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Showing 2 results for Davoodi

Jamshid Yousefi, Abdolreza Malek, Seyedmorteza Mirzadeh , Samaneh Davoodi ,
Volume 6, Issue 3 (Autumn 2006)
Abstract

 Background and Objectives: Jaundice is a common disorder in preterm and term newborns and G6PD deficiency is one of its etiologic agents. With respect to high incidence of G6PD deficiency in Iran, this study was conducted to determine the clinical correlation of this deficiency with time of jaundice onset and mean level of serum bilirubin. Management and complication rates are also evaluated in these neonates in comparison with those without this deficiency.

 Methods: This is a case-control study performed through G6PD assay in icteric newborns admitted to neonatal intensive care unit in 22 Bahman hospital in Mashhad within 3 years. This case group was compared with the control group who were randomly selected from among icteric neonates without G6PD deficiency. The data were collected by a questionnaire and analyzed by SPSS.

  Results: This study was done on 505 icteric neonates. The case group consisted of 34 newborns (6.7%) with G6PD deficiency. M/F ratio in case group was higher than control group (P= 0.01). Mean level of total serum bilirubin was significantly higher in case group (P=0.047). There were no significant differences in duration of phototherapy and hospitalization between two groups, but exchange transfusion rate in case group was twice as much. Complications such as seizure and kernicterus in both groups were the same.

 Conclusion: Due to high incidence of G6PD deficiency in our study (6.7%) and significant incidence in female patients, determination of enzyme level is recommended in all newborns with jaundice regardless of their gender. Because of higher level of serum bilirubin in G6PD deficient patients, phototherapy must be done as soon as possible to avoid invasive procedures such as exchange transfusion.


B Davoodi, Kh Onsory , M Heydari Nasrabadi,
Volume 15, Issue 2 (summer 2015)
Abstract

  Background & objectives : Ovarian cancer is the most common female reproductive cancer which is caused due to the malignant transformation of ovarian cells. This type of cancer is the fifth most common cancer among women and the primary cause of cancer deaths in the world. Axin2 gene is a tumor suppressor gene of the Axin family in WNT cycle which is essential for embryonic development. WNT proteins in this pathway have important intermediary role in cell messaging and in primary and secondary development of the embryo. Axin2 gene is activated as a negative feedback to prevent excessive proliferation of cells with simultaneous activation of WNT messaging. The aim of this study was to find the frequency of mutation in rs1133683 region of exon 5 in Axin2 gene and its relation with the risk of ovarian cancer.

  Methods : In this case-control study, 100 patients with ovarian cancer together with equal number of same age as controls were collected from Imam Khomeini Hospital. DNAs were extracted from blood and tissue and then were investigated by PCR-RFLP. Data analysis was performed using software SPSS (version 19) using logistic regression.

  Results : The results of study of mutation in rs1133683 region of exon 5 in Axin2 gene between two groups of case and controls indicated that there is no significant association between CT genotype with ovarian cancer (OR=1.26, 95%CI 0.70-2.27,p=0.43). Also no association was observed between TT genotype of Axin2 gene and ovarian cancer risk (OR=1.56, 95%CI 0.49-4.96, p=0.44).

  Conclusion : Study of mutation in rs1133683 region showed that there was no association between TT genotype carriers of Axin2 gene and the risk of ovarian cancer.



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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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