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Showing 5 results for Ghannadi

Mahdi Farhoudi , Mohammadkazem Tarzamani , Khandan Ghannadi Emami ,
Volume 6, Issue 2 (Summer 2006)
Abstract

  Background & Objectives: Cerebrovascular diseases are the most common disabiling neurologic disorders and the third cause of death in the population over 45 years of age. Most of the strokes in adults are ischemic and almost one-fifth of them are due to intra- or extracranial internal carotid artery stenosis. Ultrasonography is a noninvasive, cost-effective and safe technique for evaluation of intra or extracranial vessels that is available in two methods: TCD and carotid Duplex. The present research is an attempt to investigate the appropriatens and comprehensiveness of TCD in diagnosing symptomatic significant carotid stenosis.

  Methods : This descriptive-analytical study was conducted on fifty patients admitted to the neurology ward of Imam Hospital who underwent both carotid duplex and TCD examination. Variables of blood flow velocities, collateral flow evidences and degree of carotid stenosis were assessed with both methods. The data were analyzed by SPSS (ver.11.5) using T.test, Chi-square and Fisher test.

  Results : 34 patieuts were. Male mean age of the patients was 66.70% of the subjects were above 65 and 68% of them had a history of hypertension. No statistically significant difference was seen between systolic and diatolic blood flow velocity in internal carotid artery and pulsatile index obtnined from reported by TCD and carotid Duplex. There was no statistically significant difference between the percentage of stenosis TCD finding of the patients with carotid stenosis showed collateral flow in 78.57% of the cases.

  Conclusion: Acceptable correlation of the flow velocity parameters and the percentage of carotid stenosis between TCD and Carotid Duplex results showed that the primary performance of TCD to diagnose significant carotid stenosis (that causes hemodynamic disorder) and screen ischemic cerebrovascular accident is a reliable and effective method, but for precise determination of stenosis, plaque typing and for diagnosing stenisis below 50% the performance of carotid duplex study is also necessary and to complemantory TCD.


Manoochehr Iranparvar, Fathemeh Ghannadi-Asl,
Volume 9, Issue 3 (autumn 2009)
Abstract

  Background & Objectives: Adherence to a diabetic diet is one of the most important aspects of diabetes management. Compliance with a diabetic diet has usually been described in terms of total intake. We examined indexes of the use of specific foods that would normally be either recommended or prohibited by Food Frequency Questionnaire.

  Methods: In order to study the dietary habits of the patients with type II diabetes 228 outpatients with type II diabetes referring to Ardabil Diabetic Clinic were randomly selected.

  Results : A common diabetic diet was reported by 87.8% of women (N = 115) and 77.1 % of men (N = 74). The dietary habits of the patients showed their awareness of limiting use of simple sugars. Use of foods with high simple sugars (e.g.: honey, jam, soft drink) were low among the patients. Potato was consumed by 58.8% of the female and 74.2% of the male, and of 43.8% of the subjects used mulberry with tea.

  Conclusions: Our result showed that there should be a greater focus on counseling, education and improving dietary of patients with diabetes.


Kamal Yavari , Mohammad Ghannadi,
Volume 12, Issue 2 (summer 2012)
Abstract

  Background & Objectives: The monoclonal antibody cetuximab binds to EGFR and thus provides an opportunity to create both imaging and therapeutic modalities that target this receptor. The potential of cetuximab as a radioimmunoconjugate was investigated and quality control tests (in vitro and in vivo) were performed as a first step in the production of a new radiopharmaceutical.

  Methods : Cetuximab solution was dialyzed and concentrated using an Amicon Ultra-15 filter. Purified antibody was labeled with lutetium-177 using the acyclic bifunctional chelator, DOTA-NHS, and radioimmunoconjugates were purified by PD10 columns. Radiochemical purity and stability in buffer and human blood serum were determined using thin layer chromatography. Integrity of the radiolabeled complex was checked by SDS-PAGE. Preliminary biodistribution studies in normal mice model performed to determine radioimmunoconjugates distribution up to 72h.

