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Showing 25 results for Nemati

Ali Nemati , Mohsen Sagha ,
Volume 2, Issue 3 (Autumn 2002)

 Background & Objective: Menarche is an important event during developing stages in females. Several factors can affect the determination of the menarche age including socioeconomic situation, family customs and nutritional status. Different researches show that obese girls become menarche earlier than thin ones. Regarding the importance of nutrition in menarche age, the present study was conducted to evaluate nutritional status among girls in Ardabil at menarche age (10-14 years old). The aim of this study was to determine the relationship among anthropometrics (e.g. weight, height, BMI, MAC), nutritional status, economic factors and menarche age.

 Methods: This cross - sectional study was done on 612 primary and secondary school girls at the age of 10-14 during 1999-2000. Height, weight and MAC of these subjects as well as their BMI were calculated. Their nutritional status (24-hour recall and food frequency) and menarche age were studied. Finally, the data were analyzed by SPSS ver.9 and Food Processor.

 Results: There was a significant relation between height and menarche age (P<0.05). Menarche age reduced with increasing of weight and BMI, and the differences were significant (p<0.05). Menarche age of girls whose MAC was less than 22cm was lower than individuals with MAC≥22 cm and this difference was significant (P<0.01). Girls with≥40% caloric intake from fat had lower menarche age than the other groups but this difference was not significant. Food frequencies showed that the most frequently used foods in each week were two kinds of local bread (Lavash and Barbary), sugar, vegetable oil, chocolate, cheese, apple and rice.

 Conclusions: Menarche is affected by anthropometrical factors and nutritional status (particularly fat intake).

Ali Nemati , Mohsen Sagha , Hojatollah Nouzad Charvadeh, Mohammadhosein Dehghan ,
Volume 3, Issue 1 (spring 2003)

  Background & Objective : Nutritionists have traditionally recognized breakfast as the most important meal of the day. The importance of eating breakfast is for growing and nutritional well being of children. While health habits such as eating breakfast, maintaining weight, and sleeping regularly are related to the longevity of adults, very little is known about the health habits of disadvantaged school-age children. This study set out to evaluate eating breakfast among adolescent girls and its relationship with body mass index, weight and nutrient intake.

  Methods : This descriptive cross-sectional study was done on 611 adolescent primary and secondary school girls (10-14 years old) in Ardabil. Anthropometric studies (height, weight, and MAC) and nutritional status (24 hour recall and food frequency) were done, and the students were asked about eating breakfast and other snacks. The collected data were analyzed using SPSS ver. 9 and Food Processor.

  Results : About 16.85% of girls had come to school without eating breakfast. BMI and body weight of these students were significantly more than those of girls who ate breakfast (P<0.05). On the other hand snack intake among the girls who did not use to eat breakfast was more than that among breakfast eaters (P<0.05). The amount of calorie, protein, thiamin, niacin, calcium and iron intake in breakfast-eating girls was more than those among non-eaters (P<0.05). The amount of folacin, riboflavin, calcium and zinc intake in non-eaters was less than recommended dietary allowance of WHO. The result of food frequency showed that the consumption of food such as protein different types of bread, potato, and legume among breakfast eaters was more than their consumption among non-eaters.

  Conclusions : This study indicated that eating breakfast can provide adequate calorie and nutrients but its omission can not only lead to lower calorie and nutrients intake but also have an unfavorable effect on food habit and weight of the students.

Ali Nemati , Ali Majidpoor , Mohsen Sagha ,
Volume 3, Issue 2 (Summer 2003)

 Background & Objective: Nutritional status of individuals and community are influenced by different factors. Investigating nutrition and food problems as well as determining dietary pattern play a crucial role in determining nutrition programs and policies, preventing food deficiency, improving nutrition level and preventing malnutrition diseases. The aim of this study was to determine calorie and nutrients intake, food habit and dietary pattern in rural areas of Ardabil.

 Methods: In this cross-sectional study 250 families from 15 rural areas of Ardabil were selected using simple random method. Nutrition status of all the individuals was studied using 24 hour recall and food frequency. Data were analyzed using SPSS and Food processor.

