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Showing 5 results for Argani

Homayoun Sadegi BazArgani , Shahnam Arshi, Ali Akbar Mortazazadeh, Jafar Bashiri , Naiere Aminisani, Saied Hashem Sezavar , Hasan Adalatkhah , Shahram Seifnejad, Ali Ruhi, Hale Shahlazadeh ,
Volume 5, Issue 2 (Summer 2005)

 Background & Objectives : Providing health services for all population subgroups of a community is a major hallmark for health administration. Little is known about health status of Ashayer population in Iran. This study aims at evaluating health status and quality of health service delivery to them.

 Methods: In a cross-sectional research 320 households (1800 persons), entered the study. Moreover, blood samples from 458 dogs were taken and studied with both Direct Aglutination Test (DAT) and a newly presented dipstick test . All children under 12 were also studied with DAT. In computing the sample size the generalizability for 63 variables with a minimum and maximum probability level of 90% and 97% respectively were taken into account and since the cluster sampling was employed, the Design Effect would be at least 1.56 and for different variables in the first sample it would be at most 4.

 Results: Only 30 households(9.7%) used piped water supply inside their houses while most of the other families (41%) obtained their water from mobile water tanks. Residual water chlorine was measured to be zero in 88.7% of the samples taken from drinking water of Ashayer. 89 (27.8%) households had lavatories and 22 (7%) households had bathrooms inside their houses. 90.4% of those using raw vegetables washed them only with plain water. Monthly incidence rate for accidents was 230 per 10000. 18.1% of women in reproductive age had a history of abortion. Unwanted pregnancy rate was 38.9%. 47.1% of women with a labor history in past three years had never been visited by any person legally allowed to do so. Women in reproductive age had a poor knowledge about contraceptive methods. The minimum delay for vaccination was 16.9 (SD= 19.26) days regarding the third dose of OPV and the highest delay in vaccination was 46.44 (SD=60.7) days belonging to the third dose of HBV. From all 503 persons above 12 years old, 77 cases had hypertension. Periodontal easy bleeding was observed in 13.7 % and pyorrhea in 19.3%. 10.2 % had aching neck, 18.7% had backache and arthralgia was shown in 13.5%. The unmet need for physician's visit was 64.8%. The frequency of positive cases of leshmaniasis was 3.4% and 3.06% for boys and girls respectively. 28 male and 6 female dogs were positive in DAT test making an overall positive rate of 7.4%. Sensitivity of dipstick test was higher than 80 percent only when golden standard was considered to be DAT ≥ 1 /640.

  Conclusion: Many of the health indices of Ashayer except for vaccination were suitable. This requires further attemps on the part of govermental and health outhorities. Kale-azar disease can spread to the north of the province as well as the neighboring provinces due to the migration of these tribes. It is predicted that Bilesavar and Parsabad cities will be added to the andemic regions of this disease in coming years. Using dipstick test recently offered by WHO is recommended to be used to screen the infected dogs.

Mohammad Mazani , Hasan Argani , Nadereh Rashtchizadeh , Mohammad Rohbaninoubar , Amir Ghorbanihagjo , Reza Mahdavi , Reza Razzaghi , Babak Rahimi Ardabily , Seyedjamal Ghaemmaghami ,
Volume 6, Issue 3 (Autumn 2006)

  Background and Objectives: A great amount of evidence shows that Oxidative stress is high among hemodialysis patients. The purpose of present investigation is examination of the effect of zinc supplementation on improvement of oxidative stress in chronic hemodialysis patients.

  Methods: In this double blind clinical trial 65 chronic hemodialysis patients were studied in two groups Group one (35 patients) received placebo and group two (30 patients) received 100 mg elemental zinc (as zinc sulfate) daily for 2 months. The placebo and supplement discontinued in next 2 months. Then, the study continued for two other months in the cross-over from. The levels of serum zinc, total glutathione, malondialdehyde (MDA), total serum antioxidant capacity and the activity of whole blood superoxide dismutase (SOD) were determined on 0th, 60th,120th,180th days, in fasting, predialysis samples. Food record was recorded for one day prior to dialysis in above-mentioned days and their dietary zinc was assessed.

  Results: Basal serum zinc levels in both groups were below 80 μ g/dl. The zinc upplementation led to significant increase in the levels of serum zinc in both groups .The levels of serum total antioxidant capacity, total glutathione and activity of whole blood SOD increased significantly during zinc supplementation period. The concentrations of serum MDA decreased significantly in zinc supplementation period in both groups. During the placebo period the levels of MDA in first group increased significantly, whereas the concentration of glutathione in second group decreased significantly. The body mass index (BMI) values did not change significantly during the study.

