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Showing 10 results for Asadi

Sarie Golmohamadloo , Farzane Broomand, Mitra Asadi Afshar ,
Volume 5, Issue 4 (Winter 2005)

 Background & Objectives: Unintended pregnancy is a worldwide problem. Despite abundant efforts by lranian family planning authorities during the last decade, unintended pregnancy and its consequences such as infected abortions is still a common problem. The aim of this descriptive study was to examine the causes of unintended pregnancy in Kosar Hospital, Urmia.

  M e thods : In this descriptive-analytical study the data were collected from 330 unintendedly pregnant women (out of 1830 pegnant women) visiting gynecology unit at Koshar Hospital in Urmia in 1999. These subjects were interviewed to fill out a questionnaire. Statistical analyses were performed with SPSS using t-test and Chi-square.

 Results: 83.6% of the cases were illiterate and 96.36% were housewives. 59.69% of the cases were above 30 79.09% had 3 or more children. The subjects used the following prophylaxy.

 Methods: thads. Pills (40%), withdrawal (25.5%), IUD (10%), injection (6.4%), minipills (4.5%), condom (3.6%) breast feeding (2.7%), rhythmic (0.9%) and tubectomy (0.6%). The remaining 5.8% had not used any prevention methods. We found a significant correlation between aging and number of unwanted pregnancies (P<0.0001 r = 0.44) and a negative meaningful correlation between literacy and rate of pregnancy (P<0.0001 r = 0.39). Reasons for failure were irregular use of pills, minipills or condom (90% each), unfamiliarity with prevention affter forgetting to take the pill (0.77%), IUD extraction, interrupted use of DMPA method and incorrect use of breast feeding method.

 Conclusion: This study reveals that desptie available prevention methods, due to lack of knowledge irregular use and misconceptions about complications of prevention methods, the subjects used unreliable methods which are more likely to lead to failure. Therefore, new measures should be taken in family planning centers to increase awareness among women concerning risk of unitended pregnancy.

Masoumeh Hajishafiha, Shaker Salari Lac , Minoo Khairi Tabar , Siyamak Naji, Mahzad Sadaghiani , Nahideh Asadi ,
Volume 11, Issue 1 (spring 2011)

  Background & objectives : Today there is a significant progress in the treatment of female infertility but there is no main improvement for the rate of implantation and live birth. This is because of non-implantation and early abortion that lead to decrease the rate of live birth. Genital infections such as bacterial vaginosis are common cause of this problem.

  Distinction and treatment of bacterial vaginosis is easy and non-expensive. Treatment of bacterial vaginosis could results in improving the rate of implantation and then live birth.

  Methods: We considered 209 infertile women treated with ICSI (intra cytoplasmic sperm injection). This study was performed in infertility clinic of KOSAR hospital affiliated to Urmia University of Medical Sciences, Iran.

  Before transferring of embryo, a sample was taken from posterior culdesac secretions by sterile cotton swap and fixed it on lamella. Then bacterial vaginitis was graded by a pathologist. The relationship of bacterial vaginosis with implantation and early abortion was studied. Data were entered into SPSS software and analyzed by t-test and Chi-Square test. p<0.05 is considered statistically significant.

  Results: Bacterial vaginosis was significantly more frequent in patients with tubal and ovulatory disorder (p=0.013). In women undergoing ICSI, bacterial vaginosis was not associated with decreased conception rate (p=0.892) and with increased rate of early pregnancy loss (p=0.44).

  Conclution: Bacterial vaginosis is prevalent in women with infertility. It is also the most important cause of infertility in patients with tubal and ovulatory disorder. Bacterial vaginosis does not affect fertilization rate.

Mohsen Mardani Kivi , Kamran Asadi , Keyvan Hashemi Motlagh,
Volume 11, Issue 4 (winter 2011)

  Background & Objectives: Anatomical reconstruction of articular surface and restoration of walking ability without pain are the main goals of displaced intra-articular calcaneal fracture management, but treatment results are not always satisfied. This paper focused on comparison between open reduction and internal fixation using: A) auto graft B) bone cement, in patients with displaced intra-articular calcaneal fracture.

  Methods : This prospective comparative study of 44 patients with displaced intra-articular calcaneal fractures. Patients had been divided into 2 groups and then, they were operated by the standard protocol, including lateral approach, open reduction and internal fixation with reconstruction plate. Posterior facet was supported by autogenous bone graft in the first group (BG) and it was strengthened by bone cement in the second group (BC). Patients were followed up from the point of view of following surgical complications: 1- superficial infection, 2- wound dehiscence, 3- incisional site skin necrosis, 4- Sural nerve paresthesia, 5- osteomyelitis. Functional outcome were evaluated using calcaneal fracture scoring system and ankle-hind foot scaling system of AOFAS. The gathered data was analyzed in SPSS 16 software.

  Results : Of 44 included patients, 36 were male (81.8%) and eight were female (18.2%). The mean of age was 44.25± 11.34 (range: 16-69 yrs), and the mean of follow-up duration was 13.27±2.71 months (range: 9-18 months). The mean of operation time in second group (BC) (41.82min) was significantly lower than first group (BG), (p<0.001). Five patients (23%) from first group (BG) and only one patient (5%) from the second group (BC) showed surgical complications (p=0.079). There was no significant difference between the average score evaluated by calcaneal fracture scoring system and the average scale indicated by ankle-hind foot scaling system.