 Results: This study showed that intake of some nutrients (Zinc, Selenium, Folic acid and Vitamin B2) in the subjects were significantly less than Recommended Dietary Allowance (RDA) of WHO (P<0.001), but intake of protein, iron and calcium was more than the RDA of WHO (P<0.001). Calorie intake of 20% of rural people was less than 75% of RDA(mostly seen among men). The findings of food frequency showed that main foods of rural individuals in Ardabil were local bread (Lavash), potato, egg, milk, biscuit, yogurt, garlic, onion, vegetable fat, butter and tomato.

 Conclusions: This study showed unsuitable intake of some nutrients. In order to improve the nutritional status of these people, regular intake of different groups of foods should be instructed.

Ali Majidpour , Hasan Adalatkhah , Seyedhashem Sezavar , Nayereh Aminisani , Masoud Shabani , Ali Nemati ,
Volume 3, Issue 3 (Autumn 2003)

  Background & Objective : Promoting health has always been considered as one of the basic priorities in international, national, regional and local policies. Moreover, retention and promotion of individual health requires a good knowledge of essentials and priorities of the future. Consequently, determining heslth priorities and devising public health programs and policies is just one of the crucial issues to be considered and implemented by the organizations involved. So a fundamental revising of the health care services based on health promotion indices seems to be necessary in order to increase the influence of health interference programs, extend the quality of health care services and improve activities concerning public health.

  Methods: This project started in 2001 and was defined by precise planning of its organization chart. Its two basic concerns included the current status of health and determining its priorities. The first point, that is the current status of health was performed through investigating the previous researches as well as qualitative and field studies. In this phase of research 1000 urban and 1000 rural families were interviewed about different aspects of health including population characteristics, nutrition, risk factors, treatment habits and so forth. To measure the parameters such as hemoglobin, hematocrite, sugar and lipids, blood samples were taken from members of 200 families who were above 15. Weight, height and blood pressure of all the subjects who were above 15 years of age and weight, height and Mid Arm Circumference (MAC) of the children aged below 6 were measured. The data were collected and scored based on scientific indices and finally the research priorities in the field of health were determined. It should be noted that many people and organizations participated in this research.

  Results : The findings indicated that mortality of children under 5 years of age, casualties, accidents, etc. were among 34 most essential health priorities.

  Conclusions : Regarding the great experience of determining health priorities which was conducted through need assessment and wide cooperation of the public and organizations, it seems important to conduct such researches once in some years and transfer their findings to other sectors in order to prevent wastage of costs, time and labor. This will also lead the researches towards the real needs and necessary interference in order to promote public health.

Manoochehr Barak , Leila Azari-Namin , Ali Nemati , Nategh Abbasgholizadeh , Mehrdad Mirzarahimi , Anooshirvan Sedigh ,
Volume 3, Issue 4 (Winter 2003)

  Background & Objective : Failure To Thrive (FTT) refers to the insufficient physical growth or inability in keeping the desired growth rate in a period to time.

  It is a problem in Iran as far as hygienic nutrition is concerned. FTT is a multifactor problem which is caused by various organic and nonorganic agents. This study was conducted to pinpoint the major risk factors involved in the growth of children under 2 years of age who are the most vulnerable age-group in terms of growth disorders.

  Methods: This case-control study was conducted in 2002-2003 on 120 infants (60 cases with FTT and 60 controls) in Namin health centers. The case group was under the third percentage of their growth chart or they had -2SD in growth chart at least in three months. The control group was composed of infants with normal growth chart.

  The demographic characteristics of parents, and the nutritional and antropometric (height/weight, head circumference) characteristics of the subjects were measured. The collected data were analyzed by SPSS software, using chi-square and ANOVA.

