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Showing 5 results for Pancreas

Hormoz Azimi, Maryam Nasimi, Reza Keikhosravi, Masoud Ghasemi,
Volume 8, Issue 1 (4-2008)

Hydatid cyst disease is a zoonosis disease that is common in both humans and animals. Humans acquire echinococcosis by ingesting viable parasite eggs with their food. The hydatid cyst tend to be in the liver (50-70% of patients) or lung (20-30% patients) but may be found in any other organs of the body, including brain, heart, and bones (less than 10%). Symptoms are often absent, and in many cases infection is detected only incidentally by imaging studies.
This paper presents a case of hydatid cyst who admitted with non specific symptoms such as blotting, recurrent constipation and abdominal distention. Abdominal CT of the patient found low density mass in the right side of abdomen (in small bowel mesentery), without involvement
of the liver, kidney, spleen, and pancreas. The patient candidated for resolution of cyst with lapratomic style. And in operative laparatomy a typical hydatid cyst was found and confirmed by pathology and similar reports were not found by the author regarding the literature.
Mehdi Siavoushifar, Seraj Mohajery, Firooz Amani, Farhood Siavoushifar,
Volume 13, Issue 4 (12-2013)

  Background & objectives: More than 95% of bile ducts diseases are pertain to either gallbladder stone or cholecystitis. Normally, there is not amylase in gallbladder and its presence indicates reflux from the pancreas. The aim of this study was to investigate the association between presence of gallstones and amylase level in gallbladder.

  Methods: In this cross-sectional study 100 patients with cholecystitis were selected and after removal of the gallbladder under sterilized conditions, about 1-5 ml of fluid has been aspirated from bladder. The amylase level of samples was measured in the laboratory and collected data analyzed using statistical tests such as t-test and ANOVA by SPSS 18 software.

  Results : A total of 100 patients with cholecystitis, 42% had measurable amylase in gallbladder (25-65 IU/L). The patients were in the range of 22-92 years old and 47% of them was in the age group of 40-60 years old. The mean age of patients was 48.2 years old (SD=12). There was a significant linear correlation between the gallbladder amylase level and the age of patients (r=0.76, p=0.001).

  Conclusion: Results of our study showed a significant relationship between the formation of gallestones and pancreatic amylase reflux to gallbladder. So, in patients with gallestones, the possible existence of pancreatitis and specially the probability of the pancreas and bile duct obstruction or narrowing should be checked .

َarash Mehri Pirayvatlo , Reza Alipanah-Moghadam , Mohammad Mazani, Farideh Manafi, Vadood Malekzadeh, Ali Nemati, Abbas Naghizadeh Baghi ,
Volume 16, Issue 4 (1-2017)

Background & objectives: Iron overload is involved in the pathophysiology of many diseases including diabetes. In fact, the excess iron by creating free radicals makes damage to pancreas and leads to insulin resistance and diabetes. Andrographolide extract has hypoglycemic and antioxidant properties. This study has surveyed the effects of andrographolide on blood glucose and lipid profile in rats with secondary iron overload.

Methods: In this experimental study, 36 male Wistar rats were randomly divided into 6 groups: the healthy control group, secondary iron overload group, secondary iron overload groups treated with a dose of 3.5 and 7 mg/kg of andrographolide extract, and andrographolide groups treated with a dose of 3.5 and 7 mg/kg of extract. Iron and extract were injected for 6 and 12 days, respectively. Blood samples were taken for measurement of blood glucose and lipid profiles. Data were analyzed using ANOVA test.

Results: The pathological results of samples from liver of animals receiving iron showed that the iron was deposited in the liver tissues. Iron injection significantly increased blood glucose levels compared to healthy control group (p<0.05). In the iron overload group, andrographolide extract with a dose of 3.5 mg/kg or 7 mg/kg significantly decreased blood glucose levels (p<0.05). Iron injections did not increase the serum triglyceride and cholesterollevels. Injections of andrographolide extract with a dose of 3.5 mg/kg and 7 mg/kg, significantly decreased the cholesterol levels compared to iron receiving group (p<0.05).

Conclusion: Results of this study showed that the andrographolide with different doses may be effective in the treatment of diabetes by reducing serum glucose and cholesterol levels.

Naeim Erfani Majd , Zahra Soleimani, Ali Shahriari, Mohammadreza Tabandeh,
Volume 17, Issue 1 (4-2017)

Background and Objective: Since Abelmoschus esculentus plant has many medical benefits, the present study aimed to investigate the therapeutic effects of Okra Powder (Abelmoschus esculentus) against high-fat diet fed-streptozotocin (HFD/STZ)-induced diabetic rats.

Methods: In this experimental study, 25 Wistar Albino female rats were randomly divided into 5 groups: I: control group; II: healthy rats receiving A. esculentus (200 mg/kg); III (HFD/STZ group): Rats fed with high-fat diet (HFD) (60% fat) for 4 weeks and then injected low-dose STZ (35 mg/kg); IV: diabetic rats receiving A. esculentus (200mg/kg) and V: diabetic rats receiving metformin (200 mg/kg). At the end of experiment, biochemical parameters, including Fasting Blood Glucose (FBG), insulin levels, Homa-IR index, ALT, AST and lipid profile were measured. Pancreas and Liver samples were removed, and 5-6 µ sections were prepared and stained by H&E and aldehyde fuchsin staining.

Results: All the biochemical parameters, except HDL-C and insulin, were increased in diabetic rats, while these parameters were decreased in Okra supplementation group compared to diabetic rats (p<0.05). Furthermore, Okra improved the histological impairments of pancreas and liver, including vacuolization, and decrease of β-cells as well as hypertrophy and vacuolization of hepatocytes in diabetic rats.

Conclusion: Okra powder improved biochemical parameters, liver structure and restoration of beta cells of pancreas in diabetic rats. Thus, it can be considered a complementary therapy to improve diabetic patients.

Farin Malekifard, Norooz Delirezh, Rahim Hobbenaghi, Hasan Malekinejad,
Volume 18, Issue 2 (7-2018)

Background & objectives: Several studies have shown that pentoxifylline is an antioxidant and anti-inflammatory agent. Pentoxifylline (PTX), has been shown to exert protective effects on autoimmune disorders. The objective of the present study was to examine the effect of pentoxifylline on histopathology of pancreas in diabetic mice.
Methods: Diabetes was induced by multiple injection of low-dose streptozotocin (40 mg/kg/day for 5 consecutive days) in male C57BL/6 mice. After induction of diabetes, mice were treated with pentoxifylline (100 mg/kg/day i.p.) for 21 days. The nitric oxide levels were evaluated in spleen cell culture supernatant. Pancreases were isolated and stained by hematoxylin & eosin (H&E) and Gomori aldehyde fuchsin (GAF).
Results: Pentoxifylline treatment significantly inhibited the production of nitric oxide (p<0.05). In addition, PTX improved the pancreas tissue. It increased the mean diameter of islets and the number of islets and beta cells. (p<0.05).
Conclusion: These findings indicated that pentoxifylline might have a therapeutic effect against the autoimmune destruction of the pancreatic beta-cells during the development of STZ-induced type 1 diabetes in mice.

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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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