:: Volume 17, Issue 3 (autumn 2017) ::
J Ardabil Univ Med Sci 2017, 17(3): 375-382 Back to browse issues page
Hypolipidemic Effects of Aloe-Vera Gel Extract on Adult Male Rats under High-Fat Diet
Nooshin Yazdani, Seyeh ebrahim Hosseini
Department of Biology, Faculty of Basic Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran
Abstract:   (3525 Views)
Background & objective: Aloe-vera is an herb   that has long been used in traditional medicine. Using high-fat diet and fatty liver disorder cause obesity and hyperlipidemia. So, this study aimed to investigate the effects of Aloe - vera gel extract on the body weight and lipid profile in adult male rats treated with high-fat diet.
Methods: In this experimental study, 40 adult male rats were included in the control group (no treatment), sham group (treated with high-fat diet 10 ml/kg) and three experimental groups receiving high-fat diet (10ml/kg) along with 150, 300 and 600 mg/kg Aloe- vera gel extracts. Prescriptions were conducted by gavage, for 60 days. At the end, after anesthetizing the rats and phlebotomizing their heart, the serum levels of cholesterol, triglycerides, LDL and HDL were measured.   The obtained results were analyzed by ANOVA and Duncan tests.
Results: The results showed that high-fat diet significantly increased the serum levels of cholesterol, triglycerides, LDL (p<0.001) and weight gain (p<0.01) but had no significant effect on the serum level of HDL. However, in the groups receiving Aloe -vera gel and   high-fat diet, there was a significant decrease in the weight and serum levels of cholesterol, triglyceride (p<0.05) and LDL (p<0.01).
Conclusion: High-fat diets increase the weight and serums levels of triglycerides, LDL and cholesterol.  Also, the Aloe- vera gel extract causes weight loss and improves lipid profiles in the rats treated with Aloe -vera gel extract.
Keywords: Aloe-Vera Gel, Weight Loss, Lipid Profiles, High-Fat Diets, Rat
Full-Text [PDF 333 kb]   (1287 Downloads)    
Type of Study: article | Subject: General
Received: 2017/04/19 | Accepted: 2017/09/21 | Published: 2017/10/2


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Volume 17, Issue 3 (autumn 2017) Back to browse issues page