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Showing 2 results for Barari

Akbar Pirzadeh , Mirmehdi Chiniforush , Asghar Pirzadeh , Susan Barari ,
Volume 14, Issue 1 (spring 2014)

  Extramedullary plasmacytomas are rare solitary soft tissue tumors that arise from proliferations of malignant transformed monoclonal plasma cell. Though they are closely related to multiple myelomas, they have better prognosis. The tumor is eradicated by surgery or local radiation therapy. This is a case-report study of solitary plasmacytoma tumor which involved left side maxillary sinus and underwent excisional biopsy confirmed by IHC.

Hasan Delroz, Ahmad Abdi, Dr Alireza Barari, Parvin Farzanegi,
Volume 19, Issue 3 (atumn 2019)

Background & objectives: Non-alcoholic fatty liver disease (NAFLD) is associated with mitochondrial dysfunction. The aim of the present study was to examine the effect of aerobic training along with resveratrol on cardiac expression of OPA1 and DRP1 in NAFLD male rats.
Methods: In this experimental study, forty eight male Wistar rats were classified into two groups: NAFLD (n=40) and Control-Normal (CN), (n=8). NAFLD was induced in rats with high fat diet and then subdivided into five subgroups, including patient (NAFLD), sham (SHAM), exercise-patient (TRNAF), supplement-patient (SUPNAF) and exercise-supplement-patient (TRSUPNAF). Training groups performed a running program on a motor-driven treadmill for eight weeks. Resveratrol (20 mg/kg) was injected into the SUPNAF and TRSUPNAF groups. Forty eight hours after the last training session, rats were anesthetized; hearts were excised and immediately frozen in liquid nitrogen and stored at -80°C for measuring the indexes. Statistical analysis was performed using a one way analysis of variance, and Statistical significance was accepted at p≤ 0.05.
Result: The results indicated that the induction of NAFLD decreased OPA1 expression (p=0.001) and increased DRP1 expression (p=0.001) compared to CN. Also, in SUPNAFLD and TRSUPNAF groups, OPA1 (p=0.014 and p=0.001 respectively) increased and DRP1 (p=0.043 and p=0.007 respectively) decreased significantly compared to the NAFLD group.
Conclusion: It seems that exercise training and resveratrol alone or in combination by increasing OPA1 and decreasing DRP1 myocytes modulates heart damage in NAFLD patients.

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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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