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Showing 3 results for Eidi

Ali Mohammadian, Saeid Sadeghieh, Jaleh SaEidian,
Volume 9, Issue 1 (spring 2009)

  Background and objective: Injuries account for 16% of global burden of diseases and causes a great deal of mortality and morbidity. Today, amputation is one of the biggest challenges facing us and may accompany serious functional, psychosocial and personality disorders in communities. Therefore, we decided to assess the causes and types of traumatic amputation in patients referring Ardabil’s Fatemi Educational Hospital from 2005 through 2006.

  Methods and materials: The present study was descriptively & analytically) retrospective in which the data were collected using a questionnaire. Our study population included 218 cases referring Ardabil Fatima educational Hospital for amputation from the beginning of 2005 through the end of 2006.

  Results: In this study, the mean age of injured cases is 28.9±19.1 and men were also injured three times more than women. Most of the cases attended in summer between 8:00 Am -8:00 Pm. The number of cases among city dwellers and residents of rural areas were almost equal and most of the cases (39/6%) were illiterate. Most of the cases were injured outdoors especially in their workplace. The most commonly seen cause of amputation was tools used in farming and husbandry especially mower. Most of the amputations (50/5%) were total and unintentional (99.5%). Most of the injuries were seen in upper extremities (94.5%), hands and especially fingers (97%)

  conclusion: Based on the obtained results, male workers are at a higher risk. Most of the injuries occurred during the work hours and amputation caused by tools used in farming and husbandry has a high prevalence. This is probably due to the unsafe and old structure of these tools.

Savadali Saifi Novashnag , Shahrbanou Oryan , Akram Eidi, Parichehr Yaghmaei,
Volume 16, Issue 2 (summer 2016)

Background & objectives: PCOS is one of the most prevalent endocrinology disorders and 5-15% of women in fertility age suffer from this disease. The leptin a 167 amin oacid peptide is secreted from adipose tissue in a pulsatile fashion. This hormone is essential in regulation of normal body weight and like the klotho hormone that is expressed most prominently in the distal convoluted tubules of kidneys and the choroid plexus of brain, has a role in pathogenesis of reproductive disorders. The secreted klotho has been identified as an anti-aging and anticancer hormone. Metformin is an anti-hyperglycemic drug with anorexic properties that could influence the function of ovaries.

Methods: In this case-control study, 45 patients with PCOS who referred to the infertility center of Jahad-e-Daneshgahi in the city of Ardabil from March 2013 through March 2014, were selected in accordance with the NIH criteria. Moreover, 45 healthy women were also selected as the control group. BMIs were calculated by division of weight by square of height and insulin resistance index was calculated by HOMA-IR model. Leptin and klotho serum levels were measured using ELISA kit. In the case group the measurements were repeated after a one-month course of therapy with metformin. Data analysis performed by SPSS software using dependent and independent t-tests.

Results: PCOS patients showed significant improvements after receiving metformin for one month.
Patients’ weights showed some decline. Fasting plasma glucose levels and insulin resistance decreased significantly (p<0.01). Hormonal assays indicated significant decrease in leptin and insulin levels and rise in Klotho levels. BMIs did not change meaningfully. Measurements of leptin and klotho levels showed a decrease in mean leptin levels from 34.74 to 28.41 ng/l and the level of klotho increased from 4.01 to 5.43 ng/l.

Conclusion: This study showed that metformin treatment can cause a rise in klotho and a decrease in leptin levels without considerable effects on the weights of women with PCOS. Probably, leptin exerts its physiological effects in low concentrations while klotho in contrast acts physiologically in higher concentrations.

Hasan Ghobadi, Somaieh Matin, Ali Nemati, Hasan Javadi , Reza Alipanah-Moghadam , Mehdi SaEidi-Nir ,
Volume 19, Issue 1 (spring 2019)

Background & objectives: Chronic Obstructive Pulmonary Disease (COPD) is accompanied by systemic inflammations and is characterized by irreversible airflow limitations. Leptin is a cytokine with pre-inflammatory effect. However, there have been no studies on the effect of conjugated linoleic acid (CLA) on the serum leptin concentration in COPD patients. Therefore, the present study aimed to explore the effect of CLA on the serum leptin level, lung function and quality of life in COPD patients.
Methods: This interventional study was conducted on 90 COPD patients. The patients were randomly divided into two groups (supplement and placebo) with 45 patients per group. After obtaining written consent from the patients and recording their demographic characteristics, the spirometry was performed and COPD assessment test (CAT) score was calculated. Moreover, a fasting blood sample was collected from each of them in order to analyze their serum leptin concentration. After that, the patients in the supplement group were administered with 3.2 g/day of CLA for 6 weeks. The patients in another group received placebo. After the intervention, spirometry, CAT score calculation and blood sampling were repeated for all of the patients and the obtained results were analyzed.
Results: after the intervention, a significant decrease both in the serum leptin level and in CAT score as a quality life marker  was observed in the supplement group (p<0.05). Moreover, the FEV1 levels as a lung function test, increased significantly in the supplement group after the intervention (p<0.05). Although, the difference between the two groups was not significant.
Conclusion: The use of CLA supplement can improve COPD patients’ quality of life through decreasing the serum level of leptin in their blood.

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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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