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Showing 8 results for Babaei
Faride Golfooroshan, Effat Khodaeiani , Shahla Babaei Nejad , Delara Laghosi,
Volume 6, Issue 2 (Summer 2006)
Background & Objectives: Diabetes mellitus (DM) is a clinically and genitically heterogeneous group of disorders characterized by abnormally high levels of glucose in blood. The skin is involved both in the effects of acute metabolic changes and in the chronic degenerative compilications of diabetes. Skin lesions are frequently observed in diabetic patients and it is generally stated that about 30% of these patients have cutaneous disorders. The aim of this study was to assess the prevalence of skin lesion in patients with diabetes mellitus referring to dermatology and diabetes clinic of Sina hospital in Tabriz .
Methods: This descriptive-analytical study was conducted on diabetic patients with skin lesion who referr e d to diabetic and dermatology clinic of Sina hospital of Tabriz during 2003. Data collecting instrument was a questionnaire which included some variables such as age, sex, job, type of diabetes, its duration, control of blood glucose, receiving regular treatment, type of lesion. The questionnaire was filled out for each patient with skin lesion individally. Skin lesions due to burn were excluded from our study. The data were analyzed by SPSS using Chi-aquare and Fisher test.
Results : From a total of 500 patients, 80 patients (16%) had skin lesions. 57.5% of these patients was male and 91.2% had type II DM. Mean age of the patients with skin lesion was 56.86±1.54 years and mean diabetes duration was 10.87±0.82 years. Patients over 50 years had the most skin lesion . The most common type of skin lesion in the diabetic patients were 30 cases of necrotic ulcer (6%) and 22 cases of diabetic dermopathy (4.4%) respectively. Other skin lesions such as infection, sclerodermoid, punched out lesions, neuropathic ulcer, diabetic bulla, dermatitis and lichen planus were not common . 97.5% of diabetic patients with skin lesion had poor control of blood glucose. Twelve percent of the patients had some kind of diabetic foot ulcer (Neuropathic Necrotic, punched out and cellulitis ulcer altogether) of which 21.6% underwent amputation.
Conclusion: The results showed that rate of skin lesions in diabetic patients is decreased. compared to the past. This may be due to increase of knowledge and attitude of patients regarding diabetes and its complications.
Seyedeh Hooriyeh Fallah, Narges Kalantar, Seyedmahmood Mahdinia, Neda Taheri, Nooshin Babaei,
Volume 8, Issue 1 (Spring 2008)
Background & Objective: Iodine deficiency is one of the most important life-threatening factors from the beginning and encounter irreversible damage to human. This study aimed to investigate stability of Iodine in iodized salt in different situations such as light and humidity and comparing it with standard amounts.
Methods: In this cross-sectional descriptive-analytical study, 12 samples of iodized salts which have been distributed in Damghan, were accidentally selected. Samples were examined in the chemistry laboratory of Faculty of Health (Damghan University of Medical Sciences) using titration method recommended by British pharmacopeh. 10 mg of each iodized salts were kept at presence of light, darkness, humidity, and non- humidity situation and then titration method was performed. The samples were kept for two weeks and examined weekly. Data were analyzed with T paired and ANOVA tests using SPSS software.
Results: Findings of this study showed that reduction of Iodine was seen for all samples. The amount of reduction were 2.2, 1.5, 4.1 and 2.1 mg/l for purified salts at light, darkness, humidity, and non- humidity situation, respectively. The amount of reduction were 3.4, 2.1, 5.35 and 2.6 mg/l for non-purified salts at light, darkness, humidity, and non- humidity situation, respectively. In spite of reduction in Iodine, concentration of it was at standard amount (30-50 PPM).
Conclusion: Results showed that stability of iodine was more when salt was exposed to darkness in comparison with light situation (p< 0.09). Meanwhile, the stability of purified salts was more than the non- purified salts (p< 0.28). Also, stability of iodine was less at humidity in comparison with non- humid situation (p< 0.006). The purified salts which was exposed to humidity was much stable compared to the non- purified salts (p< 0.28). It also, demonstrated that the amount of iodine stability was more for salts which was exposed to light in comparison with humidity (p< 0.05).
Samira Babaeian , Mehranghiz Ebrahimi-Mameghani, Mitra Niafar , Sarvin Sanaii,
Volume 13, Issue 1 (spring 2013)
Background & objectives: Diabetes mellitus is one of the prevalent metabolic disorders in the world and mostly it is related to Obesity. Central obesity results in higher risk of diabetes, cardiovascular disease and hyperinsulinemia. Hyperinsulinemia is the main reason of central obesity disorders. Studies have been shown that the fruits, vegetables and drinks are rich in phenolic and antioxidants components may alleviate diabetes diseases. One of these fruits is pomegranate that is rich in flavonoids. Therefore, this study was designed to determine the effect of unsweetened pomegranate juice consumption on insulin resistance, inflammatory factor and anthropometric measures in diabetic patients.
