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Showing 7 results for Sharghi

Behzad Skandaroghli, Vadoud Novrozi , Afshan Sharghi , Firouz Amani,
Volume 11, Issue 2 (summer 2011)

  Background & objectives: The most common causes of mortality in patients with head trauma are epidural and subural hematomas. In the last three decades because of improvements in saving and monitoring patients in intensive care unite (ICU), the therapeutic outcomes have been improved dramatically. The aim of this study is to clarify the factors affecting treatment outcomes of patients with epidural and subdural hematomas in Fatemi hospital in Ardabil.

  Methods: The subjects of the study were selected from 109 recorded files in Ardabil Fatemi hospital in years 2001-2006. Data were analyzed by descriptive statistical methods, chi-square and Student's t-test using SPSS software.

  Results: Sixty nine (63%) and 40 (37%) of patients had epidural and subdural hematomas, respectively. The mean age of patients was 33. GCS at the time of admission was 10 and mean hospitalization days in neurosurgery section and ICU were 6 and 8 days respectively. Ninty two (84%) of patients were men and 17 (16%) were female. According to Glosco system, treatment autcome of 76 (70%) patients was desired and that in 33(30%) patients was poor. Nine (13%) of patients with epidorel hematomas and 23 (53%) patients with subdural hematomas were died.

  Conclusion : This study showed thattype of hematoma (epidural and subdural), age, length of ICU stay and GCS at the time of admission affect the treatment outcomes.

Parviz Molavi , Zahra Shahrivar , Javad Mahmodi Garaee, Sajjad Bashirpor , Afshan Sharghi, Fatemeh Nikparvar ,
Volume 11, Issue 3 (autumn 2011)

  Background & Objectives: Bipolar disorder in children and adolescents is a childhood critical disorder with negative course and outcome consequences. The aim of this study was determination of six-month outcome predictor factors (recurrence rate, the rate of hospitalization, severity of illness and recovery rates) in manic and mixed bipolar disorders of children and adolescents admitted in Tehran Rozbeh hospital.

  Methods: In this prospective Cohort study, 80 patients with bipolar disorder (10-18 year's old) admitted in Tehran Roozbeh Hospital from January 2009 to July 2010 were selected. The available sampling method was used for selection. Participants at admission, discharge, and follow-up at 3 and 6 months, were evaluated by using researcher made questionnaires, K-SADS (to confirm the diagnosis), CDI ( Children Depression Inventory) or BDI ( Beck Depression Inventory) , YMRS ( Young Mania Rating Scale) , CGI- S ( Clinical Global Impression Scale) , CGAS ( Children's Global Assessment Scale), CGI-S ( Clinical Global Impression Scale) and PAS ( Premorbid Adjustment Scale) . The data were analyzed by Pearson correlation coefficient and Multivariate regressions .

  Results: The results showed that disease outcome was not associated with age. Gender (male) had correlation with mania severity in 6-month follow-up. Disease duration predicted recurrence rate and severity of disease. Manic type disorder was related with mania severity, and mixed mania predicted mania severity negatively in 6-month follow-up. Therapeutic compliance was correlated with mania severity (negative correlation) and improvement rate (positive correlation). Presence of psychosis was correlated with recurrence rate positively in 6-month follow-up. Co-morbidity with ADHD ( Attention Deficient /Hyperactivity Disorder) predicted clinical global improvement (CGI-G) negatively and mania severity positively in 6-month follow-up. Pre-morbid coping showed negative relationship with mania severity and positive relation with global improvement rate in 6-month follow-up.

  Conclusion: Our results showed that gender of patients, duration and manic type of disease, presence of psychosis at admission have a direct relation with inappropriate outcome of manic and mixed bipolar disorders of children and adolescents. These findings emphasize necessity of special curing during treatment.

Mehrnaz Mashoufi, Robab Nazari, Roghayieh Shirinkam Chouri, Afshan Sharghi, Afrouz Mardi, Maryam Azari ,
Volume 12, Issue 3 (autumn 2012)

  Background & Objectives : Bacterial vaginosis is a condition which is determined by changes in microbial ecosystem of vagina and is considered as a preventable risk factor for preterm delivery. This study was conducted to assess the effectiveness of bacterial vaginosis screening program in routine prenatal care and its effect on decreasing preterm labor.

