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Showing 7 results for Mousavi

Farzad Izadi , Seyedbehzad Pousti , Fathollah Mousavi , Mohammad Mohseni , Abtin Doroudinia ,
Volume 4, Issue 3 (Autumn 2004)

  Background & Objectives: Recurrent respiratory papillomatosis (RRP) is the most common benign laryngeal tumor and the second common cause for hoarseness in children. Despite its omplete benign histology, it has a great tendency to spread through the respiratory track and frequent recurrences may occur following surgery, possibly due to the virus survival in apparently healthy adjacent tissues. According to the most recent evident experiences, the treatment of choice for RRP disease is repetitive resections with CO2 laser. The present study evaluates the efficacy of adjuvant medical therapies for eradication of this disease in affected children.

  Methods : This was an experimental study with sequential control (self-control). The subjects were children who referred to ENT-H&N surgery dept. of Hazrat-e- Rasoul hospital in Tehran between Mar 1998 and Mar 2001 with chief complaint of hoarseness and respiratory obstruction. Among these children patients with confirmed diagnosis of RRP were selected as study samples and the effect of acyclovir and alpha-interferon combination in reducing the severity and recurrence of RRP was evaluated.

  Results: Totally 18 patients entered this study (10 (55.5%) females and 8 (44.5%) males). The mean age of the patients was 6.5 and 94% of them were the first child of young mothers (under 25 years of age). The signs of respiratory obstruction in most of the cases with a mild to moderate severity was the main cause of referral in 45% of the subjects. Laryngeal lesions were mostly superficial and limited to glottis region. Severity and spread of RRP disease was greater in children under 3, which led to tracheotomy in 3 of them. The combined administration of alpha-interferon and acyclovir, made a significant reduction in disease severity and spread in 55.6% of the patients.

  Conclusion : The findings of this study indicated that combination of acyclovir and alpha-interferon can be effective in reducing RRP recurrences and severity. Nevertheless, because of small sample size(due to rarity of RRP), Further multi-institutional studies are required to obtain a greater sample size and more valid results.

Rahman Parniya , Darioush Savadi Oskuei , Seyedabbas Mousavi ,
Volume 6, Issue 4 (Winter 2006)

 Background & Objectives: Stroke is the third cause of mortality after cardiovascular diseases and cancer. It is also the most common debilitating neurologic disorder. Considering the high prevalence of intracerebral hemorrhage (ICH) and its mortality, it seems quite necessary to study the frequency of ICH risk factors and its mortality related to size and region of hemorrhage.

 Methods: 157 ICH patient units were studied to determine hemorrhage size and region via CT Scan reports. Patients were followed to record the mortality and a questionnaire was filled out for them. The data were analysed by SPSS version 13.

 Results: Females constituted 57.9% of the 157 patients and the rest were males. Mortality rate was 37.6%. Most of the patients were in 70-79 years age group. Hemorrhage had the highest frequency found in putamen (39.4%). Hemorrhage size less than 20 cm3 had the highest frequency among living patients and hemorrhage size in a range of 20-100 cm3 was most common among expired patients. There was a statistically significant relationship between mortality and hemorrhage size (P<0.05). Intraventricular hemorrhage was more frequent among expired patients (p<0.05). There was also a statistically significant relationship between a history of cardiovascular disease and mortality rate (P<0.05).

 Conclusions: Intraventricular hemorrhage and hemorrhage size were significantly related to mortality rate.

Seyedmojtaba SeyedMousavi , Ebrahim Fataei , Seyedjamal Hashemi , Mohsen Geramishoare ,
Volume 7, Issue 2 (Summer 2007)

  Background & Objectives: Pools and Saunas are one of the most public areas that may cause superficial and cutaneous mycoses in humans. So investigating the fungal flora in the mineral swimming pools like Sarein area can remove or reduce the contamination or prevent the probablity of fungal infection.

  Methods: A total of 284 samples from 11 mineral swimming pools were taken of which 214 were from pools, sauna Jacuzzis, tubs and showers which were covered by sterile moquette and 70 were from water in saunas, jacuzzis, tubs and showers which were collected in sterile test tubes. All of the samples were cultured in standard method on sabouraud dextrose agar (SDA), sabouraud dextrose agar+oleic acid (S+O) and sabouraud dextrose agar+ chloramphenichol+cyclohexamide (SCC) medias, then identified macroscopically (colony morphology )and microscopically.