Methods : In this clinical trial, 50 patients with type 2 diabetes aged 30-50 years were recruited into the study and randomly assigned into two groups: (1) intervention group (n=25) who drank 240 ml unsweetened pomegranate juice daily and (2) control group (n=25) who drank 240 ml water daily for two months. Fasting blood glucose, inflammatory factors including hs-CRP, anthropometric measures including weight, height, waist and hip circumference, BMI were determined at the baseline and after 8 weeks. Nutritionist IV program, Independent sample t-test, Paired sample t-test were used for data analyses.
Results : Comparison of fasting blood glucose, HbA1C, body mass index, hs-CRP between the two groups before intervention did not reveal a significant difference. The result of the study showed a significant decrease in insulin resistance, body weight, hip circumstance, waist circumstance in intervention group ( p <0.05 ، p <0.01 ، p <0.05 ، p <0.05 respectively) w hereas no significant changes were found for serum glucose, HbA1C, hs-CRP in this group .
Conclusion : These findings indicate the beneficial effect of the daily consumption of unsweetened pomegranate juice on insulin resistance, body weight, waist and hip circumstances.
Farnaz Seifi-Skishahr, Arsalan Damirchi , Manoochehr Farjaminezhad , Parvin Babaei ,
Volume 15, Issue 1 (spring 2015)
Background & objectives: The “redox” state represents the oxidation/reduction potential within the cell in a way that more “redox” is the marker of health, while the more oxidized reflects predisposition to diseases. Different types of exercise training may change the thiol/disulfide ratio of redox couples such as glutathione and represent a shift in redox balance. This study was assessed the influence of high-intensity aerobic exercise on glutathione redox state in red blood cells in professional, recreational athletes and nonathletes.
Methods: Ten voluntary well trained (WT), moderately trained (MT) and untrained men subjectswere randomly selected for this semi-experimental study (mean ages of 21.10±1.72 21.70±1.88 and 20.10±1.44, respectively). Blood samples were collected before, immediately, 10 min and 30 min after acute aerobic exercise with 75%VO2max. The levels of reduced glutathione (GSH), oxidized glutathione (GSSG) and (GSH/GSSG) in red blood cells (RBCs) as well as serum levels of cortisol and creatine kinase (CK) were measured.
Results: The results showed reduction, elevation and no changes in RBCs GSH/GSSG ratio in UT, MT and WT groups, respectively. The lowest levels of GSH/GSSG ratio in RBCs and the highest one were detected in the WT and MT groups, respectively. The serum levels of cortisol and creatine kinase were increased following the exercise in three groups.
Conclusion: It is concluded that acute aerobic exercise with high intensity does not change redox balance in well trained subjects, however it is capable to shift redox balance towards more reducing environment in moderately trained subjects and also to more oxidizing one in untrained subjects.
A Pourrahimghouroghchi, P Babaei, A Damirchi, B Soltanitehrani, S Ghorbanishirkoohi,
Volume 15, Issue 3 (autumn 2015)
� Background & objectives: Obesity and visceral fat accumulation after menopause are associated with lipid profile changes, metabolic syndrome and c ardiovascular diseases. The aim of this study was to investigate the effect of 8-week aerobic - resistance training and estrogen replacement therapy on visceral fat and cardiovascular risk factors in ov ariectomized rats.
� Methods: Fifty female Wistar rats were ov ariectomized and divided into 5 OVX groups (n=10 rats per group): Ovx+sedentary (Sedentary), aerobic - resistance training (Ovx+Exe), aerobic - resistance training+estrogen replacement therapy (Ovx+Exe+Est), estrogen replacement therapy (Ovx+Est) and vehicle group or sesame oil (Ovx+Oil). The exercise consisted of aerobic-resistance training (20 m/min, 3 days/week, 60 min/day, 10% slope, Load 3% body weight) 17b-estradiol valerate (30 �g/kg bw in 0.2 ml sesame oil) were injected subcutaneously three days a week during 8 week. The co-treatment group received both exercise and estradiol protocol as same as previous groups.
� Results: After 8-week of interventions, visceral fat signiﬁcantly reduced by Ovx+Exe and Ovx+Exe+Est compared to Sedentary rats (p<0.05), however no significant difference in body weight was observed. BMI signiﬁcantly reduced in Ovx+Exe and Ovx+Exe+Est groups compared to Sedentary group. Also, BMI signiﬁcantly reduced in Ovx+Est compared to Ovx+Oilgroup (p<0.05). Although this intervention changed lipid profiles, they were not statistically signiﬁcant in neither of groups. Statistical comparisons between groups were performed usingone-way ANOVA test followed by Tukey&rsquos post-hoc test. The differences were considered significant at p<0.05.
� Conclusion: Eight weeks aerobic-resistance training successfully decreases visceral fat and BMI.
