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Showing 3 results for Subject: بیوشیمی

Rasoul Sharifi , Akbar Nazari ,
Volume 18, Issue 3 (10-2018)

Background & objectives: Metalloproteinases (MMPs) are one of the most important agents in cartilage damage in rheumatoid arthritis. Increase of these enzymes can change sensitivity to insulin. Therefore, in this study, the MMPs level, insulin sensitivity index and effective factor related to rheumatoid arthritis were evaluated in obese female with rheumatoid arthritis.
Methods: In the present study, 50 obese women with rheumatoid arthritis who were referred to the Sheikh Al-Reis clinic and Sina hospital in Tabriz and 50 healthy obese individuals were considered as case group and control group respectively. After determining the body weight, the levels of MMP-1, MMP-3, MMP-13, insulin, leptin, visfatin, resistin and glucose were measured using ELISA and Pars -Azmoon kits. One-way ANOVA method was used for statistical analysis of data. Pearson correlation test was used to evaluate the correlation between variables (p<0.05).
Results: in the present study, the mean level of MMP-1 (p=0.008), MMP-3 (p=0.015) and MMP-13 (p=0.001) in the case group was significantly higher than the control group. Also, Insulin- sensitivity index analysis didn’t show significant difference between the case group and the control group (p=0.21). In the case group, the level of leptin (p=0.000), resistin (p=0.000) and visfatin (p=0.024) was significantly increased compared to control group while insulin (p=0.231) and glucose (p=0.430) levels didn’t show significant increase.
Correlation results showed that there was a negative correlation between insulin and MMPs and a positive correlation with other parameters affecting insulin sensitivity.
Conclusion: our results showed, the matrix metalloproteinase level and the level of some factors affecting insulin sensitivity have increased in rheumatoid arthritis disease. Also, there was a significant positive correlation between the matrix metalloproteinase and some parameters affecting insulin sensitivity, including resistin and visfatin.
Sepideh Ahmadi Sagerlou , Reza Alipanah-Moghadam, Ramin Salimnejad,
Volume 18, Issue 4 (3-2019)

Background & objectives: One of the most important diabetes complications is chronic renal failure. This disorder is one of the most important progressive renal problems that is closely associated with high mortality rate in diabetic patients. The purpose of this study was to evaluate the effect of conjugated blackcurrant extract and  zinc oxide nanoparticles on histopathologic damages of kidney tissue in diabetic rats.
Methods: A total of thirty adult Wistar rats were used and they were randomly divided into the following six groups (n=5): control group; diabetic group (170 mg/kg alloxan); diabetic group treated with insulin (170 mg/kg alloxan & 10 U/kg insulin); diabetic group treated with ZnO nanoparticle (170 mg/kg alloxan & 8 mg/kg ZnO nanoparticle); diabetic group treated with extract (170 mg/kg alloxan & 150 mg/kg blackcurrant extract) and diabetic group treated with extract conjugated with ZnO nanoparticles (170 mg/kg alloxan & 8 mg/kg blackcurrant extract conjugated with ZnO nanoparticle). Diabetes mellitus was induced by intraperitoneal injection of alloxan monohydrate. Conjugated blackcurrant extract and ZnO nanoparticles were produced using green synthesis method. The tissues were stained with hematoxylin and eosin stain. Image J software was used for evaluation of histopathological changes.
Results: The comparison between groups treated with blackcurrant extract, ZnO nanoparticles and blackcurrant extract conjugated with ZnO nanoparticle showed that these compounds somewhat protect kidney tissue from diabetes damage . The highest protective effect was observed in diabetic group treated with ZnO nanoparticles conjugated with blackcurrant extract.
Conclusion: Our study, for the first time, showed that the conjugation of blackcurrant extract to ZnO nanoparticles can be effective in preventing renal- tissue damage in diabetic patient.

Masoud Ojarudi, Mohammad Mazani, Reza Hajihosseini, Alireza Moradi, Lotfollah Rezagholizadeh,
Volume 18, Issue 4 (3-2019)

Background & objectives: Considering the importance of liver toxicity due to drugs and toxins as a major cause of liver damage, this study was conducted to evaluate the effects of the combination of cinnamon and ginger extracts on serum biochemical parameters in carbon tetrachloride (CCl4)- intoxicated rats.
 Methods: In this experimental study, forty-two male Wistar rats were divided into 7 groups (n=6). Three control groups including normal control, combined extract control and damaged control were designated that received distilled water, a mixture of cinnamon and ginger extracts and distilled water respectively for 14 days.
 Other 4 groups were pre-treatment  groups which were treated with cinnamon (50 mg/kg/d), ginger (250 mg/kg/d), cinnamon + ginger (25+125 mg/kg/d) and silymarin (100 mg/kg/d) respectively for 14 days before being damaged by intraperitoneal injection of CCl4 (1 ml/kg, 1:1 in olive oil). Fifty - two hours after CCl4 injection, blood sampling was performed and biochemical parameters were measured in serum of rats.
Results: The results of this study showed that the injection of CCl4 significantly increased the ALT and AST enzymes activity ,cholesterol, triglyceride, and LDL levels and decreased the blood albumin and HDL levels in damaged rats compared to the normal control group (p<0.001). However, pre-treatment with the cinnamon and ginger extracts, especially combination of extracts significantly improved these values ​​compared to the CCl4 damage group (p<0.001).
Conclusion: The results suggest that simultaneous use of cinnamon and ginger extracts has more significant protective effects against CCl4-induced hepatotoxicity.

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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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