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Showing 12 results for Breast Cancer

Behrooz Dadkhah , Mohammadali Mohammadi ,
Volume 2, Issue 3 (9-2002)
Abstract

 Background & Objective: Breast cancer is the most common cancer occurring among women and the second leading cause of death from cancer among them. The mortality rate of breast cancer is directly related to the stage of the disease when diagnosed, and is reduced by regular breast cancer screening program. This survey is carried out to identify the knowledge, attitude and practice of women in Ardabil about BSE.

 Methods: In this descriptive study, 150 women with 20-25 years of age, were selected through systematic cluster sampling. Knowledge, attitude and practice of them about BSE were investigated through face to face interview, and the obtained data were analyzed using descriptive and analytic statistics.

 Results: 44% of women had some information about breast cancer. 44.7% of them had average information about BSE. There was statistically significant relationship between knowledge of BSE on the one hand and age, marital status and history of previous breast examination on the other. 52% of them believed in BSE for early detection of breast cancer. Their attitude towards BSE was positive (51.3%) and there was a significant relationship between their knowledge and attitude. 18% of the subjects practiced BSE at least once, and their overall practice was in a weak level (46.7%).

 Conclusions: Qualitative researches could be recommended to recognize the factors effective in the improvement of acceptance of breast cancer screening methods among women.


Nayereh Aminisani , Seyedmorteza Shamshirgaran , Farnaz Ehdaivand , Afrooz Mardi ,
Volume 3, Issue 1 (4-2003)
Abstract

  Background & Objective : Breast cancer is the most common type of cancer among women worldwide and accounts for the majority of their deaths due to the cancer. Hence, diagnosing its risk factors is of great importance. In this study the association between abortion and breast cancer risk was investigated.

  Methods : In this Case- Control study in Mashhad, 105 patients with confirmed breast cancer were compared with 105 healthy women who were living in their neighborhood and were the same age. A questionnaire including demographic information as well as same questions regarding the factors associated with conception and emphasising abortion were used to collect the data, which then were analyzed using SPSS ver 9.

  Results : the findings indicated a relationship between breast cancer and history of abortion, compared to women with no history of abortion (OR=2.09 95% CI=1.18- 3.69). Also there was a significant relationship between the frequency of abortion and breast cancer (P=0.008 ). but odds ratio was not higher among women whose age at first abortion was less than 20 years. Also abortion before first full- term pregnancy increased breast cancer risk (OR= 5.97 95% CI=1.18-19.6). But the age at the time of abortion did not have any effect on the breast cancer risk.

  Conclusions : The findings suggested that the risk of breast cancer has a positive relationship with frequency of abortion and the risk is even higher if the abortion occurs before the first full-term pregnancy. Thus, health interventions seem to be necessary in this regard.


Parvin Yavari, Uadollah Mehrabi, Mohammad Amin Pour-Hoseingholi ,
Volume 5, Issue 4 (12-2005)
Abstract

 Background & Objectives: Breast Cancer is among the most common types of cancer in women which in case of early diagnosis and treatment can increase women’s chance of survival. This study was performed in two case and control groups.

 Methods: This case-control study which was based on hospital records was conducted on 303 breast cancer patients and 303 control women. The collected data were analyzed by SPSS using Chi-square.

 Results: The study revealed that there were significant differences between the cases and controls with regard to knowledge (p<0.001) and practice (p<0.001) of breast self-examination. 61% of the cases and 32% of the controls mentioned BSE as a necessary measure for the early diagnosis of breast cancer. 76% of the cases and 47% of the controls were not aware of the proper time for BSE (p<0.001). More than two-third of the subjects in each group did not know the proper time and the necessity of BSE in menopause and pregnant women and these was a statistically significant difference between two groups in this regard (p<0.001). Women in case group had done more frequently than controls (p<0.04). Moreover, the BSE intervals in two groups was statistically significant (p<0.01). There was also a significant difference between the reasons of refusing to do BSE in two groups (p<0.05). Subjects in neither group had regularly referred to a physician for examination and early diagnosis.

 Conclusion:Since the knowledge and practice of women and their referring to a physician for breast examination is inadequate, it seems necessary to devise educational program about doing monthly BSE and hold educational courses to promote women’s knowledge concerning the early diagnosis of breast cancer as well as its appropriate and regular performance.


