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Abbas Karimi , Morteza Jabbarpour Bonyadi, Mohsen esmaeili, Saeid Dastgiri ,
Volume 12, Issue 3 (autumn 2012)
Background and Objectives : Familial Mediterranean Fever, an autosomal recessive disorder, is the most common and well known periodical fevers syndrome. Disease is mainly prevalent among non-Ashkenazi Jews, Arabs, Turks and Armenia. According to the geographical location of North-West of Iran, neighboring with two high risk FMF population (Turkey and Armenia), the prevalence of FMF in this region of Iran is not unlikely. The aim of this study was to estimate the carriers rate of FMF common mutations in healthy control people. Results can be potentially useful to estimate prevalence of disease.
Methods : Randomly 200 samples from healthy people [non-FMF] from North-West of Iran selected. After taking consent, DNA was extracted from blood samples of these groups. Then mutations were evaluated using ARMS-PCR and RFLP-PCR techniques.
Results : from 400 studied alleles, 44 and 7 mutant alleles were found for E148Q and V726A respectively. For 2 other mutations, no mutant alleles were found. The total allelic frequency for these four common mutations was 0.132. The carriers rate was 23.4%.
Conclusion : This study showed that E148Q has high mutation frequency relative to other mutations in North-West of Iran.
Mohammad Sofiabadi, Mohammadhousein esmaeili, Hashem Haghdoost-Yazdi , Moustafa Aali,
Volume 17, Issue 3 (autumn 2017)
Background & objectives: Diabetes mellitus cause cognitive defects. Royal Jelly has been claimed to improve the neurological damage caused by diabetes. In this study, the effect of oral administration of royal jelly on memory and passive avoidance learning was studied in diabetic male rats.
Methods: This experimental study was conducted in Qazvin University of Medical Sciences on 48 male Wistar rats. The animals were divided into control, diabetic without treatment, diabetic recipient of glibenclamide (600 μg/kg) and three diabetic groups treated with 50, 100 and 200 mg/kg royal jelly (n=8). Diabetes was induced in the animals by intraperitoneal injection of streptozotocin (60mg/kg/ip). Treatment in the groups performed by gavage from the onset of hyperglycemia for 30 days. At the end of the test, the passive avoidance learning and memory and blood glucose were measured. Data were analyzed by by SPSS software using ANOVA and post-hoc LSD tests, and p<0.05 was considered significant.
Results: Diabetes reduced the latency time of dark room entering. Royal jelly treatment delayed the entrance to the dark room significantly at 24 h, 48 h and 2 weeks after the shock, especially at doses of 100 (p<0.05) and 200 mg/kg (p<0.01) compared to untreated diabetic animals.
Conclusion: According to the results, diabetes causes memory impairment, and royal jelly administration can reduce the memory impairment due to diabetes.
Mohammad Hossein esmaeili, Zohrea Rozbahani,
Volume 18, Issue 3 (autumn 2018)
Background & objectives: Epidemiological Studies have shown that diabetes increase the risk of developing Alzheimer’s disease (AD).also several studies have confirmed that long term use of Metformin (Met) improves cognitive function in diabetic patients. The aim of the present study was to investigate the effects of Met on learning and memory in diabetic and non-diabetic rats.
Methods: Animals were divided into 2 groups including healthy and diabetic group. In healthy group, normal rats subdivided into control, saline and Met groups which received saline or Met (500mg/kg) and in diabetic group including DM, DM+saline and DM+Met subgroups, diabetic rats received saline or Met (100, and 200mg/kg) for 20 days. Diabetes was induced by intraperitoneal injection (ip) of streptozotocin (STZ).
Results: Our results showed that Met (500mg/kg, ip) impaired spatial learning but improved spatial memory in normal rats. The results also showed that Met improved learning and memory in diabetic rats in a dose dependent manner, so that the rats of DM+Met group compared to DM+saline group found platform in less time and with less distance traveled. Met also increased the percentage of time elapsed and the distance swum in the target quadrant in diabetic rats during the probe trial.
Conclusion: An intraperitoneal injection of STZ resulted in a significant decline in learning and memory and treatment with Met can enhance learning and memory in a dose dependent manner, therefore, it is useful for treatment of cognitive impairment in diabetic patients.