  Results: The findings indicated higher frequency of respiratory infections, diarrhea and vomiting in case group (p<0.05). The control group, on the other hand, outnumbered the case group in terms of the number of infants under 6 months who were exclusively breast-fed (p<0.05). Most of the infants with FTT had a lower birth weight than control group (p<0.05). The number of mothers with lower level of education and those who were housewives and also the number of family members were significantly higher in case group than control group (p< 0.05). However, no significant difference was observed between two groups in terms of frequency of breast feeding and birth rank.

  Conclusions : The results indicated that some risk factors such as respiratory infections, birth weight, education, mother ُ s knowledge, exclusive breast feeding and the frequency of diarrhea and vomiting have far more important role in growth disturbances in children compared to factors such as frequency of breasr feeding and birth rank.

Ali Nemati , Hosein Ali Mohammadi , Hamdollah Panahpoor , Seyedhashem Sezavar ,
Volume 4, Issue 1 (spring 2004)

 Background & Objective: Foods of high fat may increase the risk of coagulation heart attacks. They can also increase coagulating factors and lead to higher mortality due to cardiovascular diseases and heart attacks. The aim of this study was to find out the effect of saturated (butter) and unsaturated (sunflower oil) fat intake on coagulating factors such as factor VII and fibrinogen as well as Bt, serum cholesterol and triglycerides.

 Methods: In this clinical trial 46 male healthy individuals from Ardabil University of Medical Sciences took part in this study (age: 18-28 years old) in 2002. These individuals were divided into two groups. The first group consumed 30 g of butter and the second group took 30g of sunflower oil everyday, for 14 days. Before the fat intake and at the end of first and second week blood sample was taken test to fibrinogen, factor VII, cholesterol, BT and triglycerid. Also during the study the 24-hour food-recall was taken three days a week. The collected data were analyzed with SPSS and Food Processor.

 Results: The results indicated that butter intake increases factor VII significantly at the end of the first and second week (p<0.05). But no significant about sunflower oil. BT decreased after butter intake at the end of first and second week. This decrease was significant at the end of first week (p<0.05). Bt increased significantly after sunflower oil intake at the end of second week (p<0.05). Serum fibrinogen after butter intake decreased significantly at the end of first and second week (p<0.05), but was not significant after sunflower oil intake (p<0.05). There was no significant difference in serum cholesterol and triglyceride level after butter intake, but at the end of first week after sunflower intake serum cholesterol decreased significantly (p<0.05).

 Conclusions: We concluded that the intake of saturated fat can affect factors in a short period of time and sunflower oil can decrease serum cholesterol level and as results increase the bleeding time.

Ali Nemati , Abbas Naghizadeh Baghi, Mohammad Hosein Dehghan ,
Volume 8, Issue 2 (Summer 2008)

 Background & Objectives: Measurement of body Weight and height and determining of body mass index (BMI) according to age is one of the most important international indicators for evaluation of growth and physical health. The present study aimed to evaluate growth indices for schoolgirls 7-19 years of age living in Ardabil to compare with standard reference values and similar studies in Iran .

 Methods: To assess the status of growth pattern of 7-19 year girls in Ardebil during 2005, with a descriptive cross-sectional study, 3996 healthy girls were selected by the multi stage sampling method and their age, body weight, height and body mass index were recorded, then 5,10,25,50,75,90,95 percentile, mean and standard deviation in different age were analyzed and compared with NCHS and selected regions of Iran

 Results: The mean of Height and weight in urban girls is higher than their peers in rural regions. Height growth was more during the ages of 9-12 with its peakin 9 years olds with 6 cm annually. The highest increase in weight was at age13 which was estimated 5.5 kg annually. Mean of height and weight in girls of Ardabil is less than their peers in Tehran, Kerman, Esfahan but more than their peers in Zahedan. Of the height, weight and body mass index percentiles in girls of Ardabil aged 7-19 years were less than their American peers according to National Center for Health Statistics data.

 Conclusion: All of percentiles anthropometric factors in girls Ardabil aged 7-19 years were less than NCHS standard.