  Results: From 284 samples, 193 were contaminated with fungi. The most frequently isolated species in 11 pools were Aspergillus fumigatus (22/79%), Aspergillus flavus (15/54%), Aspergillus niger (15/54%) and Penicillium (14/5%) respectively. On the other hand, Ulocladium, Sepedonium, Acremonium, Pscilomyces, Stemphylium and Streptomyces with 0.51 % were the least frequently isolated species. In this study, no dermatophytes or other true dimorphic pathogenic fungi were isolated from samples.

  Conclusion: So it can be concluded that routine hygiene inspections such as disinfection of pools, personnel training and following hygienic rules were much effective in lowering the comtamination. Also mineral waters of these pools can be growth inhibitors of pathogenic and dermatophytic fungi.

Shaban Alizadeh , Shahab Bohlooli , Ali Abedi , Seiyed Hadi Mousavi , Behzad Jafazadeh, Norooz Hamrang , Ali Imani,
Volume 10, Issue 4 (winter 2010)

  Background & Objectives: Leptin is a hormone secreted from adipocyte tissue with established role in the differentiation and proliferation of hematopoietic cells. This hormone has major impact on fat metabolism. LIF is a pleiotropic cytokine with extensive hematopoietic, neuronal, and endocrine actions. LIF and IL-6 are leading to decreased level of leptin by activating signaling via their own receptors. Body mass index (BMI) has a direct connection with the leptin. It seems that Hb and HCT levels are also implicated in disease prognosis. This study was conducted to evaluate leptin, LIF and IL-6 serum levels and also to measure the amounts of BMI, Hb and HCT in lymphoid leukemia patients .

  Methods: The study was carried out on 30 leukemia patients (15 cases ALL and 15 cases CLL). Fifteen healthy subjects were considered as control. Serum levels of leptin, LIF and IL-6 were measured by ELISA. BMI was calculated by statistical formula. The amount of Hb and HCT were measured by cell counter. Data was analyzed by SPSS software. Statistical differences between groups were assessed by t test, and p<0.05 was considered significant.

  Results: Leptin serum level showed a decrease in ALL patients (p<0.002), but there was an increase in CLL patients when comparing with control group (p<0.003). BMI and serum levels of leptin, LIF and IL-6 were showed a significant decrease in ALL patients in comparison with control group (p<0.05). Although, LIF serum levels and BMI in CLL patients showed a decrease, a significant increase in leptin serum level was observed (p<0.05). A decrease in IL-6 level was also observed which was not significant. The relation between BMI and leptin serum level in ALL and CLL patients were not significant, nevertheless it was significant in control group (p<0.05). Hb and HCT levels in both ALL and CLL patients showed a significant decrease (p <0.05).

  Conclusion: Findings on serum levels of LIF, IL-6, Leptin, Hb and HCT and also its relations with BMI in ALL and CLL patients suggest that, these factors may have important role in physiopathology of lymphoid leukemia.

Abbasali Imani Foolad, Maryam Hosainzadeh, Seiyed Fazlollah Mousavi ,
Volume 11, Issue 1 (spring 2011)

  Background & Objectives: Pseudomonas aeruginosa is a Gram-negative and aerobic bacterium. Exotoxin A is one of the important toxins produced by the bacterium and it is the main cause of mortality. About 90% of P. aeruginosa strains produce this toxin. Biofilm is a functional consortium of microorganisms attached to the body surfaces and bacteria are embedded in extracellular polymeric substances produced by the microorganisms. This bacterium is nontoxic in the planktonic form, but as a biofilm is highly toxic. In this study, we examined the association between the presence of exo-A gene and antibiotic resistance patterns with biofilm formation in Pseudomonas aeruginosa strains.

  Methods: In this study 110 strains of Pseudomonas aeruginosa isolated from various infections with defined antibiotic resistance patterns were used. The PCR method was used to detect the presence or absence of Exotoxin A gene (exo-A). Ability of biofilm formation was evaluated by spectrophotometry. Association between exo-A gene and antibiotic resistance patterns with biofilms formation was analyzed statistically by Fishers and Chi-square tests.

