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:: Volume 12, Issue 3 (autumn 2012) ::
J Ardabil Univ Med Sci 2012, 12(3): 265-275 Back to browse issues page
Dose-Dependent Effect of GABAA System on Antinociception Actions of Cuneiformis Nucleus in Brain Stem
Hamid Sheikhkanloui Milan
Abstract:   (5267 Views)

 Background & Objective: It's been considered that midbrain region namely rostral ventromedial medulla (RVM) is the coring point of modulation of pain. The periaqueductal gray (PAG) matter has been documented to act as antinociceptive along with RVM. However, there are evidences demonstrating that RVM get a few connections from the cuneiformsnucleus (CnF) which might indicate CnF does have the same mechanism as PAG. Thus in this study, we tried to explore the antinociception effects of CnF and GABAA circuits.

 Methods: Rats were anesthetized with Thiopental drug. Using the stereotaxic apparatus and Paxinos atlas, the point representing for CnF location over the scalp has been designated. One week after the surgery, rats were fully prepared for tests. Animals were put in three groups. First for control group, 0.5 µl of normal saline was injected into the CnF. Later, a few nanograms of bicucculline (as a GABAA antagonist) were administered into the CnF, dose dependently.

 Results: From the results, it has been shown that CnF has a role in antinociception effect since the injection of bicucculline increased tail flick latency (TFL) and even further increased TFL when administered dose dependently (with high doses).

 Conclusion: According to results of current study, CnF has a significant role in pain modulation and circuits of GABAergic system also plays a key role on its antinociception effect.

Keywords: Nucleus Cuneiforms; Morphine; Bicucculline; GABAA Receptors; Pain Modulation
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Type of Study: article | Subject: Special
Received: 2012/07/11 | Accepted: 2012/09/22 | Published: 2012/10/2
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Sheikhkanloui Milan H. Dose-Dependent Effect of GABAA System on Antinociception Actions of Cuneiformis Nucleus in Brain Stem. J Ardabil Univ Med Sci. 2012; 12 (3) :265-275
URL: http://jarums.arums.ac.ir/article-1-85-en.html

Volume 12, Issue 3 (autumn 2012) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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