Hosein Khadem Haghighian , Alireza Farsad Naimi, Bahram Pourghassem Gargari , Akbar Ali-Asgharzadeh , Ali Nemati ,
Volume 10, Issue 4 (winter 2010)

 Background & Objectives: Different types of diets and several chemical and herbal drugs are used for decreasing the fasting blood glucose, glycosylated hemoglobin and insulin resistance in type II diabetic patients. New herbal medicines including cinnamon have been considered for controlling diabetes. Since few reports have been presented in other countries and many studies have been done in animal models in laboratory condition, this study was aimed to investigate cinnamon supplementation effects on fasting blood glucose, glycosylated hemoglobin and insulin resistance among type II diabetic patients .

 Methods: In a clinical trial study, 60 male and female patients with type II diabetes mellitus (30 patients in control and 30 patients in treatment group) were selected in Tabriz city, during 1388. The intervention group received 1.5 g of cinnamon (as a capsule containing 500 mg powder, three times daily) for 60 days and control group received placebo. Blood samples obtained from patients to determine the levels of fasting blood glucose, the glycosylated hemoglobin and insulin, before and after cinnamon consumption. Insulin resistance was measured by HOMA score and data were expressed as Mean ± SD and analyzed statistically by Student t-test. p<0.05 was considered as significant .

 Results: After 60 days, the fasting blood glucose levels, the glycosylated hemoglobin and the insulin resistance decreased significantly in the intervention group compared to controls (p<0.05). There was no significant change in the fasting blood glucose levels, the glycosylated hemoglobin and the insulin resistance in the control group at the end of 60 days.

 Conclusion: This study showed the consumption of cinnamon can be useful in the fasting blood glucose, the glycosylated hemoglobin and the insulin resistance control among type II diabetic patients .

Reza Mahdavi , Ali Nemati , Eiraj Feizi, Mojtaba Amani , Hosein Alimohammadi Asl, Mohammad Mazani M, Phd4; Nagizadeh Bagi , Abbas , Ali Shadman , Reza Alipanah Mogadam, Asghar Pirzadeh, Mousa Ghayour Nahand,
Volume 11, Issue 2 (summer 2011)

  Background & Objectives: Consumption of ω3 fatty acids supplementation inhibits oxidative stress injury, increases activity of antioxidant enzymes and decreases lipid peroxidation in gastric cancer patients. In this study, we examined effects of ω-3 fatty acid intakes on oxidative stress in gastric cancer patients undergoing chemotherapy.

  Methods: This double blind clinical trial study was conducted on 30 adult patients (15 cases and 15 controls) with gastric cancer during chemotherapy in Ardabil city in 2010. Case and control groups were selected by randomized allocation. Three grams ω -3 fatty acid supplementation (1.8 g EPA & 1.2 g DHA in 10 g fish oil) and placebo were given case and control groups for 45 days, respectively. Anthropometric indices (weight, height & BMI) were measured. Blood samples were taken and then biochemical factors including triglycerides, total cholesterol, HDL and LDL cholesterol, MDA, and total antioxidants were evaluated at the beginning, middle and end of the study . The data were analyzed by using Paired sample t-test, Independent sample t-test and repeated measures test.

  Results: MDA, Weight and BMI of omega group after intervention were significantly more than control group at the end of the study (p<0.05). Weight and BMI were decreased but serum MDA was significantly increased in control group during the study (p<0.05). Weight, BMI , and total antioxidants were significantly increased in omega group during day 30-45, (p<0.05). There were no significant differences in other biochemical factors at the end of study.

  Conclusion: The present investigation shows administration of ω3 fatty acid supplements to gastric cancer patients during chemotherapy increases the total antioxidants capacity and prevents the enhancement of oxidative stress.

Reza Alipanahmogadam , Mohammad Mazani , Abbas Naghizadeh Baghi, Ali Nemati, Mojtaba Amani , Bahman Bashardoost, Amir Mansour Vatankhah , Shahab Bohlooli,
Volume 11, Issue 3 (autumn 2011)

  Background & Objectives: Several evidences show that oxidative stress is high among patients with hemodialysis . This study was aimed to investigate the oxidative stress and serum level of zinc and copper in patients with non-diabetic hemodialysis .

