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Showing 4 results for Probiotic Bacteria

Nader Pashapour, Mohamaad Hosein Hosseinianzakaria,
Volume 5, Issue 1 (4-2005)

 Background & Objectives: Yogurt is recommended as a treatment for acute diarrhea. This study was conducted to determine the effect of pasteurized yogurt consumption on acute non-bloody and non-mucoid diarrhea in hospitalized 6-24 month old infants as compared with that of routine treatment.

 Methods: In a clinical trial study 80 children with 6 to 24 months of age with diarrhea for less than four days and were hospitalized in Urmia Imam Hospital, were assigned into two groups. The first group consumed yogurt containing streptococcus thermophilus and lactobacillus bullgaris 5 ml/kg per day while the second group received the routine treatment. Those suffering from malnutrition, bloody stool and diarrhea without GI source were excluded. Reduction of diarrhea frequency to half compared to admission time was regarded as response to treatment. Weight gaining, duration of admission and reduction of diarrhea frequency were compared in two groups.

 Results: The two groups were not significantly different in terms of age, weight and frequency of diarrhea at the time of admission. Mean hospitalization days, weight gaining, reduction of diarrhea frequency were 2.7±0.91 days, 435± 89.30 grams, and 4.30±1.74 times respectively for case group and, 3.1± 0.74 days, 383 ± 98.96 grams, and 3.60±1.23 times for control group respectively. No significant differences were observed between two groups regarding mean hospitalization days (P=0.035), reduction of diarrhea frequency (P=0.049) and weight gain (P= 0.017).

 Conclusion: Consuming pasteurized yogurt as a probiotic agent has a positive effect in treatment of acute nonbloody and nonmucoid diarrhea. Public use of yogurt is recommended.

Hamid Mirzaei , Soltanali Mahboob , Karim Kazeman Alanag , Gity Karim ,
Volume 6, Issue 4 (12-2006)

  Background & Objectives: Salmonella is amongst the most important food-borne pathogens and s .typhimurium is the most common species causing food infection. L. casei, B. bifidum and B. angulatum are among probiotics with siginificant benefical effects in consumers. The purpose of this study was to investigate the interaction of the mentioned probiotics with s .typhimurium in vitro and growth in synthetic peptone water medium to evaluate the provisional effects of probiotic consumption in prevention and treatment of s .typhimurium food infection in humans.

  Methods: In order to activate the lyophilized bacteria, they were inoculated in erlene meyer containing peptone water and incubated at 37 °C for 24 hours. The activated probiotics and s .typhimurium were then incubated separately and together in peptone water medium for 24 hours at 37 ° c. Then, the number of their probiotic bacteria and S.typhimurium were counted in MRS and BGA media using surface plate method. This procedure was repeated 10 times for each experiment and a mean number of s .typhimurium in each ml of erlene meyer containing s .typhimurium alone and with probiotics and also the mean number of probiotic bacteria in each ml of erlene meyer containing probiotic alone and with salmonella were compared using independent t-test.

  Results: Co-cultural growth of L.casei and B.angulatum significantly inhibits s .typhimurium growth (P<0.05) but the inhibitory effect of B.bifidum was not meaningful and the co-culture of S.typhimurium had no meaningful effect on the growth of the above bacteria.

  Conclusions: Consumption of products containing L.casei and B.angulatum could have benefical effects in prevention and treatment of S.typhimurium infection although more in vivo researches should be carried out in this regard.

Jalal Solati, Azar Sabokbar, Jalil Vand Yousefi , Nasrin Kalkhorani ,
Volume 10, Issue 4 (12-2010)

Background & Objectives: Previous studies demonstrated that selected probiotic bacteria elicit beneficial effects in animals. Probiotic bacteria inhibit pathogens growth in the gut, improve lipid metabolism and activate immune system of animals. In the present study Enterococcus spp were isolated from Iranian traditional cheese and their effects on intestine pathogens (Shigella dysenteriae, Escherichia coli and Salmonella Typhimurium) growth, serum lipids level and activation of immune systems in mice were studied.

  Methods: Iranian cheese samples were collected from Ardabil province. Enterococci spp were isolated using selective culture mediums and identified using API kites. Inhibitory effects of isolated Enterococci on growth of Pseudomonas aeruginosa and intestine pathogens (Shigella dysenteriae, Escherichia coli and Salmonella typhimurium) were tested using agar well method . In order to study probiotic activities of isolated bacteria in live animals, NMRI mice were divided into different groups and Enterococci was administrated orally (1 ML/mouse) with doses equal to 2 (6×108 cfu/ml) 3 (9×108 cfu/ml) and 4 (12×108 cfu/ml) MacFarland standard for 2 weeks. After two weeks continues treatment, blood samples were collected from retroorbital sinus and serum levels of cholesterol, triglycerides, LDL and HDL measured using enzymatic method. Interleukins (IL-2, IL-6 and IL-10) levels were measured using ELISA kites.

  Results: Results of this study demonstrated that treatment with faecium species decreases serum cholesterol and increases serum IL-10 level, while it has not showed significant effects on serum levels of glucose, triglycerides, IL-2 and IL-6 (p<0.05). Administration of faecalis species have no significant effects on lipid levels of serum ( p <0.05). Moreover, results revealed that treatment with faecalis species increased IL-6 and IL-10 ( p <0.05). None of the species affected pathogens growth significantly ( p <0.05).

  Conclusion: The results obtained from current study demonstrate that continues treatment with both species can affect immune functions of animal by altering the cytokines profile and treatment with faecium species decreases serum level of cholesterol.

Aziz Homayouni Rad, Hamideh Fathi-Zavoshti , Nazli Douroud, Nayyer Shahbazi, Amin Abbasi,
Volume 19, Issue 4 (1-2020)

Background & objectives: There is a direct relationship between the presence of beneficial microbiota in the gut, development immune system functions and maintenance homeostasis. Hence, the consumption of foods or supplements with postbiotic components has been characterized as one of the most important strategies to modify the microbiome balance and improve the health status of the host. In this study, the concept of postbiotics and their clinical role in host health has been reviewed.
Methods: All articles related to the study subject were searched in the Scopus, PubMed/Medline, ISI Web of Knowledge, and Google Scholar database and studies that examined the effects of postbiotics on diseases were included.
Results: According to available evidences, postbiotics do not need the viability in comparison with their parent cells and they exert health effects like live probiotic cells. Also, their preparation and application in various delivery system is affordable, which this highlights the importance of postbiotics from technological, clinical and economic aspects. These compounds have biological activities including immunomodulation, antimicrobial, anti-inflammatory, anti-oxidant and anti-proliferation, and they can play an important role in modulating the immune system's performance, improving therapies and reducing their possible side-effects in some cases of gastrointestinal disorders and chronic diseases.
Conclusion: The postbiotics as a novel strategy can be used in a wide range of pharmaceutical products for the preventive therapy and improvement of the current therapeutic methods, as well as in food products to delay corruption, increase shelf life, and promote functional foods.

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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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