Parvin Babaei, Arsalsn Damirchi, Ameneh Pourrahim Ghouroughchi ,
Volume 16, Issue 2 (summer 2016)
Background & objectives: Estrogen reduction after the menopause is associated with visceral adipose tissue accumulation and insulin resistance. Serum omentin-1 level is also decreased by abdominal obesity and insulin resistance. This study investigated the effect of estrogen on visceral fat, omentin-1 and insulin resistance in ovariectomized (OVX) rats.
Methods: Thirty 13-week-old female Wistar rats weighing180±5 gr were randomly matched on their body weight and divided into OVX (n=20) and sham-operated (SHAM; n=10) groups. OVX rats were subdivided into estrogen replacement therapy (Ovx+Est; n=10), and control (Ovx+sesame Oil; n=10) groups. The estrogen replacement therapy received 17b-estradiol (30µg/kg bw; in 0.2 ml sesame oil) three days a week, for eight weeks. Ovx+Oil received the same sesame oil subcutaneously as vehicle. All intra-abdominal fat depots were dissected out and weighed immediately. Omentin-1 concentration was measured by rat omentin ELISA kit and HOMA-IR was used to estimate the insulin resistance. Obtained data were analyzed by ANOVA and post hoc Tukey test.
Results: Visceral fat was decreased by 12.84% in Ovx+Est compared to Ovx+Oil group; but it wasn ́t significant. Whereas, body weight was significantly decreased by 7.87 % in Ovx+Est compared to Ovx+Oil; and it was significantly increased by 12.5% in Ovx+Oil compared to SHAM group. Omentin-1 level was significantly increased by 41% in Ovx+Est compared to Ovx+Oil group; whereas it was significantly decreased by 13.9% in Ovx+Oil compared to SHAM group. The levels of glucose, insulin and HOMA-IR were significantly decreased to 51.16%, 24.23% and 61.52%, respectively, in Ovx+Est group compared to the rats in Ovx+Oil group (p=0.0001).
Conclusion: 8-week estrogen reduces body weight and improves insulin resistance probably via increase in omentin-1.
Esmaeil Babaei, Vahid Montazeri ,
Volume 16, Issue 3 (autumn 2016)
Background & objectives: According to the new theory of cancer stem cells, interruption in the self-renewal pathway of tissue stem cells can cause cancerous tumors. Current work has evaluated the role of self-renewal Oct-4 gene in thyroid tumors.
Methods: In this case-control study, the expression of Oct-4 gene has comparatively assessed between cancerous specimens, marginal tissues of tumors and non-tumoral nodules of thyroid using RT-PCR technique.
Results: Statistical analysis of data by one-way ANOVA showed that Oct-4 gene is significantly expressed in thyroid papillary carcinomas in comparison with tumor margin and non-tumoral nodules (p<0.05).
Conclusion: In conclusion, the dominant expression of Oct-4 gene in thyroid tumoral cells not only demonstrates the cancer stem cell theory but also shows its role in thyroid cancer appearance that can be used in differentiating thyroid papillary carcinomas from non-tumoral nodules as well as demarcation of tumors.
Navideh Haghnavaz, Faezeh Asghari, Zeynab Sattari, Monire Babaei, Tohied Kazemi,
Volume 18, Issue 4 (winter 2019)
Background & objectives: Breast cancer is one of the most important cancers in women worldwide. Taxol as a chemotherapeutic agent, is used for treatment of breast cancer.The aim of this study was to investigate alterations in the expression of mir-1246 and mir-224 in four breast cancer cell lines after Taxol treatment with the goal of introducing them as a biochemical marker for determining response or resistance of breast cancer to the Taxol therapy.
Methods: In this in vitro study, four breast cancer cell lines including MCF-7, MDA-MB-231, SKBR-3 and BT-474 were cultured in RPMI1640 medium supplemented with 10% FBS and antibiotics. Then, MTT assay was performed to determine IC50 concentration of Taxol. Cells were treated for 24 hours and then RNA extraction and cDNA synthesis were performed. Alterations in the expression level of mir-1246 and mir-224 were quantitated using qRT- PCR.
Results: After treatment with Taxol, the expression level of mir-1246 was significantly up-regulated in two HER2-overexpressing cell lines, BT-474 (113 fold) and SKBR-3 (1.4 fold), and down-regulated in two HER2-negative cell lines, MCF-7 (45.5 fold) and MDA-MB-231 (7.7 fold). Expression of mir-224 was detected only in two cell lines including SKBR-3 and MDA-MB-231, and was down-regulated after treatment with Taxol (2.1 and 17.2 fold, respectively).
Conclusions: According to the different pattern of alteration in the expression level of mir-1246 in HER2-overexpressing breast cancer cell lines compared to HER2-negative cell lines after treatment with Taxol, this miRNA could be a useful biomarker for responsiveness to Taxol in different types of HER2-positive and -negative breast cancers.