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Showing 7 results for Ghobadi
Amir Mohammad Asnaashari , Hasan Ghobadi Moralou, Shahrzad Mohamadzadeh Lari , Elham Ghalenoei ,
Volume 10, Issue 3 (autumn 2010)
The OHS is characterized by hypersomnolence, hypoxia, polycytemia, headache and edema. Polysomnography is the gold standard diagnostic test. Overnight oximetry with significant oxyhemoglobin desaturation is reasonable to begin treatment. Weight reduction and Non invasive positive pressure ventilation (NIPPV) has evolved as the mainstay of treatment.
Obesity is a risk factor for deep vein thrombosis (DVT). Heparin and warfarin are the drugs that used for treatment of DVT. HIT typically appears as a 50% or greater reduction in the platelet count after the first exposure to heparin. This case is a obese man with extreme DVT that diagnosed by duplex sonography and symptoms of obesity hypoventilation syndrom.
In overnight pulseoximetry oxyhemoglobin desaturation was occurred more than 15 times per hours and treatment begins with NIPPV. Patients thrombosis were treated with heparin and warfarin. Heparin induced thrombocytopenia (HIT) and cutaneous necrosis was occurred and drug therapy withdrawn. After healing of cutaneous necrosis low dose warfarin was started.
NIPPV promote airway occlusion and improve hypercapnia.hypoxia and quality of life and reduced cardiovascular complications.
Hasan Ghobadi, Afshan Sharghi , Jila Sadat-Kermani,
Volume 13, Issue 2 (summer 2013)
Background & Objective: Lung cancer is one of the most common cancers in the world and is considered as one of the top five cancers in Iran. The aim of this study was to evaluate the epidemiology and risk factors for lung cancer in Ardabil.
Methods: This cross-sectional study was done in Ardabil province since May 2009 to May 2011. Subjects were evaluated from two sources the first group was selected from patients of the Imam Khomeini hospital of Ardabil. These patients were underwent bronchoscopic biopsy in this center and their pathological reports were positive for primary lung cancer. The second group included the patients were reported in Ardabil cancer registry center with diagnosis of primary lung cancer and their samples have been sent to the other centers for analysis. We collected the data in a data sheet for each group separately and analyzed through the use of SPSS (ver. 16) statistical package.
Results: A total of 124 patients with lung cancer enrolled in this study (79% in the first group and 21% in second group). The male gender was dominant among the patients (82.3%) and the mean age of 64.23±9.99 years. In the first group more than half of the patients (54.1%) were urban, 90.8% had a history of smoking (mean 38.67±25.70 packs of cigarettes per year) and the history of opium abuse was high among subjects (34.7%), the positive family history of cancer was 17.3%, and the most common chief complaint at the time of diagnosis was bloody sputum (32.7%). Right upper lobe was the most common site of cancer in bronchoscopy of this group (27.64%) and squamous cell carcinoma was the most common form of malignancy (61.3%).
Conclusions: This study showed that unlike developed countries and in line with domestic studies, squamous cell carcinoma was the most common lung cancer, and adenocarcinoma was less common. Lung cancer among the men was seen 4.6 times more than women, and smoking was the most important risk factor.
Yousef Mohammadi Kebar, Elham Nejadseyfi , Hasan Ghobadi , Firouz Amani ,
Volume 14, Issue 4 (winter 2014)
Background & objectives: Procalcitonin (PCT) is a precursor of calcitonin hormone, comprising 116 amino acids, which is produced in thyroid neuroendocrine cells. However, in conditions such as septic shock, metastatic cancers, bacterial and fungal infections PCT is secreted by lung neuroendocrine cells, liver cells, and leukocytes. PCT is involved in acute phase of inflammatory process as a reactant protein. Hence, in this study serum and pleural fluid PCT was evaluated in common types of pleural effusion.