  Results: The radiochemical purity of the complex was 98±1%. The stabilities in phosphate buffer and in human blood serum at 96 hours post-preparation were 96±2 % and 78±4%, respectively. All of the samples, controls and radiolabeled antibodies, showed a similar pattern of migration in the gel electrophoresis. Biodistribution of Lu177-cetuximab was evaluated in normal mice and the highest ID/g% was observed in the blood (13.2±1.3% at 24 hours) and the liver (9.1±1.3% at 24 hours).

  Conclusion: Our results show that DOTA-cituximab can be labeled with 177Lu. Lu177-cetuximab has sufficient stability and retains its integrity. The new complex could be considered for further evaluation in animals and possibly in humans as a new radiopharmaceutical for use in radioimmunotherapy of cancers.


Fatemeh Ghannadiasl , Reza Mahdavi,
Volume 16, Issue 2 (summer 2016)
Abstract

Background & Objectives: Obesity is associated with metabolic abnormalities such as insulin resistance. Weight loss is always recommended for meaningful reduction in these abnormalities. Therefore, we examined the effects of balanced low calorie diet on weight loss, fasting insulin and insulin resistance in obese women attending the nutrition clinic.

Methods: In this clinical trial, forty five volunteer apparently healthy obese women (body mass index: 33.28 ± 2.90 kg/m2 and age: 28.40 ± 7.98 years) were recruited from the nutrition clinic in their first visit. The participants were received a balanced low calorie diet over 6 months after anthropometry measurement and blood sampling for determination of fasting insulin and insulin resistance level. Balanced low calorie diet was an individualized diet with an energy deficit of 500 calories of daily energy intake that was calculated from 3-day food records for every person. At 6 months after intervention, continuous and dichotomous variables were assessed using paired t-test and McNemar test, respectively.

Results: The mean recommended energy intake was 2241.78 ± 219.02(kcal). After 6 months, there were significant reductions in body weight (p=0.003), body mass index (p=0.005), waist and hip circumferences (p<0.001 and p<0.001, respectively). There was also significant improvement in fasting insulin level (13.47 ± 6.55 vs. 11.95 ± 4.17 µU/ml, p=0.01). Whereas, insulin resistance had not significant reduction (p=0.1).

Conclusion: In obese women attending the nutrition clinic, the balanced low calorie diet resulted in weight loss and improvement in fasting insulin. These positive changes can help to decrease the risk factor profile in obese individuals.


Fatemeh Ghannadiasl,
Volume 18, Issue 3 (autumn 2018)
Abstract

 
Background & objectives: The aim of the present study was to evaluate 8 weeks individualized balanced low calorie diet on anthropometric measurements in apparently healthy obese women.
Methods: Forty apparently healthy obese women (age: 18-40 years and 27.5≤BMI≤40 kg/m2) were recruited from the nutrition clinic in Ardabil city. The participants received a balanced low calorie diet after anthropometric measurements. Paired T-test was used to compare the changes during 8 - week intervention.
Results: Individualized balanced low calorie diet resulted in a significant decrease in body weight (-3.99±0.34 kg, p<0.001), body mass index (-1.61±0.14 kg/m2, p<0.001), waist circumference (-2.91±0.32 cm, p<0.001), hip circumference (-1.89±0.37 cm, p<0.001), waist to hip ratio (-0.01±0.004, p=0.001), waist to stature ratio (-0.02±0.002, p<0.001), body adiposity index (-0.97±0.15%, p<0.001), abdominal volume index (-1.07±0.11, p<0.001) and conicity index (-0.007±0.002, p=0.001) during 8 weeks.
Conclusion: Based on the results, an individualized balanced low calorie diet induced weight loss and decreased other anthropometric measurements during 8 weeks. Balanced low calorie diet-induced moderate weight loss alone can be a good way to reduce metabolic risk factors in obese women. .
 

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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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