  Methods: In a case-control study, 60 patients with non-diabetic hemdialysis referred to hemodialysis section, Ardabil Bou-Ali hospital, and 60 healthy individuals, matched by age and sex, were selected. In each group, lipid profile, blood glucose, creatinine, urea, total protein, albumin, zinc, copper, malondialdehyde, total antioxidant capacity, activity of glutathione peroxidase and superoxide dismutase were measured. The results were analyzed statistically by using Pearson correlation coefficient and Student-t test.

  Results: The amount of zinc, blood sugar, cholesterol, triglyceride, total protein, albumin, high density lipoprotein-C and low density lipoprotein-C were significantly lower in patients with hemodialysis in comparison with those in normal individuals. T he activity of superoxide dismutase, glutathione peroxidase in red blood cells and serum total antioxidant capacity were significantly high in patients in comparison with those in control group. However, serum concentrations of copper and malondialdehyde in two groups were not statistically different.

  Conclusion : The results of this study show that increase of antioxidant enzymes activity reduces the oxidative stress status in patients with non-diabetic hemodialysis . Zinc deficiency was also observed in these patients.

Eiraj Feizi, Abbas Naghizadeh Baghi , Alireza Rahimi , Seddigheh Nemati,
Volume 12, Issue 2 (summer 2012)

  Background & Objective: Today obesity and depression are two important diseases which are growing all over the world and threat the human health. That how much these two affect each other is a major health question. This study aimed to investigate the relationship between body mass index (BMI) and depression in female students of Ardabil University of Medical Sciences.

  Method: In a descriptive study 230 female students were selected through classified random sampling and their height and weight were measured. To measure the rate of depression a Beck test, and to analyze the data a descriptive method, and finally to indicate the relationship between BMI and depression Pearson correlation through SPSS15 software were used.

  Results : 40% of the students in the depression test were in the normal level, 29% had mild depression, 24% moderate depression and 7% severe depression. In addition 77% of the students, regarding body mass index were in an acceptance level, 14% were overweight and 9% were underweight. Pearson correlation method showed that there was a positive significant relationship between BMI and depression among female students (p≤ 0.01).

  Conclusion: The prevalence of depression in female students of university is 60% and the prevalence of obesity is 14% and there is positive significant relationship between BMI and depression.

Ali Nemati, Reza Mahdavi , Eiraj Faizi, Abbas Nagizadeh Baghi,
Volume 12, Issue 3 (autumn 2012)

  Background & Objectives: Chemotherapeutics induce side effects in patients with cancer . In animal models the intake of ω3 fatty acids during chemotherapy can increase the impact of chemotherapy drugs and reduce their side effects . This study was aimed to determine the fish oilintake on side effects of chemotherapy drugs in patients with gastric cancer.

  Methods: A double blind clinical trial study on 30 adult volunteer patients (15 experiments and 15 controls) with gastric cancer was conducted during chemotherapy in Ardabil, Iran, during 2010-2011 . Experimental and control groups were selected by randomized allocation. About 3 grams ω-3 fatty acid supplementation (1.8 g Eicosapentaenoic acid & 1.2 g Docosapentaenoic acid ) and placebo were given to experimental and control groups for 6 weeks, respectively . Then, the results of data were collected at the beginning, 4 and 6 weeks after intervention of ω3/placebo in both groups and analyzed by using descriptive statistics , Chi -Square , Independent sample t-test and Cochran,s Q test.

  Results: The results of this study showed that there were significant differences of nausea in both group of patients at the end of 6 weeks (p<0.05). A bdominal cramp and nausea significant ly decreased in experimental group during the study (p<0.05). Hair loss , vomiting and diarrhea were reduced in experimental group during the study, but these differences were not statistically significant . There were no significant differences in vomiting , diarrhea and hair loss between two groups at the end of intervention.

  Conclusion: The present study showed that the intakes of fish oil strongly reduce side effects of chemotherapy drugs such as nausea and abdominal cramp. So, this oil supplementation appears to be harmless and useful in patients with gastric cancer during chemotherapy .