Methods: This is a cross-sectional case-series study carried out on 60 patients with pleural effusion. In this study, effusion cases due to tuberculosis, malignancy, effusion followed by pneumonia, and also transudate were investigated. Other cases of pleural effusion were excluded from this study. After collecting the samples, PCT levels in pleural fluid and serum of patients were measured and compared statistically with respect to the primary etiology of effusion.
Results: Sixty patients (10 patients with TB, 10 patients with malignancy, 10 patients with para-pneumonic, and 30 patients with transudative pleural effusion) participated in this study in which 61.7% were men and 38.3% women (p=0.204). The mean age of participants was 62.68 ±19.38 years. Results showed that mean of PCT in pleural fluid of patients with exudative effusion was 0.74 ng/ml (0.63 ng/ml in malignancy, 0.42 ng/ml in TB and 1.51 ng/ml in para-pneumonic) and in patients with transudative was 0.42 ng/ml. In addition, mean of PCT in the serum of patients with exudative pleural effusion was 0.74 ng/ml (0.65 ng/ml in malignancy, 0.40 ng/ml in TB and 1.20 ng/ml in para-pneumonic) and in patients with transudative was 0.43 ng/ml. The analyzed data showed that there was a significant difference in the pleural fluid (p=0.016) and serum PCT (p=0.009) of patients with pleural effusion transudate and exudates. After excluding patients with transudative, a significant difference was also observed among patients with exudative in such a way that in the para-pneumonic group the amount of PCT level in the serum and pleural fluid was more than tuberculosis and malignancy groups.
Conclusion: Serum and pleural fluid PCT is increased as a marker in response to inflammation. Although its increase in patients with bacterial and pneumonia infection is significant, it can be increased in patients with secondary inflammation of tuberculosis or malignancy and consequently can be used as an inflammatory indicator in the evaluation of patients with pleural effusion.
Hasan Ghobadi , Nasrin Mehrnoush , Gholamreza Hamidkholgh, Firouz Amani ,
Volume 14, Issue 4 (winter 2014)
Background & objectives: Today, the concept of q uality of services is particularly important in health care and customer satisfaction can be defined by comparing the expectations of the services with perception of provided services. The aim of this study was to evaluate the quality of services provided for outpatients in clinic of Ardebil city based on the SERVQUAL model.
Methods: This descriptive study was conducted on 650 patients referred to outpatient clinic since July to September 201 3 using a standardized SERVQUAL questionnaire (1988 ) with confirmed reliability and validity. The paired t-test and Friedman test were used for analysis of data by SPSS software.
Results: 56.1 % of respondents were male and 43.9 % of them were female . The mean age of patients was 33 ± 11.91 , 68.9 % of patients were in Ardabil and 27.3 % of them had bachelor's or higher. The results showed that there is a significant difference between perceptions and expectations of the patients about five dimensions of the service quality (tangibility, reliability, assurance, responsiveness, and empathy) in the studied clinic (P< 0.001). The highest mean gap and minimum gap were related to empathy and assurance, respectively.
Conclusion: Regarding to observed differences in quality , the managers and also planners have to evaluate their performance more accurately in order to have better planning for future actions. In fact, any efforts to reduce the gap between expectation and perception of patients result in greater satisfaction, loyalty and further visits to organizations.
Rana Keyhanmanesh, Mohammad Reza Alipour, Hasan Ghobadi, Mahdi Ahmadi, Alireza Moradi, Mohammadreza Aslani,
Volume 18, Issue 4 (winter 2019)
Background & objectives: Epidemiological and clinical studies have shown a close relationship between asthma and obesity. The present study examined the effect of obesity on the airway response to methacholine and the number of inflammatory cells in the bronchoalveolar fluid of ovalbumin-sensitized male rats.
Methods: Twenty-four male Wistar rats were divided into 4 groups: normal diet (C+ND), OVA‐sensitized with the normal diet (S+ND), high-fat diet (C+HFD) and OVA‐sensitized with high‐fat diet (S+HFD). All animals were fed for 8 weeks with standard diet or high-fat diet, and then were sensitized with ovalbumin or normal saline for another 4 weeks while receiving the designed regimens. At the end of the study, the number of inflammatory cells in bronchoalveolar fluid (BALF) and tracheal responsiveness to methacholine were examined.
