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Showing 5 results for Babapour

Behzad Babapour , Ali Khaledi,
Volume 7, Issue 3 (Autumn 2007)

  Background & Objectives: Usually, among the candidate patients for cardiac valve's surgery, the coronary artery angiography is performed according to their age and gender. By this research, the prevalence of coronary artery disease is studied in addition we have tried to consider the risk - factors of coronary artery disease to predict the probability of coronary artery disease among them.

  Methods: we studied prospectively a population of 320 patients (144 male and 176 female) who were candidate to cardiac valve's surgery and underwent preoperative angiography in the cath - Lab of Imam Khomeini hospital in Tehran, from April - 1999 to October - 2003.

  Result: There was aortic valvulopathy in 131 patients, mitral in 90 and combined Mitro-aortic in 99. Angina was present in 35% and coronary artery disease risk factors in 27.8% of patients. The prevalence of coronary artery disease was 13.1 %. The prevalence of coronary artery disease in patients with angina was significantly higher (22.3% versus 8.2% in patients without angina). In addition the prevalence of coronary artery disease was significantly higher in patients with coronary artery disease risk factors (22.5% versus 9.5% in patients without risk factors). Three predictive factors of CAD in these patients were age, presence of angina pectoris and presence of CAD risk Factors. The prevalence of CAD in patients who have neither angina nor risk factors was 4.6%. In this group of patients no male under 60 years old and only 3.5% of female patients under 65 years old had coronary artery disease.

  Conclusion: The study showed that due to the low prevalence of coronary artery disease in patients with none of the coronary risk factors or without angina, we can avoid preoperative coronary angiography in males under 60 years old and females under 65 years old who have neither angina nor risk factors of CAD.

Adalat Hoseinian , Farhad Pourfarzi, Nasrin Sepahvand , Shahram Habibzadeh, Behzad Babapour , Hosein Doostkami , Nasrin Fouladi, Mehri Seyed Javadi ,
Volume 12, Issue 1 (spring 2012)

  Background & Objectives: Myocardial infarction is one of the most common causes of mortality throughout the world. Utilization of thrombolytic drugs at the first hours upon MI leads to decrease in the rate of mortality. Streptokinase (SK) is commonly used because of its cost and availability. The golden time for maximum effect of SK appeared to be first hours after MI. The drug efficiency diminishes after 3 hours and it will be ineffective after 12 hours.

  This study was aimed to investigate interval between onset of the clinical symptoms and streptokinase receiving in patients with acute myocardial infarctionadmitted for drug reception.

  Methods: This cross-sectional study was conducted in 150 patients with STEMI (ST elevation Myocardial Infarction ) who were attended to emergency room of Imam Khomeini hospital and fulfilled a questionnaire containing the data about age, sex, educational level, onset of symptoms, referring time to emergency room, SK utilization, past medical history of cardiac diseases, type and location of AMI, contraindications and side effects of SK.

  Results: In 111 men (74%) and 39 women (26%), the mean for interval between onset of symptoms and drug injection was 8 hour and 27 minutes ± 8 hour and 18 minutes .Only 41% of patients received streptokinase in less than 3 hours after chest pain. The main reasons for delaying in drug consumption were delayed decision to come to hospital in 61% of persons, long distance to hospital for 22% of individuals, delayed admission tor CCU for 13% of cases and delay in physician diagnosis for 0.043% of patients. To have a male sex and residency in city where the hospital was establilished were associated with less-delayed treatment start. However, the educational level, age and history of MI were not correlated with onset of treatment.

  Conclusions: Our results clearly show that the majority of patients receipt streptokinase more than 3 hours after chest pain. With considering the factors associated with delay to receive SK, teaching the patients with ischemic heart disease and giving information about golden time for thrombolytic therapy and its effect in prognosis as well as extending cardiac disease treatment centers in suburbs are recommended.

Behzad Babapour , Shahram Habibzadeh, Mehdi Samadzadeh, Bita Shahbazzadegan, Tahereh Mohammadi, Elham Atighi ,
Volume 12, Issue 5 (suppl 2012)

  Background & Objectives: Type 2 diabetes is a major cardiovascular risk factor such as HTN, HLP and smoking. A primary diabetic cardiomyopathy represents a high risk factor for heart failure in the absence of ischemic, valvular and hypertensive heart disease in the diabetic population. CAD is more common in diabetic patients and it is almost asymptomatic.

  Unquestionably, an early detection of LV damage and CAD is a major goal for the prevention of cardiac disease in the diabetic population.