Davar Amani , Mohammadhasan Zahir , Mojtaba Karimzadeh, Sadegh Feizollah Zadeh, Mohammadhosein Dehghan ,
Volume 7, Issue 4 (12-2007)
Abstract

 Background & Objective: Tumor-infiltrating lymphocytes (TILs) develop as recognition and defense against malignant cells by the host immune system. T cells are the most tumor infiltrating immune cells. There are controversial data about intratumor T cells and many have proposed diverse mechanisms for dysfunction of TILs. The aim of this study is analyzing Tumor Infiltrating T lymphocytes in patients with breast cancer by immunophenotyping.

 Methods: Sixteen women suffering from breast cancer were examined thirteen of them were confirmed histologically to be invasive ductal carcinoma (IDC). Tissue samples from patients and matched control group were processed for analysis by flow cytometry.

 Results: Results indicated that human breast cancer contain variable numbers of TILs. No significant changes in the percent of intratumor CD45+, CD3+ and CD3+/CD45+ cells were observed between studied group. Also there were no significant differences between cancer patients (group 1 and 2) and control group in the case of infiltration and activation status of T cells subpopulations. CD4+ cells in IDC patients and CD8+ cells in patients with other tumors (ILC+AMC) were the most infiltrated TILs. Intratumor TCD8+ cells expressed HLA-DR markers significantly more than CD25 as activation marker. In this investigation we could not find any correlation between TIL and both size and clinical stages of tumor.

 Conclusion: An immune infiltrate is an invariable finding in breast cancers, with considering the activation marker expression, TIL may be activated, albeit partially. Understanding the insensitive and/or suppressive nature of cancer cells to the immune system may provide important insights into tumor escape mechanisms as well as the development of anti-cancer strategies.


Sousan Salimipormehr , Noorosadat Kariman, Zohreh Sheykhan, Hamid Alavimajd,
Volume 10, Issue 4 (12-2010)
Abstract

  Background & Objectives: Breast cancer is one third of all kinds of cancers and the second reason of death in women. Prevention and screening can decrease affection and death rate. The aim of this study was to determine the breast cancer screening tests performance and affecting factors in women referred to Ardabil’s Health and Medical Centers in 2009 .

  Methods: In this descriptive-analytic study, 300 women referring to Ardabil’s Health and Medical Centers were chosen by multistage sampling. The information was collected through the researcher-made questionnaire including two parts: Knowledge and Attitude questions and a form about demographical characteristics, family, social and economic factors, risk and women-midwifery factors. For analyzing the data, SPSS software version 16, and descriptive and deductive statistic tests were used .

  Results: The percentage of screening tests including self-examination, clinical examination and mammography consequently were 4%, 4.7% and 3.7%. There was significant relationship between breast self-examination and education (p =0.003), knowledge (p =0/002) and attitude (p=0.004). No significant difference was observed between insurance status and history of hormone therapy and breast cancer screening tests.

  Conclusion: In regard to the low rate of breast cancer screening conducted and determining the affecting factors, the appropriate educational programs and interventional research are emphasized .


Behzad Davarnia, Parvin Mehdipour , Morteza Arei, Seiyed Saeid Hosseini-Asl ,
Volume 12, Issue 2 (6-2012)
Abstract

  Background & Objectives : Breast cancer is among the most frequent disorders among the world. BRCA1 gene was known as a tumor suppressor gene which its loss could be resulted in various destructions in genome. Therefore, changes occurred in its expression level could lead to increasing the effects of oncogene activity on breast cells.

  Methods : RT-PCR and Q-RT-PCR were used for detecting BRCA1 expression status among 27 primary affected breast cancer patients. The association between its expression status and histopathologic data had been evaluated by statistical assays.

  Results: Eighty-five percent of patients showed BRCA1 expression and this expression as well as its quantity had significant associations with tumor grade. It was found that tumors with low levels of BRCA1 expression tend to have higher grades.

  Conclusion : BRCA1 has an important role in suppressing breast tumorogenesis. Corresponding to some of the previous reports, our findings revealed the role of decreasing in BRCA1 expression level as one of the factors which allows tumors to progress.


Maryam Ghorbani , Yahia Sokhangouei , Heidar Sadeghi ,
Volume 13, Issue 3 (9-2013)
Abstract

  Background & objectives : The surgery of breast cancer like any other surgeries may bring about some problems and complications, which the knowledge of these problems may be an effective way for prevention or dealing with the complications. The motor and sensory impairments in the upper limb of the surgery side necessitate the utilization of the rehabilitation methods. The main purpose of this research was to show the effect of Pilates exercise on range of motion and edema of upper limb in females suffering from breast cancer after going through surgery.

