied significant differences were observed 12 minutes after the application. The highest amount of change happened 14 minutes after the application of more fields. With the application of the field, the amplitude of the sodium action potential shows decreasing trend . No significant changes were observed in different time intervals, whereas significant differences were seen in frequency of action potential during different time intervals. The amplitude of AHP shows no significant changes .

  Conclusion: The results indicated that low-frequency magnetic fields with 50 Hz frequency will directly lead to change in bioelectric activities of neurons through a change in amount and rate of opening and closing of ionic channels and the conductivity of sodium and potassium channels reduces together with increase in conductance of potassium dependent calcium channel (AHP).


Behnood Abbasi , Masoud Kimiagar, Shahriyar Shahidi , Minoo Shirazi, Khosro Sadeghniiat, Mahdi Hedayati , Bahram Rashidkhani,
Volume 13, Issue 2 (6-2013)
Abstract

  Background & Objective: Advances in public health and control of infectious diseases have led to increased number of elderly people in the world including Iran. Thus serious concerns exist in terms of age-related diseases . Consequently, Iran’s ministry of health has chosen “ageing and health” as the theme for 2012 along with WHO. Psychological disordersare among the most prevalent diseases in elderly people. Recent studies suggest a two-way relationship between some psychological disorders and insomnia. Also there is evidence implying magnesium role in improvement of aforementioned disorders. The objective of this study was to determine the effects of dietary magnesium supplementation on mental health in insomniac elderly subjects.

  Methods: A double-blind randomized clinical trial was conducted on 46 insomniac elderly subjects randomly allocated into the magnesium or the placebo group, receiving daily for 8 weeks either 500 mg magnesium or a placebo, respectively. SCL-90-R and ISI questionnaires were conducted at baseline and at the end of the intervention period. Serum magnesium and cortisol levels were also determined in the patients. In addition, information was obtained on anthropometric confounding factors and daily intake of magnesium, calcium, potassium and caffeine using 24-hr dietary recall questionnaire for 3 days. The N4 and SPSS19 were used for data analysis.

  Results: No significant differences were observed in assessed variables between the two groups at baseline. As compared to the placebo group, in the experimental group, dietary magnesium supplementation brought about statistically significant decreases in GSI, PST, PSDI, ISI scores as well as somatization , anxiety, psychoticism , and depression symptoms and serum cortisol concentration. While the obsessive-compulsive , interpersonal sensitivity, hostility , phobic anxiety, paranoid ideation scores and serum magnesium concentration were not different between the experimental and the placebo groups.

  Conclusion: In this study dietary magnesium supplementation resulted in improvements in insomnia severity index and some indices of mental health.



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