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:: Volume 15, Issue 2 (summer 2015) ::
J Ardabil Univ Med Sci 2015, 15(2): 128-136 Back to browse issues page
Effect of the Injection Speed of Streptokinase in Patients with Acute MI Admitted to the Cardiac Intensive Care Section of Imam Khomeiny Hospital in Ardabil 2011-2012
B Zamani, M Azari , A Hosseinian, A ShokrDargahy, A Mardi, Sh Azari
Abstract:   (5664 Views)

Background & objectives: Myocardial infarction (MI) isone of the most commonly heart diseases in all countries with the mortality rate of about 30%. Reperfusion of blocked coronary arteries plays an important role in reducing mortality and enhancing the quality of life of patients after acute MI. 

Methods: This clinical trial is to compare the efficacy of streptokinase administered intravenously in a two slow and accelerated groups: control group (slow intravenous infusion during 1 hour) and case group (half-hour accelerated intravenous infusion of streptokinase) with the sample size of 100 patients (divided randomly to 50 patients in each group). The data tool was a questionnaire, included the collected ECG changes before and after echocardiography and laboratory tests of patients. Data analyzed with SPSS software using chi-square test. 
Results:After reperfusion of the coronary artery, in the both case and control groups, elevation of ST segment has decreased statistically in two groups (60% and 84%, respectively). The complications rate following injection of SK in both case and control groups were 46% and 56%, respectively. The fraction in which 30% and 38% belong to cardiac complications, 32% and 22% to allergic symptoms and hematologic effects were 32% and 22%, in two groups, respectively and there was no statistically significant difference between two groups. 
Conclusion:According to the results of this study the accelerated (30 minutes) SK infusion can be fruitful for improving coronary reperfusion in patients with MI.
Keywords: Myocardial Infarction, Intravenous Streptokinase, Injection Speed
Full-Text [PDF 130 kb]   (1714 Downloads)    
Type of Study: article |
Received: 2014/06/1 | Accepted: 2015/03/1 | Published: 2015/07/1
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Zamani B, Azari M, Hosseinian A, ShokrDargahy A, Mardi A, Azari S. Effect of the Injection Speed of Streptokinase in Patients with Acute MI Admitted to the Cardiac Intensive Care Section of Imam Khomeiny Hospital in Ardabil 2011-2012. J Ardabil Univ Med Sci. 2015; 15 (2) :128-136
URL: http://jarums.arums.ac.ir/article-1-845-en.html


Volume 15, Issue 2 (summer 2015) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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