  Methods: This quasi- experimental study was conducted on 25 patients randomly chosen among the patients referring to Cancer Institute. The designed exercise included five "Mat Pilates" moves which were done for 15 sessions until the patient reached fatigue borderlines. Meantime, the control group was doing routine active exercises in physiotherapy center. The range of motion and edema of upper limb was measured before and after applying the designed exercise. For describing the data, the mean and standard deviation, and for inferential analysis, the correlated T-tests and one way analysis of variance were used in level of significance of 5%, to compare the variants before and after applying the designed exercise.

  Results: The results showed a significant difference between the flexion, extension, and internal, external rotation of shoulder, flexion and extension of elbow, flexion, extension, supination deviation and pronation deviation of the wrist and forearm before and after experiment in Pilates group. While in the control group, flexion, extension, internal and external rotation of shoulder, flexion and extension of elbow, and flexion of wrist showed a significant difference before and after the experiment.

  Conclusion: The use of Pilates exercise after mastectomy surgery can increase the range of motion of the upper limb in the involved side of the patients, and decrease the edema, and improve the motion of the upper limb.


A Mohammadi, B Baradaran,
Volume 15, Issue 3 (9-2015)
Abstract

  Background & objectives: Cancer is one of the most causes of mortality in worldwide. Components derived from natural plants that induce apoptosis are used for cancer treatment. Therefore investigation of different herbal components for new anti-cancer drug is one of the main research activities throughout the world. According to low cost, oral consumption and easy access to the public extracts of Urtica dioica, in this study we aimed to investigate the effectiveness of this herb on MDA-MB-468 breast cancer cells.

  Methods: Cytotoxic effect of Urtica dioica extract was measured using MTT assays. To show induction of apoptosis by this plant TUNEL and DNA Fragmentation test were performed.

  Results: In the present study dichloromethane extracts noticeably killed cancer cells. IC50 values related to human breast adenocarcinoma cell line MDA-MB-468 were 29.46±1.05 µg/ml in 24 hours and 15.54±1.04 µg/ml in 48 hours. TUNEL test and DNA Fragmentation assay showed apoptotic characteristic in the extract treated cells.

  Conclusion: The results showed that MDA-MB-468 cells after treatment with dichloromethane extract of Urtica dioica, induces apoptosis in MDA-MB-468 cancer cells which may be useful in the treatment of cancer.


Faranak Hasanpour, Kamaleddin , Hamidi , Saber Zahri, Saeeid Latifi Navid ,
Volume 17, Issue 2 (7-2017)
Abstract

Background & Objectives: Breast cancer is one of the most common cancers of women in the world. Apoptotic pathway is one of the most important pathways to deal with cell damage, especially cancer, which is usually blocked in this disease. One of the main enzymes to set up this pathway is JNK (1,2,3α,3β), which is activated by cellular stress.
Methods: In this study, breast cancer cells with the origin of MCF-7 cell lines were cultured in RPMI medium using 10%fetal bovine serum.Then , they were subjected to heat (42 & 45 ̊ C) for 1,2,4,6 and 8 hours under X-ray and γ-ray radiations for 1,2,3 and 4 hours as well. Their viability and enzyme level were evaluated by MTT and ELISA tests, respectively.
Results: The obtained results showed that abiotic stresses including heat and radiations resulted in JNK level increase and recovery of apoptosis pathway function in breast cancer cells. In addition, they led to decreased of cell viability and increase of JNK level depending on the duration and kind of stress.
Conclusion: The results in this study showed abiotic stress directly affected the JNK level. Increase of this enzyme in the cell resulted in activity of JNK apoptosis pathway. We hope to find methods to help to cancer treatment by means of more studies on JNK enzyme and relevant pathways.
Navideh Haghnavaz, Faezeh Asghari, Zeynab Sattari, Monire Babaei, Tohied Kazemi,
Volume 18, Issue 4 (3-2019)
Abstract

