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Showing 2 results for Faizi

Ali Nemati, Reza Mahdavi , Eiraj Faizi, Abbas Nagizadeh Baghi,
Volume 12, Issue 3 (autumn 2012)
Abstract

  Background & Objectives: Chemotherapeutics induce side effects in patients with cancer . In animal models the intake of ω3 fatty acids during chemotherapy can increase the impact of chemotherapy drugs and reduce their side effects . This study was aimed to determine the fish oilintake on side effects of chemotherapy drugs in patients with gastric cancer.

  Methods: A double blind clinical trial study on 30 adult volunteer patients (15 experiments and 15 controls) with gastric cancer was conducted during chemotherapy in Ardabil, Iran, during 2010-2011 . Experimental and control groups were selected by randomized allocation. About 3 grams ω-3 fatty acid supplementation (1.8 g Eicosapentaenoic acid & 1.2 g Docosapentaenoic acid ) and placebo were given to experimental and control groups for 6 weeks, respectively . Then, the results of data were collected at the beginning, 4 and 6 weeks after intervention of ω3/placebo in both groups and analyzed by using descriptive statistics , Chi -Square , Independent sample t-test and Cochran,s Q test.

  Results: The results of this study showed that there were significant differences of nausea in both group of patients at the end of 6 weeks (p<0.05). A bdominal cramp and nausea significant ly decreased in experimental group during the study (p<0.05). Hair loss , vomiting and diarrhea were reduced in experimental group during the study, but these differences were not statistically significant . There were no significant differences in vomiting , diarrhea and hair loss between two groups at the end of intervention.

  Conclusion: The present study showed that the intakes of fish oil strongly reduce side effects of chemotherapy drugs such as nausea and abdominal cramp. So, this oil supplementation appears to be harmless and useful in patients with gastric cancer during chemotherapy .


Iraj Faizi, Saeid Smaeilpour, Ali Nemati , Khatere Isazadeh, Farideh Faizi, Vahid Montazeri,
Volume 17, Issue 3 (autumn 2017)
Abstract

Background & objectives:  The use of supplements such as L-carnitine, optimum nutritional support and early feeding after surgery in cancer patients can be important in the prevention of cancer complications. The aim of this study was to determine the effects of early L-carnitine-rich feeding on complications of esophageal cancer surgery and duration of hospitalization.
Methods: In a clinical trial, 50 patients with esophageal cancer under surgery in two equal groups were randomly selected. Nutritional information was obtained using food record questionnaire. Basic blood samples and 24-hour urine samples were taken in order to measure the hematological parameters (like blood cell count, hemoglobin, hematocrit and blood urea) and nitrogen balance, respectively from two groups at the beginning and end of the study. Then, the intervention group received 3 g L-carnitine daily in 3 doses on the first day after the complementary operation, with a routine hospital diet at each meal, and the control group received a routine hospital diet for ten days. Data were analyzed using independent t-test, paired t-test and chi-square test.
Results: The results showed that changes in the mean BUN and nitrogen balance were significantly different after intervention between the study groups (p<0.05). Patients with early L-carnitine-rich feeding had less hospitalization time in hospital wards and were discharged earlier (p<0.05).
Conclusion:  The results of this study showed that early L-carnitine-rich feeding after surgery has probably a positive effect on the duration of hospital stay in patients with esophageal cancer.

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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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