  Conclusion : Instead of autogenous bone graft, the use of bone cement decreases the duration of operation time and it seems to lead in less complications.

Kazem Moazedi, Abdollah Asadi,
Volume 12, Issue 1 (spring 2012)

  Background & Objectives: R eligion and its guidelines have important role on the mental health of people. Many studies show that moral and religious beliefs and behaviors lead to mental relaxation and pleasant living. Religious person shall try to be more helpful and successful in all fields of cultural, social, political and economic life. The aim of this article is to elucidate the role of mental health in the Holy Quran.

  Methods: This study was performed by the library field based on the results of the existing related researches and reliable sources.

    Results : If the human psyche is not understood, he could not achieve his perfection and maturity. It is because of lack of knowledge about the mental and spirit damages. How we can understand self and psyche and which information source is the best to refer?

  From the viewpoint of Quran, the first way to deal with psychological stress is back to human nature which is the base of mental relaxation. Avoid of human nature could lead to moral disorders. Therefore in Islam, regarding human nature is considered to improving mental health.  

  Conclusion: According to our discussion, one of the best and most reliable ways for maintaining and improving mental health includes spiritual beliefs and using concept of God in Holy Quran.

Manoochehr Barak , Saeid Sadeghieh Ahari , Firouz Amani , Gholamreza Asadi, Gity Rahimi , Elham Khadem,
Volume 12, Issue 5 (suppl 2012)

  Background & Objective: Currently, migration of rural population to cities and developing slums around them are main problems in population settlement that lead to imbalance in health standards such as difference in age groups death. The aim of this study was to examine factors associated with infant mortality in slums of the Ardabil city.

  Methods: This was a case- control study. All infants’ deaths from 2008 to 2010, which occurred in slums as a case, were included. For each case, tow controls, were chosen. Controls the ones who survived and were living in non marginalized area and years of birth and sex were matched in two groups. Information collected from health centers through questionnaires, interviews with parents and child death files.

  Results: The majority of mortalities (74.6%) were in neonatal period and 25.4% was in post- neonatal period. The most important causes of deaths in neonatal were prematurity (57%), and in post neonatal period were congenital abnormality (35.4%). Analysis of effective factors showed that birth weight, parents age and education, family income and occupation and smoking of father were highly associated with mortalities.

  Conclusion: Infant mortality of the family that their father is a smoker and they have low income, and low parental education level is significantly higher and should be taken into serious consideration to reduce the mortality.

Asadollah Asadi , Arash Abdolmaleki, Farhood Najafi,
Volume 13, Issue 1 (spring 2013)

  Background & Objectives: Polymers as drug carriers are recent advances in drug delivery and led to the new advent field that called polymer treatment. In the present study, the toxic and teratogenic effects of BDP18 were evaluated against chicken embryos as a model.

  Methods: The BDP18 tri-block copolymer (PLA-PEG2000-PLA) was synthesized. The compound solution was injected in triplicate examination, in the air sac of the eggs, at third day of incubation, and survived fraction of the embryos and Morphological and skeletal changes were recorded .

  Results: The survived fraction of the embryos depends on the compound concentration. In concentration of 20 mg/ml , 33.3% of the embryos were survived and the LD50 was 10.87 mg/egg . Morphological study of the treated embryos showed no abnormalities in embryos , and skeletal staining showed the deletion of caudal vertebrate in high concentration.

  Conclusion: The BDP18 copolymer had low toxic and teratogenic effects against the embryos, but it caused the deletion of caudal vertebrate at concentrations above the threshold (10 mg/ml). This polymer can be used as an effective drug -release system in low concentrations .

Mohammad Hosein Razi Jalali, Somayeh Bahrami , Hosein Najafzadeh , Zeynab Asadi,
Volume 14, Issue 3 (Autumn 2014)

  Background & objectives: The leishmaniases are considered among the major infectious diseases affecting public health in several regions. There are many chemical agents which are effective in treatment of visceral leishmaniasis. But, overall treatment of visceral leishmaniasis is often difficult. Thus, identification of new chemotherapeutic agents is important for treatment of disease. Since targeting of the ergosterol synthesis pathway of Leishmania may be useful therapeutically, the aim of this study was to investigate the effect of alone or in combination of amiodarone and ketoconazole on Leishmania infantum.

  Methods : To obtain logarithmic promastigotes of L. infantum, the parasites were cultured in BHI medium with FCS 10% together with antibiotics of penicillin and streptomycin and incubated at 24° C. Amastigote forms were obtained in BHI medium supplemented with 20% FCS at pH of 5.5 which incubated in 37° C. L.infantum susceptibility to amiodarone and ketoconazole was evaluated by proliferation of parasites in the absence or presence of these drugs with MTT assay. For evaluation of antiproliferative synergism against promastigotes and axenic amastigotes, fractional inhibitory concentrations (FIC) were calculated. An isobologram curve was constructed too.

