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Showing 2 results for Pourghassem Gargari

Hosein Khadem Haghighian , Alireza Farsad Naimi, Bahram Pourghassem Gargari , Akbar Ali-Asgharzadeh , Ali Nemati ,
Volume 10, Issue 4 (winter 2010)
Abstract

 Background & Objectives: Different types of diets and several chemical and herbal drugs are used for decreasing the fasting blood glucose, glycosylated hemoglobin and insulin resistance in type II diabetic patients. New herbal medicines including cinnamon have been considered for controlling diabetes. Since few reports have been presented in other countries and many studies have been done in animal models in laboratory condition, this study was aimed to investigate cinnamon supplementation effects on fasting blood glucose, glycosylated hemoglobin and insulin resistance among type II diabetic patients .

 Methods: In a clinical trial study, 60 male and female patients with type II diabetes mellitus (30 patients in control and 30 patients in treatment group) were selected in Tabriz city, during 1388. The intervention group received 1.5 g of cinnamon (as a capsule containing 500 mg powder, three times daily) for 60 days and control group received placebo. Blood samples obtained from patients to determine the levels of fasting blood glucose, the glycosylated hemoglobin and insulin, before and after cinnamon consumption. Insulin resistance was measured by HOMA score and data were expressed as Mean ± SD and analyzed statistically by Student t-test. p<0.05 was considered as significant .

 Results: After 60 days, the fasting blood glucose levels, the glycosylated hemoglobin and the insulin resistance decreased significantly in the intervention group compared to controls (p<0.05). There was no significant change in the fasting blood glucose levels, the glycosylated hemoglobin and the insulin resistance in the control group at the end of 60 days.

 Conclusion: This study showed the consumption of cinnamon can be useful in the fasting blood glucose, the glycosylated hemoglobin and the insulin resistance control among type II diabetic patients .


Bahram Pourghassem Gargari , Parvin Dehghan, Elham Mirtaheri, Akbar Aliasgarzadeh,
Volume 13, Issue 4 (Winter 2013)
Abstract

  Background & Objectives: Diabetes mellitus is a metabolic disease characterized by hyperglycemia together with biochemical alterations of lipid profile, insulin resistance and inflammation . Considering the high prevalence of hypertension, dyslipidemia and inflammation in type 2 diabetic patients, the aim of the present study was to investigate the effects of inulin on lipid profile, inflammation and blood pressure in women with type 2 diabetes.

  Methods: In this controlled, randomized clinical trial, 49 women with type 2 diabetes (fiber intake<30 g/d, BMI=25-35 kg/m2) were assigned to one of two groups. Experimental group (n=24) received 10 g/d inulin and control group (n=25) received 10 g/d maltodextrin for 8 weeks. Dietary intakes, anthropometric measurements, blood pressure, serum lipids and hs-CRP concentrations were measured at the baseline and at the end of the study. Data were analyzed using SPSS software (verision11.5). Paired, independent t-tests and ANCOVA were used to compare quantitative variables.

  Results: At the end of study, there was a significant decrease in systolic blood pressure (from 135.7 ± 16.2 to 125.9 ± 7.9 mmHg), total cholesterol ( from 192.5 ± 42.8 to 171.0 ± 39.7 mg/dl), triglyceride ( from 223.3 ± 84.2 to 169.9 ± 65.6 mg/dl) and hs-CRP ( from 7.9 ± 3.0 to 5.3 ± 3.0 mg/l) in inulin group compared with the maltodextrin group (p > 0.04 ). Changes in diastolic blood pressures, LDL-c and HDL-c were not significant in inulin group compared with the maltodextrin group. A significant decrease in systolic, diastolic blood pressures, total cholesterol, triglyceride, LDL-c, hs-CRP and significant increase in HDL-c were observed in inulin group compared to baseline.

  Conclusions: Inulin supplementation may improve lipid profile, hs-CRP and blood pressure in women with type 2 diabetes.



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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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