  Results: exo-A gene was detected in 93 strains (84.5%). Sixty two strains were multidrug resistant and they produced broad spectrum beta-lactamase enzyme. Results showed that, exo-A positive strains had significantly higher ability to biofilm formation in comparison with exo-A negative strains (p<0.05). Also the biofilm formation was significantly higher in multidrug resistant and ESBL producing strains (p<0.05).

  Conclusion: The results of this study indicate that there is a significant association between exo-A gene as well as antibiotic resistance pattern and ESBl producing with biofilm formation in Pseudomonas aeruginosa. Because of importance of biofilms in the pathogenesis of this bacterium, our study could open a new window for investigation of the molecular processes involved in the formation of biofilms.

Darioush Mohajeri , Ali Rezaie , Ghafour Mousavi, Mohammad Mazani, Adel Rezaei-Moghadam,
Volume 12, Issue 2 (summer 2012)

  Background & Objectives: The aim of the present study was to evaluate the protective effects of Crocin on rat high fat diet-induced hepatic steatosis model.

  Methods: For this purpose, male rats were given either standard diet as control, high fat diet for induction of hepatic steatosis and high fat diet plus Crocin through gavage at different doses (25, 50 and 100 mg kg-1/day) for protection of liver steatosis, at a period of 4 weeks in different experimental groups and compared considering serum lipid profile, serum biomarkers of liver tissue injury, hepatic antioxidant activity and liver histopathological changes. The serum levels of triglyceride, total cholesterol, low-density lipoprotein, very low-density lipoprotein, high-density lipoprotein for determination of deleterious metabolic effects, alanine aminotransferase, aspartate aminotransferase for determination of hepatocyte injury, alkaline phosphatase, bilirubin for assessment of biliary function, malondialdehyde and reduced glutathione content for assessment of liver free radical activity, the enzymatic activities of glutathione peroxidase, superoxide dismutase and catalase as indicators of antioxidation in liver tissue, were measured. Finally, the biochemical findings were matched with histopathological verifications.

  Results: After 4 weeks, high fat diet caused deleterious metabolic effects, including hypertriglyceridemia, hypercholesterolemia and liver dysfunction. Rats fed high fat diet alone showed increased activities of hepatocellular enzymes in plasma, significant decline in antioxidants, and elevated lipid peroxidation indices in liver. Crocin treatment significantly reduced elevated markers of liver tissue injury and malondialdehyde , and brought back the liver antioxidants and the over accumulation lipids in serum towards normal. Histopathology of the liver confirmed the changes induced by high fat diet and the heptoprotective effect of Crocin.

  Conclusions: Crocin exerts protective effects against hepatic steatosis in rats fed with high fat diet possibly through its antioxidant actions.

Masoomeh Parvizi, Seyed Fazlollah Mousavi, Khadijeh Mohammadi , Mohsen Arzanlou,
Volume 16, Issue 3 (autumn 2016)

Background & objectives: Streptococcus pneumoniae is  one of the major causes of vaccine - preventable diseases worldwide. Current pneumococcal vaccines consist of serotype specific capsular polysaccharide antigen and do not offer full clinical protection against pneumococcal diseases. Due to such limitations, a new generation of protein-based pneumococcal vaccines is being developed. The objective of this study was to determine the distribution of gens encoding five protein antigens including pneumococcal histidine triad D and E (phtD, phtE), rlr- regulated gene A (rrgA), Autolysin (lytA) and Pneumococcal surface protein C (pcpC) among pneumococcal isolates collected from nasopharyngeal specimens in healthy children.

Methods: A total of 43 pneumococcal isolates were collected from nasopharyngeal specimens of healthy children attending the kindergartens in Ardabil province. The strains were identified using optochin susceptibility and bile solubility testes and further confirmed by amplification of capsular polysaccharide A gene (cpsA). PCR was used for screening the presence of pcpC, phtD, phtE, rrgA and lytA genes.

Results: 81.4 % of isolates were found to contain at least one of the tested genes. lytA, pcpC, phtE, phtD and rrgA were detected in 70, 60, 39.5, 35 and 25.5 percent of isolates, respectively. The results showed that the genes were not distributed consistently among the isolates and for obtaining a full coverage pneumococcal vaccine, multiple choices of these antigens should be included.

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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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