  Results: Amiodarone produced a marked reduction in the viability of L.infantum promastigotes and axenic amastigotes. On the other hand ketoconazole induced a dose dependent effect on the parasites proliferation for promastigotes and axenic amastigotes. When the drugs were used in combination, the results indicated clear synergistic as shown by a concave isobologram and FIC value.

  Conclusion: The present study represents the evidence that the combination of amiodarone plus ketoconazole acts synergistically in controlling L. infantume in vitro. It is possible that amiodarone could be used in combination with ketoconazole to combat infection at low doses, thus reducing its side effects such as cardiotoxicity, thyroid dysfunction and pulmonary fibrosis.

A Shamsazar, A Asadi, F Shamsazar,
Volume 15, Issue 3 (autumn 2015)

Background & Objectives: Maintain of fixed amount of glucose in blood has always been valuable. Especially in diabetic patients it is important to determine accurate amount of it. In this study we are trying to find a method to determination of the amount of serum glucose.

Methods: First a biosensor was prepared using carbon paste electrode modified with Copper Oxide nanoparticles for determination of serum glucose. The synthesized Copper Oxide nanoparticles were studied by using a variety of chemical spectrum UV-Vis, XRD, SEM and TEM. XRD confirmed that our synthesized are Copper Oxide nanoparticles. By measuring of the oxidation currents in the several levels of glucose, the accuracy and efficiency of biosensor was studied.

Results: Based on a increase of the electrocatalytic response of the oxidized form of GOD to dissolved oxygen, the proposed biosensor exhibits a linear response to glucose concentrations ranging from 0 to 15 mM with a detection limit (defined as the concentration that could be detected at the signal-to-noise ratio of 3) of 9 �M at an applied potential of 0.44 V which has better biosensing properties than those from other biosensors. This biosensor retained 89% of its initial response after 30 days storage at pH=7.

Conclusion: Carbon paste electrode and Copper Oxide nanoparticles offer excellent catalytic activity toward hydrogen peroxide generation in enzymatic reaction between glucose oxidase and glucose, which would enable sensitive determination of glucose. This biosensor exhibited good stability, reproducibility and low interferences. It has been used to diagnose diabetes very fast and sensitively and to determine the glucose concentrations in serum samples with satisfactory results.

Abdollah Asadi , Hamed Rezakhani Moghaddam , Aghil Habibi, Kazem Moazedi, Yoosef Hamidzadeh, Mohaamad Taghi Savadpour,
Volume 15, Issue 4 (winter 2016)

Background & objectives: Social capital is defined as norms and networks which provide conditions for participation in social activities in order to profit mutually. This study was designed to evaluate the social capital status of students of Ardabil University of Medical Sciences and its relationship with religious attitudes.

Methods: This was a cross-sectional study of 500 students from Ardabil University of Medical Sciences during second half of the academic year 2014. Data were collected using demographic, social capital and religious attitudes questionnaires and analyzed by SPSS 22 using T-Test, Pearson correlation and ONOVA tests.

Results: Total means score for social capital was 80.0±16. There was significant correlation between all dimensions of social capital (except for dimension of family and friends connections) and religious attitudes status (p<0.05).

Conclusion: Due to the influence of social capital and its relationship with the religious attitude, it can be a guide for reduction of concerns about the educated classes and increasing their social capital

Maryam Salem , Tooba Mirzapour, Aboulfazl Bayrami, Mohsen Sagha, Asadollah Asadi,
Volume 17, Issue 1 (spring 2017)

Background & objectives: According to importance of bone marrow mesenchymal stem cells in production of different cell lines, transplantation of these cells are used for treatment of many different diseases during cell therapy. Viability and proliferation of these cells after transplantation are very important. Since infertility is as public health problem in men and women, the scientists attempt to produce germ cells from differentiation of stem cells. It is supposed to use these cells for treatment of different illnesses especially for men with lack of germ cells in testes in future. However, in using stem cells for cell therapy the culture medium should be designed to increase the number of cells and efficiency of transplantation and to guarantee the health of the cells in terms of DNA damage. This study designed a suitable culture medium in order to increase the number of colonies and decrease the cell injuries.

Methods: In this study mesenchymal stem cells isolated from bone marrow of mice and exposed to retinoic acid (RA) with concentration of 10-6 M and Sertoli cells condition medium. Since mesenchymal stem cells (MSCs) produce fibroblastic colonies so the number of colonies was counted every 3 days after culture (days of 2, 5, 8, 11, and 15) under inverted microscope. The staining of ethidium bromide-acridine orange was also done for determination of apoptotic nucleus in days of 10 and 15 after culture.

Results: The results showed that the effects of retinoic acid on grow and viability of MSCs is related to the time. It seems that RA increased the proliferation of the cells and the number of colonies increased in low time but the apoptotic cells elevated with increasing the time of culture. Condition medium of Sertoli cells also increased the proliferation of bone marrow stem cells.

Conclusion: According to proliferative properties of condition medium, it seems that using condition medium together with RA is better than RA alone for differentiation of MSCs to germ cells.

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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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