  Methods: This clinical trial study was conducted on 474 pregnant women at gestational stage between 2007 and 2008. The participants were randomly divided into 2 groups: intervention group and control group. Screening was performed in intervention group with Amsel's criteria (3 of 4 needed for diagnosis). Positive cases were given clindamycin cream (2%) for one week. The outcome of the delivery was assessed in both groups afterward. Data were analyzed by SPSS11 software using descriptive statistics.

  Results: There was no significant difference between two groups regarding pregnancy rank, wanted and unwanted pregnancy, insufficient weight gain, mother vaccination and complication of pregnancy. Bacterial vaginosis was observed in 17 out of 216 (8%) in the intervention group and then treated. Prevalence of preterm delivery in the intervention and control groups were 3 (1.4%) and 12 (4.7%), respectively. The relative risk was protective (RR: 0.3, DR: 0.033, NNT: 30).

  Conclusion: Screening and treatment of bacterial vaginosis in pregnant women could significantly decrease the rate of preterm delivery.

Hasan Ghobadi, Afshan Sharghi , Jila Sadat-Kermani,
Volume 13, Issue 2 (summer 2013)

  Background & Objective: Lung cancer is one of the most common cancers in the world and is considered as one of the top five cancers in Iran. The aim of this study was to evaluate the epidemiology and risk factors for lung cancer in Ardabil.

  Methods: This cross-sectional study was done in Ardabil province since May 2009 to May 2011. Subjects were evaluated from two sources the first group was selected from patients of the Imam Khomeini hospital of Ardabil. These patients were underwent bronchoscopic biopsy in this center and their pathological reports were positive for primary lung cancer. The second group included the patients were reported in Ardabil cancer registry center with diagnosis of primary lung cancer and their samples have been sent to the other centers for analysis. We collected the data in a data sheet for each group separately and analyzed through the use of SPSS (ver. 16) statistical package.

  Results: A total of 124 patients with lung cancer enrolled in this study (79% in the first group and 21% in second group). The male gender was dominant among the patients (82.3%) and the mean age of 64.23±9.99 years. In the first group more than half of the patients (54.1%) were urban, 90.8% had a history of smoking (mean 38.67±25.70 packs of cigarettes per year) and the history of opium abuse was high among subjects (34.7%), the positive family history of cancer was 17.3%, and the most common chief complaint at the time of diagnosis was bloody sputum (32.7%). Right upper lobe was the most common site of cancer in bronchoscopy of this group (27.64%) and squamous cell carcinoma was the most common form of malignancy (61.3%).

  Conclusions: This study showed that unlike developed countries and in line with domestic studies, squamous cell carcinoma was the most common lung cancer, and adenocarcinoma was less common. Lung cancer among the men was seen 4.6 times more than women, and smoking was the most important risk factor.

Mohammad-Reza Aslani, Elham Gholizadeh, Hadi Ghobadi, Afshan Sharghi, Hassan Ghobadi,
Volume 19, Issue 1 (spring 2019)

Background & objectives: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and systemic inflammation which is also associated with pulmonary and extra-pulmonary complications. COPD Diagnostic Questionnaire (CDQ) is a valid questionnaire that is used to identify patients with COPD. The purpose of this study was to determine the relationship between the severity of airflow limitation and the CDQ score in COPD patients.
Methods: In this study, 100 patients with COPD and smoking history were included. The diagnosis of COPD was established based on American Thoracic Society (ATS) guidelines: cough and expulsion of phlegm, chronic dyspnea, obstructive spirometric pattern (forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) <70%). Disease severity was classified according to GOLD criteria. After obtaining consent, demographic data, history of smoking, the exacerbation rate in the past year, arterial oxygen saturation (Spo2) and spirometer variables were recorded. Then, CDQ and Modified Medical Research Council (MMRC) dyspnea score were completed. Also, the associations of the CDQ score with FEV1% predicted and clinical parameters of patients were tested.
Results: All studied patients were male. There was a significant relationship between CDQ score with FEV1% (p<0.001), GOLD stage (p<0.01), Spo2 (p<0.01), exacerbation rate (p<0.01) and severity of dyspnea according to MMRC dyspnea scale (p<0.01).
Conclusion: The CDQ can be used to determine airflow limitation, severity of dyspnea and exacerbation rate in COPD patients. Therefore, it is recommended that this questionnaire can be used in primary health centers for identifying and referring of COPD patients.
Farhad Salehzadeh, Afshan Sharghi, Atena Moteyagheni, Saeid Hosseini Asl, Mahsa Mottaghi, Sepehr Sarkhanloo,
Volume 19, Issue 1 (spring 2019)