Ali Hossain Khani , Ali Nemati, Mitra Naser Saead , Shahnaz Hosseinzadeh, Manoochehr Barak ,
Volume 12, Issue 5 (suppl 2012)

  Background & Objectives : Urolithiasis is the third common urinary disease. While, relationship between the urinary stones and diet is known to some extent, but there are controversies about it. The aim of this study was to determine the association between food habit, nutrients intake and kinds of urinary stone disease.

  Methods: This cross-sectional and descriptive analytical study was performed on 150 patients (91 male and 59 females) with urinary stone disease in Ardabil during 2008-2009. Data of urinary stones analysis, type of stone in the graph, type of stone, preventive emprise and type of drinking water were recorded. Food data were recorded using 24-hour dietary recalls three days in week and food frequency questionnaires. Data were analyzed using SPSS, Food Processor III software, and ANOVA Statistical program .

 Results: Findings showed that the most common and lowest form of urinary stone disease in men and women were calcium oxalate and ammonium phosphate, respectively. There was significant inverse association between beta-carotene intake and the percentage of uric acid stone disease (p<0.05). We observed significant relationship between vitamin A and folacin intake with percentage of uric acid stone disease (p<0.05). There was significant relationship between consumption of cheese and pickles with calcium phosphate stone disease (p<0.05). There was no significant association between other foods and nutrients intake with types of urinary stone disease .

 Conclusion: This study showed the consumption of some nutrients including folacin, vitamin A and some foods such as cheese was associated with the incidence of urinary stone disease. Therefore, taking accurate diet could possibly prevent the incidence of urinary stone diseases.

Ali Shadmanfard, Ali Nemati , Abbas Naghizadeh Baghi, Mohammad Mazani,
Volume 12, Issue 5 (suppl 2012)

 Background & Objectives: The intake of antioxidant supplementations can have key role in prevention of oxidative stress in healthy individuals. Pomegranate has antioxidant effects and may play a role in reduction of oxidative stress in healthy males. Therefore, this study examined the effect of pomegranate juice supplementation on oxidative stress in young healthy males.

 Methods : In semi-experimental study, 14 healthy students living in Dormitories of Ardabil University of Medical Sciences were included. Subjects were given one cup of pomegranate juice supplementation per day for two weeks . Fasting blood samples were taken both at the start and the end of 2-week period to measure the antioxidant enzyme activities such as superoxide dismutase , glutathione peroxidase , paraoxonase - 1, aryl esterase , and the values ​​of serum total antioxidant capacity , glutathione, and lipid profiles . Data were analyzed using descriptive and paired t - test s.

 Results: T he level of serum total antioxidant capacity and activities of enzymes such as superoxide dismutase, glutathione peroxidase, arylesterase, and standardized arylesterase activity were significantly increased at the end of two weeks (p<0.05). The serum level of malondialdehyde was significantly decreased after intervention (p<0.05). Changes were not significant, although the serum levels of glutathione and HDL- cholesterol increased and LDL- cholesterol decreased at the end of two weeks period.

 Conclusion: The results of this study showed that the pomegranate juice supplementation had beneficial effects in helping body's antioxidant defense system and reduction of oxidative stress in young healthy males . This study suggests that the pomegranate juice supplementation can be useful against oxidative stress included in dietaries of young healthy males.

Abbas Yazdanbod, Afshin Hooshyar, Rasool Nemati, Nasrollah Maleki, Gholamreza Hamidkholgh,
Volume 13, Issue 4 (Winter 2013)

  Eosinophilic gastroenteritis is a rare disease characterized by focal or diffuse eosinophilic infiltration of the gastrointestinal system. The clinical presentation is depending on the involved area and its extension into the layers of the gastrointestinal tract. We repor ted a case of eosinophilic gastroenteritis in the setting of cryptogenic cirrhosis which initially appeared as a tumoral obstruction of the 3rd portion of duodenum which is relieved by surgical bypass and two years later presented as eosinophilic ascitis. The patient was treated with corticosteroid with full absorption of ascitis.