  Methods: This study was done as Cross-Sectional method. The study sample consisted of 40 patients with type 2 diabetes mellitus without hypertension and cardiac symptoms (mean age 47 years) who recourse to diabetes clinic of Ardabil Imam Khomeini Hospital during 2009-2010. Left ventricular (LV) function was studied by echocardiography and exercise test using Bruce protocol. Data from the patients were collected and analyzed using SPSS 17 software.

  Results: All studied cases had a normal systolic function. 22 cases (55%) had diastolic dysfunction and 8 people (20%) had a positive stress test, which all had diastolic dysfunction too.

  Conclusion: This study showed that an impairment of left ventricular diastolic function occurs early in the natural history of diabetes mellitus and CAD is more common in diabetic patients with diastolic dysfunction.

Behzad Babapour , Shahram Habibzadeh , Alireza Mohammadzadeh , Nafiseh Mafi , Elham Atighi , Edalat Hoseinian , Bita Shahbazzadegan,
Volume 12, Issue 5 (suppl 2012)

  Background & Objectives: Low dose aspirin has been widely used in the prevention and treatment of cardiovascular disease. The bimodel action of aspirin on serum uric acid showed that aspirin at a high dosage promoted uricusuria while intermediate doses were (1-2gr/day) caused uric acid retention. The main goal of this study was to survey the effect of low dose aspirin on serum level of uric acid in patients with ischemic heart disease.

  Methods: The study design was cross-sectional and analytical type. In this study we selected 60 patients who used low dose aspirin among the patients of Imam Khomeini hospital's heart clinic (2008-9) and their information was registered in special questionnaires including serum level of uric acid and creatinine before and after prescription of aspirin. Data was then statistically analyzed using Paired t test and Willcoxon.

  Results: Of 60 patients 11 ( 18.3 % ) were under 50 years and 49 ( 81.7%) were above 50 years. The male to female ratio was 1.72 (38: 63.3% versus 22: 36.7%). 53.3 % of patients showed an increase in serum uric acid, but 46.7% did not. No significant differences in uric acid levels was found in patients under 50 years before and after administration of aspirin. Serum uric acid levels were increased after administration of 0.1unit of aspirin.

  Conclusion: Low -dose aspirin (80 mg/ day) caused a slight but significant increase in serum uric acid and creatinine levels in patients over 50 years of age.

Behzad Babapour, Farhad Pourfarzi, Mehdi Samadzadeh, Alireza Mohammadzadeh, Elham Atigi, Bita Shahbazzadegan,
Volume 13, Issue 3 (autumn 2013)

  Background & Objectives: Hypertension is one of the most important and common health problems in societies. Hypertension is often asymptomatic and can be simply treated. Many of drugs are available for treatment of hypertension i ncluding d iuretics, beta blockers, blockers of calcium channel, angiotensin-converting enzyme inhibitors, angiotensin receptor antagonists, alpha blockers and arterial dilators. This research was performed to evaluate the efficacy of some of these drugs on the hypertension. This may help to choose an appropriate medication for the treatment of stage 2 hypertension.

  Methods: A total of 150 patients with hypertension who were not under antihypertensive treatment and didn’t have contraindications for using hydrochlorothiazide , enalapril and atenolol were randomly allocated into three groups. These groups received atenolol 50 mg daily, hydrochlorothiazide 50 mg daily and enalapril 5 mg twice daily, respectively . After three weeks blood pressure of patients was measured and results were analyzed using SPSS.

  Results: Atenolol reduced systolic blood pressure (26.7±6.7 mm Hg 16.1%), diastolic blood pressure (10.3±1.2 mm Hg 10.4%) and mean arterial blood pressure (16.1±6.4 mm Hg 13.1%). Enalapril reduced systolic blood pressure (30.6±8.8 mm Hg 17.4%), diastolic blood pressure (11.5±4.4 mm Hg 11.4%) and mean arterial blood pressure (17.9±7.0 mm Hg 14.2%). Hydrochlorothiazide reduced systolic blood pressure (25.1±5.8 mm Hg 14.6%), diastolic blood pressure (9.2±2.3 mm Hg 9.3%) and mean arterial blood pressure (14.5±6.4 mm Hg 11.8%).

  Conclusion: Despite recommendations the use of hydrochlorothiazidein the treatment of hypertension, seems lower effect only use of this drug groups in comparison with other groups, and maybe add this category to other drugs and combined treatment is better than monotherapy with these groups .

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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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