  Conclusion: It can be concluded that in patients undergoing hemodialysis the oxidative stress enhanced during nonsupplementation period (zinc sulfate). Low serum zinc levels are improved by zinc administration and zinc supplementation improves oxidative stress.

Masoud Noroozianavval , Peghah Veisi, Mohammad Aghaeishahsavari , Hasan Argani, Nadere Rashtchizadeh, Amir Ghorbanihaghjo,
Volume 7, Issue 3 (Autumn 2007)

  Background & Objectives : Panel-reactive antibody (PRA) is a routine test to evaluate for sensitized human leukocyte antigens (HLA) before kidney transplantation. The present study evaluates the correlation of renin-angiotensin system (RAS) polymorphisms with the level of PRA in renal transplant candidates.

  Methods: This study included 108 renal transplant candidates. The current patients sera were screened by standard complement-dependent microlymphocytotoxicity technique. RAS polymorphisms were determined by polymerase chain reaction. PRA<10, 10-29, 30-49, and ≥50 considered as negative, mild, moderate, and highly positive PRA, respectively.

  Results: Twelve (11.1%) patients had positive PRA, among them 10 (83.3%) had mild and 2 (16.7%) of them had moderate PRA levels we had no highly positive PRA. Ninety-six of cases (88.9%) were negative for PRA. There was no significant correlation between discrete RAS polymorphisms (alone or together) and the degree of panel antibody reactivity (P>0.05).

 Conclusion: We suggest that none of the RAS polymorphisms could predict the positivity degree of PRA level.

Mohammad Aghaeishahsavari , Masoud Noroozianavval, Peghah Veisi , Hasan Argani , Nadereh Rashtchizadeh , Amir Ghorbanihaghjo, Sima Abedi-Azar, Amirmansoor Vatankah,
Volume 8, Issue 2 (Summer 2008)

 Background & Objective: As renin-angiotensin system (RAS) activity could affect the severity of oxidative stress and inflammatory markers the effect of enalapril and losartan on these markers in renal transplant recipients (RTRs) with RAS polymorphisms was assessed.

 Methods: After determination of RAS genotypes including angiotensin converting enzyme (ACE I/D), Angiotensinogen (AGT M235T) and angiotensin II type 1 receptor (ATR1 A1166C) by PCR, seventy-six RTRs recruited to four groups randomly: first group (17 patients) and second group (24 patients) were treated with E (E+: 10mg/daily) and L (L+: 50 mg/daily) alone, respectively. The third group (17 patients as positive control) received E+L (E+L+: 10mg/daily + 50 mg/daily) and the 4th group (18 patients as negative control) received no medication (E-L-). Hs-CRP and total anti-oxidant (TA) as inflammatory and anti-oxidative markers were measured after 2 months. After 2 weeks as washout period, E group changed to L and vice versa as a cross-over design. They were followed for another 8 weeks and hs-CRP and TA were retested.

 Results: Following up the patients (after 2, 4 months of treatment) in treated groups revealed that hs-CRP and TA levels were significantly decreased and increased (consequently) in E+L+, L+, E+ groups (P<0.05). On analyzing the relationship between RAS polymorphisms with baseline hs-CRP and TA levels, CC genotype of ATR1 had lower hs-CRP levels (P=0.04). But none of the RAS polymorphisms could predict the anti-oxidative and anti-inflammatory response rate to the drugs (P>0.05).

 Conclusion: E and/or L reduce hs-CRP and increase TA regardless of the RAS genotypes.

Mohammad Mazani , Hormoz Iremlou, Hasan Argani ,
Volume 10, Issue 2 (summer 2010)

  Background and Objectives: Neuropathy is a common complication in hemodialysis patients. The purpose of this investigation is examination of the effect of zinc supplementation on nerve conduction velocity in chronic hemodialysis patients.

  Methods: In this clinical trial 65 chronic hemodialysis patients were studied in two groups: Group one (35 patients) received 100 mg placebo (corn starch) and group two (30 patients) received 100 mg elemental zinc (as zinc sulfate) daily for 2 months. The placebo and supplement discontinued in the next 2 months. Then, the study continued for two other months in the cross-over form group one received 100 mg zinc and group two received 100 mg placebo daily for 2 months . The function of central and peripheral nerves were evaluated at the 0th, 60th, 120th, 180th days by nerve conduction velocity of electrodiagnostic test .

  Results: The function of nerves didn’t change significantly or some parameters markedly decreased in placebo period in both groups. Significant increase was found in the function of nerves during zinc supplementation period in both groups.

  Conclusion: These data indicate that zinc supplementation improve neuron function in patients undergoing hemodialysis

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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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