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:: Volume 12, Issue 4 (winter 2012) ::
J Ardabil Univ Med Sci 2012, 12(4): 373-383 Back to browse issues page
Effects of ω-3 Fatty Acid Supplementation on Glycemic Status and Hhigh Sensitive C-Reactive Protein in Women with Polycystic Ovary Syndrome
Maryam Rafraf, Elaheh Mohammadi , Laya Farzadi, Mohammad Asghari-Jafarabadi, Siyamak Sabour
Abstract:   (5628 Views)

  Background & Objectives: Polycystic ovary syndrome (PCOS) is one of the major endocrine disorders among females. PCOS is associated with development of type 2 diabetes and cardiovascular disease. The objectives of this study were to determine the effects of omega-3 fatty acids on glycemic status and high sensitive C-reactive protein in women with PCOS.

  Methods: This double-blind randomized controlled clinical trial was conducted on 61 PCOS patients. Subjects in ω-3 fatty acids (n=30) and placebo (n=31) groups take 4 ω-3 fatty acids capsules (each one contained 180 mg eicosapentaenoic acid and 120 mg docosahexanoic acid) or placebo daily for 8 weeks. Anthropometric and biochemical measurments and food intakes were assessed at the beginning and at the end of the study.

  Results: ω-3 fatty acid supplementation caused significant decrease in serum levels of glucose, insulin (p < 0.001 for both) and insulin resistance (p = 0.002) at the end of the study in comparision with baseline values. This was also statistically significant compared to the placebo group (p < 0.001, p = 0.002 and p = 0.001, respectively). No statistically significant differences in serum levels of high sensitive C-reactive protein were obsereved in any of groups at the end of the study (p > 0.05).

  Conclusion: ω-3 fatty acid supplementation had some beneficial effects on glycemic status of PCOS patients and may be useful in prevention and control of metabolic conmplication of this syndrome.

Keywords: Polycystic Ovary Syndrome; ω-3 Fatty Acids; Glycemic Status; High Sensitive C-Reactive Protein
Full-Text [PDF 360 kb]   (1248 Downloads)    
Type of Study: article | Subject: Special
Received: 2012/03/2 | Accepted: 2012/05/20 | Published: 2012/12/21
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Rafraf M, Mohammadi E, Farzadi L, Asghari-Jafarabadi M, Sabour S. Effects of ω-3 Fatty Acid Supplementation on Glycemic Status and Hhigh Sensitive C-Reactive Protein in Women with Polycystic Ovary Syndrome. J Ardabil Univ Med Sci. 2012; 12 (4) :373-383
URL: http://jarums.arums.ac.ir/article-1-73-en.html


Volume 12, Issue 4 (winter 2012) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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