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J Ardabil Univ Med Sci 2012, 12 - suppl: 24-32 Back to browse issues page
Survey the Effect of Low Dose Aspirin on Serum Level of Uric Acid in Patients with Ischemic Heart Disease
Behzad Babapour , Shahram Habibzadeh, Alireza Mohammadzadeh, Nafiseh Mafi, Elham Atighi, Edalat Hoseinian, Bita Shahbazzadegan
Abstract:   (6157 Views)

  Background & Objectives: Low dose aspirin has been widely used in the prevention and treatment of cardiovascular disease. The bimodel action of aspirin on serum uric acid showed that aspirin at a high dosage promoted uricusuria while intermediate doses were (1-2gr/day) caused uric acid retention. The main goal of this study was to survey the effect of low dose aspirin on serum level of uric acid in patients with ischemic heart disease.

  Methods: The study design was cross-sectional and analytical type. In this study we selected 60 patients who used low dose aspirin among the patients of Imam Khomeini hospital's heart clinic (2008-9) and their information was registered in special questionnaires including serum level of uric acid and creatinine before and after prescription of aspirin. Data was then statistically analyzed using Paired t test and Willcoxon.

  Results: Of 60 patients 11 ( 18.3 % ) were under 50 years and 49 ( 81.7%) were above 50 years. The male to female ratio was 1.72 (38: 63.3% versus 22: 36.7%). 53.3 % of patients showed an increase in serum uric acid, but 46.7% did not. No significant differences in uric acid levels was found in patients under 50 years before and after administration of aspirin. Serum uric acid levels were increased after administration of 0.1unit of aspirin.

  Conclusion: Low -dose aspirin (80 mg/ day) caused a slight but significant increase in serum uric acid and creatinine levels in patients over 50 years of age.

Keywords: Aspirin; Uric Acid; Ischemic Heart Disease
Full-Text [PDF 175 kb]   (2169 Downloads)    
Type of Study: article | Subject: Special
Received: 2012/03/11 | Accepted: 2012/11/11 | Published: 2012/11/21
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Babapour B, Habibzadeh S, Mohammadzadeh A, Mafi N, Atighi E, Hoseinian E et al . Survey the Effect of Low Dose Aspirin on Serum Level of Uric Acid in Patients with Ischemic Heart Disease. J Ardabil Univ Med Sci. 2012; 12 (S1) :24-32
URL: http://jarums.arums.ac.ir/article-1-94-en.html


Volume 12 - suppl Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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