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:: Volume 8, Issue 2 (Summer 2008) ::
J Ardabil Univ Med Sci 2008, 8(2): 117-126 Back to browse issues page
Effect of Losartan and Enalapril on Acute Phase Reeactant (CPR) and Total Anti-oxidant in Renal Transplant Recipients with Renin-Angiotensin system polymorphisms
Mohammad Aghaeishahsavari , Masoud Noroozianavval, Peghah Veisi, Hasan Argani, Nadereh Rashtchizadeh, Amir Ghorbanihaghjo, Sima Abedi-Azar, Amirmansoor Vatankah
Abstract:   (5432 Views)

 Background & Objective: As renin-angiotensin system (RAS) activity could affect the severity of oxidative stress and inflammatory markers the effect of enalapril and losartan on these markers in renal transplant recipients (RTRs) with RAS polymorphisms was assessed.

 Methods: After determination of RAS genotypes including angiotensin converting enzyme (ACE I/D), Angiotensinogen (AGT M235T) and angiotensin II type 1 receptor (ATR1 A1166C) by PCR, seventy-six RTRs recruited to four groups randomly: first group (17 patients) and second group (24 patients) were treated with E (E+: 10mg/daily) and L (L+: 50 mg/daily) alone, respectively. The third group (17 patients as positive control) received E+L (E+L+: 10mg/daily + 50 mg/daily) and the 4th group (18 patients as negative control) received no medication (E-L-). Hs-CRP and total anti-oxidant (TA) as inflammatory and anti-oxidative markers were measured after 2 months. After 2 weeks as washout period, E group changed to L and vice versa as a cross-over design. They were followed for another 8 weeks and hs-CRP and TA were retested.

 Results: Following up the patients (after 2, 4 months of treatment) in treated groups revealed that hs-CRP and TA levels were significantly decreased and increased (consequently) in E+L+, L+, E+ groups (P<0.05). On analyzing the relationship between RAS polymorphisms with baseline hs-CRP and TA levels, CC genotype of ATR1 had lower hs-CRP levels (P=0.04). But none of the RAS polymorphisms could predict the anti-oxidative and anti-inflammatory response rate to the drugs (P>0.05).

 Conclusion: E and/or L reduce hs-CRP and increase TA regardless of the RAS genotypes.

Keywords: Enalapril, losartan, RAS polymorphisms, Acute Phase Reactant (CPR), Total anti oxidant, renal transplantation
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Type of Study: article | Subject: Special
Received: 2007/05/17 | Accepted: 2008/07/15 | Published: 2009/02/9
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Aghaeishahsavari M, Noroozianavval M, Veisi P, Argani H, Rashtchizadeh N, Ghorbanihaghjo A, et al . Effect of Losartan and Enalapril on Acute Phase Reeactant (CPR) and Total Anti-oxidant in Renal Transplant Recipients with Renin-Angiotensin system polymorphisms. J Ardabil Univ Med Sci. 2008; 8 (2) :117-126
URL: http://jarums.arums.ac.ir/article-1-323-en.html


Volume 8, Issue 2 (Summer 2008) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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