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:: Volume 7, Issue 3 (Autumn 2007) ::
J Ardabil Univ Med Sci 2007, 7(3): 296-301 Back to browse issues page
The Study of the Relationship between Renin-Angiotensin System Polymorphisms and Panel-Reactive Antibodies in Renal Transplant Candidates
Masoud Noroozianavval , Peghah Veisi, Mohammad Aghaeishahsavari, Hasan Argani, Nadere Rashtchizadeh, Amir Ghorbanihaghjo
Abstract:   (4945 Views)

  Background & Objectives : Panel-reactive antibody (PRA) is a routine test to evaluate for sensitized human leukocyte antigens (HLA) before kidney transplantation. The present study evaluates the correlation of renin-angiotensin system (RAS) polymorphisms with the level of PRA in renal transplant candidates.

  Methods: This study included 108 renal transplant candidates. The current patients sera were screened by standard complement-dependent microlymphocytotoxicity technique. RAS polymorphisms were determined by polymerase chain reaction. PRA<10, 10-29, 30-49, and ≥50 considered as negative, mild, moderate, and highly positive PRA, respectively.

  Results: Twelve (11.1%) patients had positive PRA, among them 10 (83.3%) had mild and 2 (16.7%) of them had moderate PRA levels we had no highly positive PRA. Ninety-six of cases (88.9%) were negative for PRA. There was no significant correlation between discrete RAS polymorphisms (alone or together) and the degree of panel antibody reactivity (P>0.05).

 Conclusion: We suggest that none of the RAS polymorphisms could predict the positivity degree of PRA level.

Keywords: PRA, RAS polymorphism, PCR, Renal Transplant
Full-Text [PDF 116 kb]   (1429 Downloads)    
Type of Study: article | Subject: Special
Received: 2006/08/29 | Accepted: 2006/12/18 | Published: 2008/04/14
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Noroozianavval M, Veisi P, Aghaeishahsavari M, Argani H, Rashtchizadeh N, Ghorbanihaghjo A. The Study of the Relationship between Renin-Angiotensin System Polymorphisms and Panel-Reactive Antibodies in Renal Transplant Candidates. J Ardabil Univ Med Sci. 2007; 7 (3) :296-301
URL: http://jarums.arums.ac.ir/article-1-379-en.html


Volume 7, Issue 3 (Autumn 2007) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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