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:: Volume 5, Issue 2 (Summer 2005) ::
J Ardabil Univ Med Sci 2005, 5(2): 142-145 Back to browse issues page
The Effect of Order of Injection of Propofol and Remifentanil on Hemodynamic Changes during Induction of Anesthesia
Jafari Rahimi Panahi , Ata Mahmoudpour, Sohrab Negargar, Rasool Azarfarin
Abstract:   (5201 Views)

 Background & Objectives: One of the most common ways in intubation without muscle relaxant is using propofol and remifentanil. The common practice is injection of remifentanil and then propofol. This occasionally produces severe hemodynamic changes. The aim of this study is to inject propofol followed by remifentanil for evaluating the effect of the order of injection on decreasing these complications.

 Methods: 40 patients with American Society of Anesthesia (ASA) class I-II, who underwent minor elective surgery with airway mallampati class I-II entered the study. Patients were randomized into 2 groups each with 20 patients. The first group received 2.5mg/kg propofol followed by 1.5 g/mg remifentanil while the second group received 1.5 g/mg remifentanil followed by 2.5 mg/kg propofol. Laryngoscopy and hemodynamic changes were compared in two groups.

 Resutls: There was no difference between two groups in laryngoscopy attempts (P=0.145) but the frequency of easy laryngoscopy in the first group (85%) was more than the second group (60%) (P=0.031). Systolic blood pressure changes after laryngoscopy in the first group (20 7.7 mmHg) was less than the second group (28 6.7 mmHg) (P=0.001). There was no statistical significant difference between two groups in diastolic blood pressure and heart rate changes (P=0.88, P=0.86 respectively).

 Conclusion: Administrations of propofol before remifentanil during anesthesia induction produces acceptable hemodynamic changes in patients.

Keywords: Propofol, Remifentanil, Induction, Tracheal Intubation
Full-Text [PDF 218 kb]   (1085 Downloads)    
Type of Study: article | Subject: Special
Received: 2005/01/25 | Accepted: 2005/07/30 | Published: 2005/11/13
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Rahimi Panahi J, Mahmoudpour A, Negargar S, Azarfarin R. The Effect of Order of Injection of Propofol and Remifentanil on Hemodynamic Changes during Induction of Anesthesia . J Ardabil Univ Med Sci. 2005; 5 (2) :142-145
URL: http://jarums.arums.ac.ir/article-1-600-en.html


Volume 5, Issue 2 (Summer 2005) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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