[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
Indexing & Abstracting::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Creative commons

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

..

Search published articles


Showing 2 results for Spotin

Adel Spotin, Monireh Mokhtari Amirmajdi , Mojtaba Sankian, Abdolreza Varasteh, Ali Akbar Shamsian, Fatemeh Vahedi ,
Volume 12, Issue 1 (spring 2012)
Abstract

  Background & objectives: Hydaticosis is a zoonotic helminthic disease of human and other intermediated hosts in which larval stages of the tapeworm Echinococcus granulosu transfect human. The liver and lung are the host tissues for the hydatid cyst . It is unknown which mechanisms are involved in infertility of the cyst and suppression of the fertile cyst. This study was aimed to evaluate the expression of the apoptosis inducing-ligands such as TRAIL and Fas-L in germinal layer of the cyst and human normal tissue surrounding the cyst that is one of the unknown host innate immunity mechanisms against the hydatid cyst.

  Methods: In this study, four isolated hydatid cysts were used which had been diagnosed in patients by radiography and parasitological examination in Mashhad Ghaem hospital. Furthermore, the germinal layer of the cyst and accompanied normal peripheral tissues were separated by scalpel in sterile conditions. After homogenization, expression of TRAIL and Fas-L genes were studied by semi-quantitive RT-PCR method.

  Results: The TRAIL and Fas-L showed significant higher level expression in germinal layer of infertile cyst than the fertile cyst and host normal tissues.

  Conclusion: The host tissue-induced apoptosis of germinal layer of the fertile cysts is probably one of the infertility mechanism in patients with hydaticosis


Mahmoud Mahami-Oskouei , Mehdi Mohebali, Adel Spotin, Zahra Alizadeh,
Volume 18, Issue 3 (autumn 2018)
Abstract

Leishmania parasites as the causative agent of leishmaniasis belong to Trypanosomatidae family. Parasite, vector, vertebrate host and environment are major factors in pathogenesis of Leishmania
Parasite dependent factors are virulence factors which exist in Leishmania species such as LPG, GP63. In recent years, the importance of these factors in the field of vaccine and drug has been considered by researchers. Sand fly biting behavior and salivary gland proteins are vector dependent factors which are effective in the Leishmania pathogenesis. Age, gender, nutrition, immune system, infectious diseases, genetic, occupation, socio-economic characteristics, and habitat are vertebrate host mediated factors. Temperature, rainfall, wind and its speed, soil, and continuous changes in climate are also environmental factors. Therefore the aim of this study was to evaluate the pathogenesis of Leishmania parasites.
 

Page 1 from 1     

مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
Persian site map - English site map - Created in 0.13 seconds with 30 queries by YEKTAWEB 3925