[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Contact us::
Site Facilities::
Indexing & Abstracting::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Creative commons

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

:: Search published articles ::
Showing 1 results for Khajouee Ravari

Shima Khajouee Ravari , Behzad Baradaran,
Volume 16, Issue 2 (summer 2016)

Background & objectives: Prostate cancer is one of the main reasons of death between men. Although there are many methods for treatment of this cancer but most of the patients still are died of the postoperative recurrence and metastasis of disease. Over expression of HMGA2 gene was observed in many human malignancies such as colorectal cancer, thyroid, pancreatic carcinoma and lung cancers. The aim of this study was to investigate the effect of HMGA2 specific small interfering RNAs (siRNAs) on viability and apoptosis in PC3 prostate adenocarcinoma cell line. 

Methods: siRNA transfection was performed with liposome approach. The cytotoxic effects of siRNA were determined using MTT assay on the PC3 cells and apoptosis was quantified using TUNEL assay.

Results: Transfection with siRNA significantly suppressed the expression of HMGA2 gene in dose dependent manner after 48 hours resulting in spontaneous apoptosis. Moreover, siRNA transfection had effects on prostate cancer cells viability.

Conclusion: Our results suggest that the HMGA2 specific siRNA effectively decreases prostate cancer cells viability and induces apoptosis in this cell line. Therefore it can be considered as a potent adjuvant in prostate cancer therapy.

Page 1 from 1     

مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
Persian site map - English site map - Created in 0.12 seconds with 29 queries by YEKTAWEB 4122