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Showing 2 results for Abtin

Farzad Izadi , Seyedbehzad Pousti , Fathollah Mousavi , Mohammad Mohseni , Abtin Doroudinia ,
Volume 4, Issue 3 (Autumn 2004)

  Background & Objectives: Recurrent respiratory papillomatosis (RRP) is the most common benign laryngeal tumor and the second common cause for hoarseness in children. Despite its omplete benign histology, it has a great tendency to spread through the respiratory track and frequent recurrences may occur following surgery, possibly due to the virus survival in apparently healthy adjacent tissues. According to the most recent evident experiences, the treatment of choice for RRP disease is repetitive resections with CO2 laser. The present study evaluates the efficacy of adjuvant medical therapies for eradication of this disease in affected children.

  Methods : This was an experimental study with sequential control (self-control). The subjects were children who referred to ENT-H&N surgery dept. of Hazrat-e- Rasoul hospital in Tehran between Mar 1998 and Mar 2001 with chief complaint of hoarseness and respiratory obstruction. Among these children patients with confirmed diagnosis of RRP were selected as study samples and the effect of acyclovir and alpha-interferon combination in reducing the severity and recurrence of RRP was evaluated.

  Results: Totally 18 patients entered this study (10 (55.5%) females and 8 (44.5%) males). The mean age of the patients was 6.5 and 94% of them were the first child of young mothers (under 25 years of age). The signs of respiratory obstruction in most of the cases with a mild to moderate severity was the main cause of referral in 45% of the subjects. Laryngeal lesions were mostly superficial and limited to glottis region. Severity and spread of RRP disease was greater in children under 3, which led to tracheotomy in 3 of them. The combined administration of alpha-interferon and acyclovir, made a significant reduction in disease severity and spread in 55.6% of the patients.

  Conclusion : The findings of this study indicated that combination of acyclovir and alpha-interferon can be effective in reducing RRP recurrences and severity. Nevertheless, because of small sample size(due to rarity of RRP), Further multi-institutional studies are required to obtain a greater sample size and more valid results.

Shima Abtin, Lotfollah Khajehpour, Mahnaz Kesmati, Hosein Najafzadeh,
Volume 15, Issue 4 (winter 2016)

Background & objectives: Salvia officinalis is one of the memory-enhancing herbs that were used in the past. On the other hand, iron oxide nanoparticles which are widely used in medicine and industry may impair the brain process related to memory. In this investigation, the effect of hydro-alcoholic extract of Salvia officinalis on iron oxide nanoparticle induced memory impairment and the role of beta-adrenergic receptors in this effect were studied.

Methods: To assess the inhibitory avoidance memory, animals were trained in the step-down task and drugs (saline, hydro-alcoholic extract of sage leaves, nanoparticles of iron oxide and propranolol) were injected immediately after training by intraperitoneal (ip) injections. Long-term memory was tested 24 hours later and step-down latencies were recorded.

Results: Administration of iron oxide nanoparticles (5 mg/kg, ip) impaired memory retrieval. Salvia officinalis extract (40 mg/kg, ip) also prevented iron oxide nanoparticle induced long-term memory impairment. On the other hand, administration of propranolol (5, 10 mg/kg, ip) before Salvia officinalis extract (40 mg/kg, ip) and iron oxide nanoparticles (5 mg/kg, ip) attenuated the effect of Salvia officinalis extract.

Conclusion: It seems that extract of Salvia officinalis leaves decreases iron oxide nanoparticle induced memory impairment. Beta-adrenergic mechanisms are possibly involved in these effects of Salvia officinalis extract.

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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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