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Showing 4 results for Candida Albicans

Akbar Pirzadeh, Gholamhosein Ettehad ,
Volume 2, Issue 3 (9-2002)

 Background & Objective: Chronic otitis media infection exists among 1.5-2 percent of people and its purulent discharges can create some difficulties for the patients. Chronic otitis media is mainly due to pseudomonas aeruginosa and staphylococcus aurous. Severe and irreversible damages should be expected unless follow up treatments are exactly performed in such patients. This study was conducted to determine the most prevalent microorganisms involved in otitis infection and their sensitivity to antibiotics.

 Methods: This is a descriptive study in which 60 patients who referred to nose and throat clinics of Ardabil University of Medical Sciences (2000-2001) were selected. Using applicator, some samples were taken from suppurative discharges of middle ear. These samples were then cultured in lactose broth and Nutrient broth. In order to isolate pathogenic microorganism, samples were also cultured in blood agar. Sensitivity of isolated pathogenic microorganism was determined against some antibiotics. The data obtained were analyzed using SPSS software.

 Results: 56 out of 60 patients were culture positive. Microorganisms isolated from suppurative otitis media were Staphylococcus areus (31.6%), pseudomonas aeuroginosa (26.6%), proteus (20%), candida albicans (6.4%), Staphylococcus epidermidis (4.6%), aeuromonas (1.6%) and others (6.4%) respectively. Sensitivity of microorganisms to antibiotics was found to be Ciprofloxacin (94.6%), Co-trimoxazole (66.3%), Cloxacilin (64.3%), Chloramphenicol (64.3%),Cephalexin (64.3%), Erythromycin (60.7%), Amikacin (44.6%), Streptomycin (39.3%), Penicillin (5.4%) respectively.

 Conclusions: Since staphylococcus areus wasthe most prevalent micro-organism in otitis media infection, and isolated microorganisms were more sensitive to Ciprofloxacin, antibiogram test is necessary prior to the treatment of otitis media.

Tooraj Rashidi, Azarmdokht Alamdari Mahd, Arash Dadvand,
Volume 8, Issue 3 (9-2008)

Background & Objectives: Candida Albicans is a fungus that frequently infects diabetic patients. Because it is very common infection in diabetics, we tried to determine the prevalence of infection and the asymptomatic carriers and show factors like age, sex, duration of diabetes and quality of disease control that  probably  have effect on infection.
Methods: In this study 200 diabetic patients were chosen randomly and blood samples were taken for FBS and HbA1C and then skin smears were performed from body folds (Axillaries groin interdigital folds) and probable lesions. The skin samples were cultured in Chrom-Agar medium. Then the gathered data were analyzed.
Results: Overall, from 200 patients, there were 180 (90%) negative culture and 20 (10%) positive cultures. Candidial infection in men and older patients were relatively higher than others. Candida infection in poor controlled diabetes was considerably higher .Infection in type-1 diabetes was more than type-2 diabetes. There was no correlation between duration of diabetes and prevalence of infection.
Conclusion: Candida infection is more common in diabetic patients with poor control, male and older ones.
J Alipoor, M Madani, N Naghsh , M Bayat ,
Volume 15, Issue 2 (6-2015)

  Background & objectives: In recent decades, nanotechnology has been developing in medical field, and most of the nanoparticles are highly valuable in hygienic care. Vulvovaginitis is an infectious disease giving rise to problem in genital tract and Candida albicans is the main cause of Vulvovaginitis.

  Methods: In this study, laboratory effect of gold nanoparticles has been investigated on Candida albicans isolates obtained from patients with Vulvovaginitis. Candida spp. isolates were obtained from 200 patients referring to medical diagnostic laboratory in Isfahan city during 2013, and identified using mycological methods including germ tube, clamydoconidia formation, and culturing on chrom agar media. Antifungal effect of gold nanoparticles was evaluated in concentration of 100, 50, 25, and 12.5 ppm on Candida isolates using well diffusion and microdilution methods. Fluconazole was used as a positive control and results were analyzed by SPSS15 software using Mann-Whitney, Kruskal-Wallis and average differences analysis tests.

  Results: The most averages of clear zone diameter for gold nanoparticle were 18, 15, 12 millimeter, respectively. Minimum inhibitory and fungicidal
concentration of gold nanoparticle was determined 6.25, 12.5 ppm and for fluconazole were 50.25±19.48 and 100.50±38.96, respectively. Based on obtained results antifungal activity of gold nanoparticle was dependent to concentration.

  Conclusion: In current study, inhibitory effect of gold nanoparticles was evaluated against microorganism. Although the laboratories findings are promising, more investigation should be conducted for therapeutic standardization.

Behnam Mohammadi-Ghalehbin , Hannane Javanpour Heravi , Mohsen Arzanlou, Mohammadreza Sarvi ,
Volume 16, Issue 4 (1-2017)

Background & objectives: Candidiasis is a fungal infection which is caused by Candida spp. Candida albicans is the most common agent of candidiasis. This infection may cause various side effects during pregnancy including prematurity, chorioamnionitis, candidal pneumonia, and systemic candidiasis of infants. This research was conducted for determining the prevalence and antibiotic resistance pattern of Candida spp, collected from pregnant women admitted to health centers in Ardabil, Iran.

Methods: Totally, 408 subjects were included in this study. Demographic data and risk factors were recorded using a questionnaire. Two swab samples were taken from vulvovaginal mucus. One swab was used for preparing smear and direct microscopic examination and the second one used for cultivating the specimen. After identification of Candida spp., antimicrobial resistance pattern was determined by disk diffusion method against Fluconazole, Ketoconazole, Clotrimazole, Nystatin and Amphotericin B. Results were interpreted according to CLSI guidelines. The data were analyzed by χ2 and t-test using SPSS-19.

Results: Out of 408 subjects, 143 cases (35%) were positive for candida spp. The Candida albicans with 119 (83.2%) cases was the most prevalent species followed by Candida glabrata, Candida krusei, Candida parpsilosis and Candida tropicalis.According to disk diffusion test, overall 116 (81.1%) isolates were resistant to Fluconazole, 100 (69.9%) to Ketoconazole, 67 (46.9%) to Clotrimazole and 25 (17.5%) to Amphotericin B. Candida spp. had a highest sensitivity (118, 82.5%) to Nystatin. For Candida albicans 97(81.5%) isolates were resistant to Fluconazole and 99(83.2%) isolates to Nystatin. For Candida glabrata 10 (90.9%) isolates were resistant to Fluconazole, and 9(81.8%) sensitive to Nystatin.

Conclusion: According to the results of this study, vulvovaginal candidiasis is prevalent among pregnant women in Ardabil and isolates were significantly resistant against commonly used antifungal drugs. Nystatin was the most effective against Candida spp. As antibiogram for fungal agents is not routinely performed, the similar periodical studies could be useful for choosing appropriate antibiotics in treatment of vulvovaginal candidiasis. 

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