Results: In diet-induced obesity groups, weight and obesity indices increased (p<0.05 to p<0.001). The results also showed that tracheal responsiveness to methacholine in S+HFD group compared to S+ND group, was significantly increased (p<0.05). In addition, the number of inflammatory cells in the BAL, in the S+HFD group was higher than other groups (p<0.001).
Conclusion: the results of this study suggest that the response of the airways to methacholine and the number of inflammatory cells are increased in obese-asthmatic male rats.
Mohammad-Reza Aslani, Elham Gholizadeh, Hadi Ghobadi, Afshan Sharghi, Hassan Ghobadi,
Volume 19, Issue 1 (spring 2019)
Background & objectives: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and systemic inflammation which is also associated with pulmonary and extra-pulmonary complications. COPD Diagnostic Questionnaire (CDQ) is a valid questionnaire that is used to identify patients with COPD. The purpose of this study was to determine the relationship between the severity of airflow limitation and the CDQ score in COPD patients.
Methods: In this study, 100 patients with COPD and smoking history were included. The diagnosis of COPD was established based on American Thoracic Society (ATS) guidelines: cough and expulsion of phlegm, chronic dyspnea, obstructive spirometric pattern (forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) <70%). Disease severity was classified according to GOLD criteria. After obtaining consent, demographic data, history of smoking, the exacerbation rate in the past year, arterial oxygen saturation (Spo2) and spirometer variables were recorded. Then, CDQ and Modified Medical Research Council (MMRC) dyspnea score were completed. Also, the associations of the CDQ score with FEV1% predicted and clinical parameters of patients were tested.
Results: All studied patients were male. There was a significant relationship between CDQ score with FEV1% (p<0.001), GOLD stage (p<0.01), Spo2 (p<0.01), exacerbation rate (p<0.01) and severity of dyspnea according to MMRC dyspnea scale (p<0.01).
Conclusion: The CDQ can be used to determine airflow limitation, severity of dyspnea and exacerbation rate in COPD patients. Therefore, it is recommended that this questionnaire can be used in primary health centers for identifying and referring of COPD patients.
Hasan Ghobadi, Somaieh Matin, Ali Nemati, Hasan Javadi , Reza Alipanah-Moghadam , Mehdi Saeidi-Nir ,
Volume 19, Issue 1 (spring 2019)
Background & objectives: Chronic Obstructive Pulmonary Disease (COPD) is accompanied by systemic inflammations and is characterized by irreversible airflow limitations. Leptin is a cytokine with pre-inflammatory effect. However, there have been no studies on the effect of conjugated linoleic acid (CLA) on the serum leptin concentration in COPD patients. Therefore, the present study aimed to explore the effect of CLA on the serum leptin level, lung function and quality of life in COPD patients.
Methods: This interventional study was conducted on 90 COPD patients. The patients were randomly divided into two groups (supplement and placebo) with 45 patients per group. After obtaining written consent from the patients and recording their demographic characteristics, the spirometry was performed and COPD assessment test (CAT) score was calculated. Moreover, a fasting blood sample was collected from each of them in order to analyze their serum leptin concentration. After that, the patients in the supplement group were administered with 3.2 g/day of CLA for 6 weeks. The patients in another group received placebo. After the intervention, spirometry, CAT score calculation and blood sampling were repeated for all of the patients and the obtained results were analyzed.
Results: after the intervention, a significant decrease both in the serum leptin level and in CAT score as a quality life marker was observed in the supplement group (p<0.05). Moreover, the FEV1 levels as a lung function test, increased significantly in the supplement group after the intervention (p<0.05). Although, the difference between the two groups was not significant.
Conclusion: The use of CLA supplement can improve COPD patients’ quality of life through decreasing the serum level of leptin in their blood.