Mostafa Nachvak , Sheida Ahani Kamangar , Ali Nemati , Saeid Sadeghieh Ahari ,
Volume 14, Issue 2 (summer 2014)

  Background & Objectives: Epidemiological and experimental evidences suggest that oxidative stress is elevated in children with Down syndrome (DS). Some studies show that consumption of diets with a high content of fruits and vegetables results in a significant reduction in markers of oxidative stress. We investigated the frequency of fruits and vegetables intake in children with DS and the influence of variations in the level of this consumption on biomarkers of oxidative stress .

  Methods: Frequency of consumption of fruit and vegetables by children with DS were recorded by interview with the children’s parents. Serum malondialdehyde (MDA) and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) were also measured as biomarkers of oxidative stress. Data analysed using ANOVA and Student’s t-tests .

  Results : Mean consumption of fruits and vegetables was 4.6 and 0.74 servings per week, respectively. No significant relationships were found between consumption of fruits and vegetables with markers of oxidative stress. Based on our findings, the 65.9 % of the children did not eat any vegetables and the rest of the children consumed less than one serving per day. There was a significant correlation between the frequency of fruits and vegetable consumption (r=0.212 p <0.04).

  Conclusion : There wasn’t any significant relationship between fruits and vegetables consumption and indicators of oxidative stress in children with DS. This lack of correlation could be due to low consumption of fruits and vegetables in children with DS.

َarash Mehri Pirayvatlo , Reza Alipanah-Moghadam , Mohammad Mazani, Farideh Manafi, Vadood Malekzadeh, Ali Nemati, Abbas Naghizadeh Baghi ,
Volume 16, Issue 4 (winter 2017)

Background & objectives: Iron overload is involved in the pathophysiology of many diseases including diabetes. In fact, the excess iron by creating free radicals makes damage to pancreas and leads to insulin resistance and diabetes. Andrographolide extract has hypoglycemic and antioxidant properties. This study has surveyed the effects of andrographolide on blood glucose and lipid profile in rats with secondary iron overload.

Methods: In this experimental study, 36 male Wistar rats were randomly divided into 6 groups: the healthy control group, secondary iron overload group, secondary iron overload groups treated with a dose of 3.5 and 7 mg/kg of andrographolide extract, and andrographolide groups treated with a dose of 3.5 and 7 mg/kg of extract. Iron and extract were injected for 6 and 12 days, respectively. Blood samples were taken for measurement of blood glucose and lipid profiles. Data were analyzed using ANOVA test.

Results: The pathological results of samples from liver of animals receiving iron showed that the iron was deposited in the liver tissues. Iron injection significantly increased blood glucose levels compared to healthy control group (p<0.05). In the iron overload group, andrographolide extract with a dose of 3.5 mg/kg or 7 mg/kg significantly decreased blood glucose levels (p<0.05). Iron injections did not increase the serum triglyceride and cholesterollevels. Injections of andrographolide extract with a dose of 3.5 mg/kg and 7 mg/kg, significantly decreased the cholesterol levels compared to iron receiving group (p<0.05).

Conclusion: Results of this study showed that the andrographolide with different doses may be effective in the treatment of diabetes by reducing serum glucose and cholesterol levels.

Hasan Edalatkhah, Nazila Rahnema Tareghi , Saeeid Sadeghieh Ahari , Ali Nemati,
Volume 17, Issue 2 (summer 2017)

