:: Volume 17, Issue 1 (spring 2017) ::
J Ardabil Univ Med Sci 2017, 17(1): 104-112 Back to browse issues page
Effect of Oral Administration of Ethanolic Extracts of Propolis on Passive Avoidance Learning and Memory in Adult Male Mice
Nematollah Gheibi, Javad Shahbazi, Zahra Zarmohammadi, Mahmoud Alipoor Heydari, Eftekhar Kakaeie, Mohammad Sofiabadi
Abstract:   (3683 Views)

Background & objectives: Propolis is a natural product with powerful antioxidant and therapeutic effects. The aim of this study was to investigate the effect of propolis on passive avoidance memory in adult male mice.

Methods: In this study, 40 adult male mice were divided into 8 groups, including control, sham (solvent) and 3 treatment groups orally treated with 50, 100 and 200 mg/kg of propolis, respectively for two weeks before and one week after treatment. Then, passive avoidance learning and memory were recorded in timescales of 24 and 48 hours, 4 days and a week after shock by the shuttle box. Data were analyzed by ANOVA and Dunnett’s post hoc tests, and p<0.05 was considered significant.

Results: Administration of propolis (50 mg/kg) significantly increased the dark chamber entering time at intervals of 24 and 48 hours (p<0.001) and at concentrations of 100 and 200 mg/kg in all time periods after the shock (p<0.001).

Conclusion: Oral administrations of propolis can improve learning and memory dose-dependently in adult male mice.

Keywords: Propolis, Passive Avoidance Memory, Mice
Full-Text [PDF 139 kb]   (1060 Downloads)    
Type of Study: short communication | Subject: General
Received: 2016/11/21 | Accepted: 2017/03/10 | Published: 2017/03/30


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Volume 17, Issue 1 (spring 2017) Back to browse issues page