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Showing 3 results for Mohajeri

Mahdi Chinifroush, Seraj Mohajeri, Babak Shirinzadeh,
Volume 8, Issue 3 (Autumn 2008)

Background & Objectives: Carcinoid tumor is the most common appendix tumor and its origin in from neuroendocrine cells. 80% of tumors are located in GI tract and the most common site of the tumor is appendix .This neoplasm is found in 0.3-0.5 percent of appendectomized samples. The mean age in diagnosis time is 30 years old and the neoplasm is more common in women. The aim of this study was to investigate the age and sex prevalence of carcinoid tumor in appendectomized patients.
Methods: This descriptive study was done on 5644 specimens in the Fatemi Hospital of Ardabil  for surveying of carcinoid tumor prevalence, on the basis of age & sex, from 2003-2007.
Results: In this study, the prevalence of carcinoid tumor was 0.19%, average involvement mean 33.6 years old (ST= 23.1) & the men diameter of tumor was 0.74 cm (ST= 0.37). The prevalence in women was 3 in 1000 and in men was 1.36 in 1000.All of the tumor located in the tail portion of appendix. The tumor can cause acute appendicitis by duct obstruction but mostly is discovered during pathologic examination accidentally, conclusion pathologic examination of appendix with sagital incision in all appendectomy cases is recommended.
Parviz Mohajeri , Babak Izadi , Mansour Rezai , Badie Falahi , Hosna Khademi , Roya Ebrahimi ,
Volume 11, Issue 1 (spring 2011)

  Background & Objectives: Nowadays, appearance of ESBL producing bacteria is medical problem in the treatment of infections. Uropathogenic Escherichia coli like many other bacteria can produce these types of enzymes. T he assessment of the ESBL production by clinical isolates is not done routinely in laboratories. The aim of this study was to determine the prevalence of ESBL producing E.coli and its antibiotic resistance pattern in Kermanshah.

  Methods: This cross - sectional study was done on 200 Uropathogenic E. coli strains isolated from people in Kermanshah. Sensitivity of isolates to different antibiotics was determined by disk diffusion test and ESBL production was assessed by DDST method.

  Results: The E. coli strains showed high susceptibility to imipenem (100%), amikacin (97%), nitrofurantoin (95.5%), gentamicin (85%), cefepime (75%), ceftazidime (74%), ofloxacin (73.5%), ciprofloxacin, ceftriaxone and aztreonam (71%) and cefotaxime (70%) respectively. The highest resistance was seen to ampicillin (77%), carbenicillin (76%), pipracillin (74%) and SXT (62.5% ). Resistance rate to third generation cephalosporins was 63-75%. Fifty seven isolates (27%) were ESBL producers and 47 isolates (87%) produced all four types of ESBL enzymes.

  Conclusion: There are some similarities and differences in the antibiotic resistance pattern and ESBL production among the isolates in different areas of Iran and other countries. Identification of ESBL producing bacteria and determining its antimicrobial resistance pattern are recommended to effective treatment of infections.

Darioush Mohajeri , Ali Rezaie , Ghafour Mousavi, Mohammad Mazani, Adel Rezaei-Moghadam,
Volume 12, Issue 2 (summer 2012)

  Background & Objectives: The aim of the present study was to evaluate the protective effects of Crocin on rat high fat diet-induced hepatic steatosis model.

  Methods: For this purpose, male rats were given either standard diet as control, high fat diet for induction of hepatic steatosis and high fat diet plus Crocin through gavage at different doses (25, 50 and 100 mg kg-1/day) for protection of liver steatosis, at a period of 4 weeks in different experimental groups and compared considering serum lipid profile, serum biomarkers of liver tissue injury, hepatic antioxidant activity and liver histopathological changes. The serum levels of triglyceride, total cholesterol, low-density lipoprotein, very low-density lipoprotein, high-density lipoprotein for determination of deleterious metabolic effects, alanine aminotransferase, aspartate aminotransferase for determination of hepatocyte injury, alkaline phosphatase, bilirubin for assessment of biliary function, malondialdehyde and reduced glutathione content for assessment of liver free radical activity, the enzymatic activities of glutathione peroxidase, superoxide dismutase and catalase as indicators of antioxidation in liver tissue, were measured. Finally, the biochemical findings were matched with histopathological verifications.

  Results: After 4 weeks, high fat diet caused deleterious metabolic effects, including hypertriglyceridemia, hypercholesterolemia and liver dysfunction. Rats fed high fat diet alone showed increased activities of hepatocellular enzymes in plasma, significant decline in antioxidants, and elevated lipid peroxidation indices in liver. Crocin treatment significantly reduced elevated markers of liver tissue injury and malondialdehyde , and brought back the liver antioxidants and the over accumulation lipids in serum towards normal. Histopathology of the liver confirmed the changes induced by high fat diet and the heptoprotective effect of Crocin.

  Conclusions: Crocin exerts protective effects against hepatic steatosis in rats fed with high fat diet possibly through its antioxidant actions.

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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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