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Showing 3 results for Mirzaei

Hamid Mirzaei , Soltanali Mahboob , Karim Kazeman Alanag , Gity Karim ,
Volume 6, Issue 4 (Winter 2006)

  Background & Objectives: Salmonella is amongst the most important food-borne pathogens and s .typhimurium is the most common species causing food infection. L. casei, B. bifidum and B. angulatum are among probiotics with siginificant benefical effects in consumers. The purpose of this study was to investigate the interaction of the mentioned probiotics with s .typhimurium in vitro and growth in synthetic peptone water medium to evaluate the provisional effects of probiotic consumption in prevention and treatment of s .typhimurium food infection in humans.

  Methods: In order to activate the lyophilized bacteria, they were inoculated in erlene meyer containing peptone water and incubated at 37 °C for 24 hours. The activated probiotics and s .typhimurium were then incubated separately and together in peptone water medium for 24 hours at 37 ° c. Then, the number of their probiotic bacteria and S.typhimurium were counted in MRS and BGA media using surface plate method. This procedure was repeated 10 times for each experiment and a mean number of s .typhimurium in each ml of erlene meyer containing s .typhimurium alone and with probiotics and also the mean number of probiotic bacteria in each ml of erlene meyer containing probiotic alone and with salmonella were compared using independent t-test.

  Results: Co-cultural growth of L.casei and B.angulatum significantly inhibits s .typhimurium growth (P<0.05) but the inhibitory effect of B.bifidum was not meaningful and the co-culture of S.typhimurium had no meaningful effect on the growth of the above bacteria.

  Conclusions: Consumption of products containing L.casei and B.angulatum could have benefical effects in prevention and treatment of S.typhimurium infection although more in vivo researches should be carried out in this regard.

Hmid Mirzaei, Soltanali Mahboob , Bahram Amooghli Tabrizi , Mehran Mesgari Abbasi , Mohammad Manafi ,
Volume 8, Issue 2 (Summer 2008)

  Background & Objective: Hyperlipidemia is one of the main causes of cardiovascular diseases which have a high mortality throughout the world. Consumption of products containing specific strains of microbes as probiotics, produces positive effects in the host by balancing the flora of the digestive system. L.casei is a probiotic and the aim of this study was to evaluate the effects of consumption of milk containing L.casei on serum lipid profile of rats fed high lipid diet.

  Methods : This was an experimental study in which 30 male albino wistar rats with a body weight of 200 ± 15 gr were randomly allocated to two groups of treatment and control each containing 15 rats and adapted to a high lipid diet (11.47%) and water containing milk (25%). Rats in both groups received high lipid diet and water containing 25% milk for 48 days with the difference that rats in the treatment group received water containing L.casei considering that water consumption is created throughout the experiment, the amount of L.casei added to milk was calculated to each rat consumed 109 CFU bacteria per day.

  Results : Independent t-test revealed that at a level of α= 0/05 mean levels of total cholesterol and LDL-C of rats in the treatment group was significantly lower than that of control group (p<0/05), but the mean levels of triglyceride, HDL-C and VLDL-C was not significant. Also increase in body weight was significantly higher in the treatment group compared to the control group (p<0/01).

  Conclusion : Long term daily consumption of milk containing L.casei improve serum lipid profile by lowering total cholesterol level and also increase the rate of body growth.

Hamidreza Dehghan , Masoud Mirzaei , Ebrahim Mirzaei , Eslam Moradei Asl , Amin Ataiy , Mahbobeh Mirzaei ,
Volume 18, Issue 1 (spring 2018)

Background & objectives: Type 2 diabetes mellitus (DM) is a metabolic disorder that is common throughout the world. Meta-analysis is a statistical technique in which the results of two or more independent studies, with similar objectives, are mathematically combined in order to improve the reliability of the results. The aim of this study was to compare the efficacy of metformin and linagliptin in patients with type 2 diabetes.
Methods: To identify relevant studies, PubMed, ISI Web of Science, Embase, Cochran library, Scopus and Ovid databases were searched from January 2000 to August 2016. Mean difference (MD) with 95% confidence interval (CI) for efficacy were calculated and pooled analysis was performed using Stata V.12 and RevMan V.5.3 software.
Results: Four studies recruiting1260 patients with DM (682 patients in group linagliptin and 578 patients in metformin group) were included in this study. The MD of HbA1C outcome of 0.5 mg linagliptin was effective (0. 7295, % CI = 0. 69 - 0. 75). The MD of fasting blood sugar (FBS) test revealed that linagliptin was effective at 0.5mg (MD = 36.79, 95% CI = 35.20 - 38.38) and 5 mg (MD = 12.65, 95% CI = 2.68 to 22.63) doses.
Conclusion: Our results suggest that some doses of linagliptin versus metformin may be an effective treatment for DM2. However, the number of studies was limited, and further research is needed.

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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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