[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Contact us::
Site Facilities::
Indexing & Abstracting::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Creative commons

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

:: Search published articles ::
Showing 2 results for Mehdizadeh

Gholamhosein Farjah , Tahmineh Peirouvi, Mohammadtaghi Joghataei , Mahdi Mehdizadeh,
Volume 7, Issue 3 (Autumn 2007)

  Background & Objectives: Formation of myelin depends on maturation and development of the axonal cytoskeleton andmitochondria. Collagen gel can specifically play role in the regulation and development of axonal cytoskeleton.

  Methods: This research is an experimental study in which forty eight male rats (200-250g) were used. After axotomy, 1 cm segment of the sciatic nerve in rats was removed, and the gap was then bridged by one of the four following methods: polyvinylidene fluoride or PVDF + Collagen gel, Autograft, sham and control. Sciatic nerve was studied by electron microscope by the end of the 4th week and the 12th week.

  Results: By the end of the 4th week after the regeneration the number of unmyelinated axons in autograft and Collagen Gel was not significant, by the end of the 12th week, the number of unmyelinated axons in autograft group was superior to that of nerve growth factor group (P<0.01). After 12 weeks of regeneration, microtubular density values of normal and autograft groups were not statistically different. The cristae of axonal mitochondria in experimental groups are orientate parallel with its long dimension.

  Conclusion: The results of study indicated that because of its positive effect on the growth and development of microtubules and mitochodria, collagen Gel combination with PVDF can be used to repair peripheral nerve injuries.

Sahar Jafari, Alireza Mehdizadeh , Saeid Ghavamzadeh,
Volume 16, Issue 2 (summer 2016)

Background & objectives: Type 2 diabetes is a metabolic disorder considered as one of the most common chronic diseases in many countries, including Iran. One of the reducing factors in insulin sensitivity is increased serum levels of inflammatory factors like hsCRP and TNF-α. On the other hand, in recent years, Cuminum Cyminum is known as one of the potent herbs in the treatment of diabetes type 2 in animal studies. The aim of this study was to evaluate the effect of two doses of 50 and 100 mg of Cuminum Cyminum extract on glycemic indices and indicators of inflammation in human subjects with type 2 diabetes mellitus.

Methods: This study is a double blind randomized clinical trial performed in Urmia city on 2015. Samples were selected based on inclusion criteria and randomly divided into 3 groups: two groups receiving Cuminum Cyminum extract of 50 and 100 mg per day and the control (placebo) group. Before and 8 weeks after intervention, fasting blood sugar, serum insulin and inflammatory profile of hsCRP and TNF-α were measured. Data were analyzed by SPSS and the effect of supplementation was studied.

Results: The mean age of the all participants was 47.33±6.36. Results showed that the mean fasting blood sugar (FBS), glycosylated hemoglobin (HbA1c), and serum insulin reduced significantly in the both groups receiving Cuminum extract of  50 and 100 mg(p<0.01)., but increased in the placebo group. Average hsCRP and TNF-α levels have shown significant reduction at the beginning and end of the study in either group receiving 50 and 100 mg of supplementation (p<0.01).

Conclusion: This study indicates that short-term daily supplementation of Cuminum Cyminum extract at the doses of 50 or 100mg in patients with type 2 diabetes during 8 weeks may act to reduce the serum levels of insulin, blood glucose, glycosylated hemoglobin and hsCRP and TNF-α levels, and also may be fruitful for control of this disease.

Page 1 from 1     

مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
Persian site map - English site map - Created in 0.13 seconds with 30 queries by YEKTAWEB 4122