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Showing 3 results for Hypertention

Mohammad Ali Mohammadi, Behrouz Dadkhah, Hashem Sazavar , Naser Mozaffari ,
Volume 6, Issue 2 (6-2006)
Abstract

  Background & Objectives: Controlling diet to regulate blood pressure in hypertensive patients has always been a challenging issue. On the other hand, insufficient supporting systems, non efficient follow-up programs, patients inability to do treatment measures in relapsing period, insufficient following of diet and drug taking, unplanned discharge and poor knowledge of risk factors are among controllable factor that lead to the readmission of the patients. The aim of this study is determining the effect of follow up on blood pressure control in hypertentive patients.

  Methods: In this interventional study, hypertensive patients referring to emergency ward were randomly divided into two case groups (100 patients) and two control groups (100 patients). After collecting data, case group patients were trained in their homes about the role of nutrition, mobility and regular drug use in blood pressure control for 3 months. Then, blood pressure in case and control groups was controlled and mean blood pressure in two groups was compared. The collected data were analyzed by SPSS software using descriptive and analytical statistics.

  Result: 55.4 % of the case and 54.3% controls had family history of blood pressure. Before intervention mean BMI in case and control group was 26.8±5.56 and 28.04±14.66 and after intervention it was 25.96±5.38 and 27.61±14.29 respectively. Before follow up program was implemented, 39.13% of the cases and 35.87% of the controls had regular drug use history. After follow-up this rose to 44.6% and 42.4% respectively. After follow-up program 22.83% of the cases and 17.39% of the controls had referred to emergency ward or a physician once in 3 months. After intervention program, mean systolic blood pressure in cases and controls were 133 and 153 mmHg respectively and this difference was statistically meaningful (P<0.001). After follow-up, systolic blood pressure control in case and control groups was 59.8% and 35.9% respectively and this difference was meaningful (P<0.001).

  Conclusion: Results showed that after training program and home follow-up, blood pressure and weight control were more in case group, than control group, Therefore, we suggest that patient training programs and follow up and home follow-up be used as an effective way in hypertensive patients' health care and their treatment.


Mokhtar Mokhtari , Mehrdad Shariatie , Nazanin Tadayon ,
Volume 7, Issue 1 (4-2007)
Abstract

 Background & Objectives: Spironolactone is a diuretic and antiandrogenic drug and is used in the treatment of hypertention 'secondary hyprealdosteronism congestive heart failure' cirrhosis of the liver, nephrotic syndrome 'androgenic alopecia' gynecomastia and hirsutism. In this research, the effects of spironolactone on the serum LH, FSH, testosterone, dihydrotestosterone, and changes in body weight and testicular tissue in adult male rats, were studied.

 Methods: For this purpose 190 10 g male wistar rats (n=40) were randomly divided into the following grups: control, sham operated (received water) and 25, 50, 100 mg/kg oral spironolactone treated groups. After 14 days body weight and testis weight under laboratory methods, were measured and blood samples were taken from heart and used for the measuring of LH/FSH/testosterone and dihydrotestosterone and then the rates' testes, in order to evaluate the histological changes, were removed and weighed and after obtaining tissue section and staining through HE, they were studied.

 Results: Serum LH level showed a significant increase and testosterone and dihydrotestosterone levels showed asignigicant decrease in 100mg/kg spironolactone treated group ( p 0.05 ) and there was no significant difference among serum FSH level, body weight and testicular weight as compared to control group.

 Conclusion: It can be concluded that oral administration of spironolactone maximum dose for 14 days could increase serum LHlevel and decrease testosterone and dihydrotestosterone levels.


Hosein Dostkamy, Raeouf Mollajavad , Ahad Azami ,
Volume 7, Issue 2 (6-2007)
Abstract

  Background & objectives: Hypertension is a disease with high prevalence and complications and unfortunately the freatment of which is not desirable in many communities including ours. The aim of this study is to assess the therapeutic diet giving and level control of HTN in patients with Hypertension who refered to Ardabil Boali Hospital emergency room and out patient Clinic room.

  Methods: This study was performed on 200 patients who refered to the emergency room and out patient Clinic in Ardabil Boali Hospital from 2003 to 2004 due to high blood pressure. In this study, blood pressure and other factors such as sex, age and the therapeutic modality including compliance to theyapy and kind and quality of drugs were determined, then the data was analyzed by using descriptive statistics.

  Results: Of 200 patients only 1% did not take drug 59.5% of patients were on monotherapy and 39.5% took two or more drugs 33.5% were on Beta blocker (Atenolol) and 11% on ACE inhibitor (Enalapril). Among patients on combination therapy the highest prevalence was B.bloche and ACE.I 40%, and the least one prevalence was diuretic and CCB (2%). All patients on diuretic were pre hypertensive whereas the majority of patients on CCB had stageII hypertension. In patients on multi drug therapy all patients on diuretics + CCB were pre hypertensive but 57% of patients on ACEI + CCB or ACE.I + diuretic had stageII hypertension.

  Conclusion: In this study for combination therapy Diuretic and CCB had the best result in controlling hypertension.



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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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