Background & objectives: MEFV gene has a major role in Familial Mediterranean Fever (FMF) as an auto-inflammatory disorder. FMF is most often seen in the people of the Mediterranean area. Considering the significant role of the MEFV gene in many rheumatologic diseases and even non-rheumatologic disorders, it is necessary to identify different variations of these mutations in the healthy and normal population of this area.
Methods: 224 healthy people entered into this study. The blood samples were screened for the 12 most common MEFV gene variants according to manufacturer’s instructions. (FMF Strip Assay, Vienna lab, Vienna, Austria)
They filled a questionnaire containing the required information. All patients were initially evaluated for the FMF symptoms and signs in themselves and their first-degree relatives based on clinical criteria. Chi-squared test and t-test were employed for statistical analysis using SPSS ver.24.  
Results: Among 224 cases, 113 cases (50.4%) were male, and 111 cases (49.6%) were female. MEFV mutations were detected in 57 patients (25%) of them, 28 cases were male (49.1%) and 29 cases were female (50.9%). The most frequent mutations were E148Q (18.3%, 41cases), followed by P369S (3.1%, 7 cases), V726A (2.2%, 5cases), A744S (1.3%, 3cases), F479L, M694V and R761H (0.8%, each 2 cases), and eventually K695R (0.4%) respectively. Some mutations such as M694I, M680I (G/C), M680I (G/A), I692del were not seen in these samples. There were compound heterozygous mutations of E148Q/P369S, E148Q/V726A, E148Q/P369S, and P369S / F479L in normal population without any findings in favor of FMF.
Conclusion: Twenty-five percent of the normal population of the northwest of Iran carrying a heterozygous variant of the MEFV gene, E148Q (18.3%) as a most common mutation, which can be considered as a normal variant in the healthy population. The presence of M694I, M680I (G/C), M680I (G/A) and I692del mutations in the normal population can be interpreted with cautiously, while particular compound heterozygous mutations can be considered as normal variants.
Neda Karimi, Afshan Sharghi , Rohollah Baser, Shokofe Banaei, Emran Hajmohamadi,
Volume 19, Issue 3 (atumn 2019)

Background & objectives: Third molar impaction (wisdom tooth) is a widespread phenomenon. It is indeed very important to study the impacted teeth pattern in the community since it will help to develop an appropriate treatment plan for individuals of the community. The aim of this study was to investigate the impaction pattern of mandibular third molar in Ardabil population.
Methods: In this study, the panoramic radiography of 382 patients referred to the Ardabil Dental Clinic, ranging 18-40 years old that had a couple of third molar teeth were investigated. The radiographs were investigated to collect data corresponding to depth-of-impaction, the distance between the canal and inferior alveolar, number of roots, shape and connection between the roots as well as the damages to neighboring structure. The collected data were coded to be analyzed through Chi-square and t- test in SPSS software.
Results: Among the cases, 42.4% and 57.6% of the subjects were male and female respectively. There is no significant difference between men and women for number of roots and the connection between them, whereas noticeable differences between men and women were observed for depth of impaction, distance from Inferior alveolar canal, the shape of the roots and damage to neighboring structures.
Conclusion: The results suggest that most of the cases had vertical angulation, regarding depth of impaction, most of the teeth were categorized in Class-B, regarding distance from Inferior alveolar, and most of the cases were in the vicinity of the canal and had two separate canals. Regarding damage to neighboring structures, most of the cases were categorized as a radiographic bone loss

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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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