Background & objectives: Breast cancer is one of the most important cancers in women worldwide. Taxol as a chemotherapeutic agent, is used for treatment of breast cancer.The aim of this study was to investigate alterations in the expression of mir-1246 and mir-224 in four breast cancer cell lines after Taxol treatment with the goal of introducing them as a biochemical marker for determining response or resistance of breast cancer to the Taxol therapy.
Methods: In this in vitro study, four breast cancer cell lines including MCF-7, MDA-MB-231, SKBR-3 and BT-474 were cultured in RPMI1640 medium supplemented with 10% FBS and antibiotics. Then, MTT assay was performed to determine IC50 concentration of Taxol. Cells were treated for 24 hours and then RNA extraction and cDNA synthesis were performed. Alterations in the expression level of mir-1246 and mir-224 were quantitated using qRT- PCR.
Results: After treatment with Taxol, the expression level of mir-1246 was significantly up-regulated in two HER2-overexpressing cell lines, BT-474 (113 fold) and SKBR-3 (1.4 fold), and down-regulated in two HER2-negative cell lines, MCF-7 (45.5 fold) and MDA-MB-231 (7.7 fold). Expression of mir-224 was detected only in two cell lines including SKBR-3 and MDA-MB-231, and was down-regulated after treatment with Taxol (2.1 and 17.2 fold, respectively).
Conclusions: According to the different pattern of alteration in the expression level of mir-1246 in HER2-overexpressing breast cancer cell lines compared to HER2-negative cell lines after treatment with Taxol, this miRNA could be a useful biomarker for responsiveness to Taxol in  different types of HER2-positive and -negative breast cancers.
 
Parisa Kerishchi Khiabani , Sayeh Bidaran ,
Volume 19, Issue 2 (9-2019)
Abstract

Background & objectives: Allium cepa has anti-cancer, anti-oxidant and anti-inflammatory properties due to flavonoid compounds. Allium cepa can prevent the onset and progression of cancer by removing free radicals. In this study, the preventive effect of Allium cepa in preventing the proliferation of breast cancer cells in BALB/c mice was evaluated.
Methods: In the present study, Female BALB/c mice at 6–7 weeks of age were subjected to the abdominal mammary gland subcutaneous injection with 5×106 viable 4T1 cells. Eight mice were placed in 3 groups: healthy group, the patient without treatment and the experimental group. The experimental group received Allium cepa root juice, three weeks before induction of disease. Daily, each mouse in the experimental group received 0.1 ml / 100 g BW / day fresh Allium cepa root juice. Seven weeks after induction, the mice were exposed to deep anesthesia. During the test, the mice were weighed every other day and after the appearance of the tumor, by the end of the seventh week, the volume of the tumor was measured using digital caliper and the tumor mass was removed and weighed. The spleen was removed from the body and cultured in 1640-RPMI medium containing 10%, FBS, and ELISA test was used to measure IFN-γ and IL-4 levels. Data analysis was performed using SPSS software version 18. One-way variance analysis was used to assess the difference between the groups and, if it was significant, Tukey's post hoc test was employed to determine the differences between the groups. Also, p-value less than 0.05 were considered as the level of significance for examining the hypothesis test and deciding whether or not to reject the hypothesis.
Results: The weight of mice in all three groups increased and tumor weight and tumor volume decreased significantly in the experimental group compared to the patient group (sham) (p<0.001, p<0.0001 respectively). In the experimental group, compared with the patient group, the levels of IFN-γ (p<0.001) and IL-4 levels decreased significantly (p<0.001).
Conclusion: Based on the results of this study, the use of Allium cepa can prevent and reduce the growth and proliferation of cancer cells and disease progression in breast cancer mouse model.
 
Mohammad Reza Izadpanah, Ali Saleh Zadeh, Mohammad Zaiefi Zadeh, Mohammad Nik Pasand,
Volume 19, Issue 2 (9-2019)
Abstract

 
Background & objectives: Breast cancer is one of the most important causes of cancer deaths especially in developing countries. However, some synthetic compounds such as thiosemicarbazone and its metal derivatives can play a very significant role in reducing the death rate from cancer. The aim of this study was to investigate alterations in the expression of BRCA1, p53 and Bcl-2 genes in breast cancer cell line.
Methods: In this study, the effect of pyrazole derivative of thiosemicarbazone (T) as well as T-bound iron oxide magnetite nanoparticles (T/ Fe3o4 np) were investigated on expression changes of Bcl-2, BRCA1 and p53 in MCF-7 cells. For this purpose, the toxicity of the compounds was first measured using the MTT reaction for 24 hr. Then, the mRNA expression levels were evaluated using real-time PCR reaction.
Results: The results showed a high toxicity for the nano-pyrazole derivative of thiosemicarbazone magnetite so that; the fatality rate for treated thiosemicarbazone magnetite derivative cells was much higher than the compound without any nanoparticle. Also, real-time polymerase chain reaction analysis of gene expression indicated a high effect of the derivative on increasing the expression levels of BRCA1 and p53 genes and also decreasing the Bcl-2 gene expression of Bcl-2.
Conclusion: The use of anticancer compounds like thiosemicarbazone which bound to iron oxide nanoparticles would increase the toxicity of the anticancer compounds along with enhancment of delivery of them with high solubility to target tissue.
 

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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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