Background & objectives: Acne Vulgaris is a chronic inflammation of pilosebaceous glands. Some studies have indicated the significant decrease of linoleic acid in the sebum composition of the patients with acne. The aim of this study was to determine the probable therapeutic effects of linoleic acid on moderate acne.
Methods: In a double-blind randomized clinical trial, 40 women with moderate acne were divided into two groups, each group with 20 each with 20 samples. After recording the nutritional and demographic factors, the case group received, 100 mg oral doxycycline daily plus 3 gr conjugated linoleic acid and the control group received 100 mg doxycycline daily plus 4-3 oral paraffin capsules as placebo for one month. The number of acne lesions were counted before and after treatment and the mean of   Acne Severity Index (ASI) and Global Acne Grading System (GAGS) were determined for each group. The collected data were analyzed by SPSS software using chi-square, independent t-test and paired t-test.
Results: The mean age was 22.8±5.5, in the case group and21.7±5.1 in placebo group indicating no statistically significant deference (p=0.51). At the end of treatment there was no statistically significant deference between the two groups in decreasing acne (p=0.31). During the treatment, ASI reduced from 129.5±13 to 77±11.6 in the case group and from 132±18.6 to 67.5±11.6 in the placebo group, –but there was no statistically significant deference between the two groups (p=0.37).
Conclusion: It seems using 3 gr oral conjugated linoleic acid daily for 1 month has no effect on remission of acne.
Reza Alipanah_moghadam , Sara Hosseinzadeh, Ali Nemati, Abbas Naghizadeh Baghi , Vadood Malekzadeh,
Volume 17, Issue 2 (summer 2017)

Background & objectives: The relationship between dietary patterns and esophageal cancer has not been documented yet. However, recent studies have shown that the Western dietary pattern is associated with an increased risk of esophageal cancer. The current study was performed a comparative evaluation of the food habits and serum nitrate level in patients with esophageal cancer and healthy individuals in Gorgan city.
Methods: In a case-control study, 44 patients with esophageal cancer (the case group) and 44 healthy subjects (control group) were selected for one year in Gorgan city. Anthropometric factors were measured, and then demographic and dietary data were recorded using general and food frequency questionnaires (FFQs), respectively. Fasting blood samples from both groups were collected to measure serum nitrate levels. Data were analyzed by independent t-test, Chi-square, Fisher, and Monte Carlo tests.
Results: the mean weight, body mass index (BMI) and serum nitrate levels were statistically lower in the case group than in control group (p<0.05). Salt intake, smoking cigarette or hookah was higher in patients than in control group (p<0.05). Based on nutritional habits , consumption of bread , rice, saturated fats, hot tea, sausages and industrial soft drinks was statistically higher in the patient group than control group, but intake of vegetables, fruits, unsaturated fats, honey and grilled meat was lower in patients  than control group (p<0.05).
Conclusion: Consumption of fast foods, hot tea and saturated fats may be associated with esophageal cancer. Serum nitrate levels were lower in patients than control group, probably indicating the need for further research in this field.
Iraj Faizi, Saeid Smaeilpour, Ali Nemati , Khatere Isazadeh, Farideh Faizi, Vahid Montazeri,
Volume 17, Issue 3 (autumn 2017)

Background & objectives:  The use of supplements such as L-carnitine, optimum nutritional support and early feeding after surgery in cancer patients can be important in the prevention of cancer complications. The aim of this study was to determine the effects of early L-carnitine-rich feeding on complications of esophageal cancer surgery and duration of hospitalization.
Methods: In a clinical trial, 50 patients with esophageal cancer under surgery in two equal groups were randomly selected. Nutritional information was obtained using food record questionnaire. Basic blood samples and 24-hour urine samples were taken in order to measure the hematological parameters (like blood cell count, hemoglobin, hematocrit and blood urea) and nitrogen balance, respectively from two groups at the beginning and end of the study. Then, the intervention group received 3 g L-carnitine daily in 3 doses on the first day after the complementary operation, with a routine hospital diet at each meal, and the control group received a routine hospital diet for ten days. Data were analyzed using independent t-test, paired t-test and chi-square test.
Results: The results showed that changes in the mean BUN and nitrogen balance were significantly different after intervention between the study groups (p<0.05). Patients with early L-carnitine-rich feeding had less hospitalization time in hospital wards and were discharged earlier (p<0.05).
Conclusion:  The results of this study showed that early L-carnitine-rich feeding after surgery has probably a positive effect on the duration of hospital stay in patients with esophageal cancer.

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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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